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Pfizer and Moderna vaccines may produce lasting immunity

nature.com

181–190 of 364 posts

Re: Pfizer and Moderna vaccines may produce lasting immunity

#181
post #99

So will natural infection. Resistance to SARS-CoV1 has lasted more than a decade. Coronaviruses mutates far less dramatically than influenza does.

SARS-CoV1 didn't have a pool of 8 billion people to mutate in. It'll get less deadly as time goes by giving fuel to the 'it's just a flu' crowd, killing millions in the meantime and potentially mutating beyond the scope of currently attained immunity, god forbid.

Re: Pfizer and Moderna vaccines may produce lasting immunity

#182
post #83
post #4

This is great news, adding to a report in Nature that the natural immunity produced in people who have already had covid may last a lifetime.[1] In case you hadn't heard, the Cleveland Clinic--consistently regarded as one of the top hospital systems in the United States and in the world--recently shared a study of 52,238 patients showing zero incremental benefit from the jab to the previously infected, recommending t…

>a study of 52,238 patients showing zero incremental benefit from the jab to the previously infected This study ended May 15, 2021, and it notes that: >Lastly, it is necessary to emphasize that these findings are based on the prevailing assortment of virus variants in the community during the study. It is not known how well these results will hold if or when some of the newer variants of concern become prominent. Ano…

Higher antibody levels don't necessarily mean a lower risk of disease. While that's possible it remains unproven. There's more to the immune system than just circulating antibodies.

Re: Pfizer and Moderna vaccines may produce lasting immunity

#183
post #179
post #161

Earlier quoted context omitted.

"for people already seropositive for SARS-CoV-2 antibodies from a previous infection, getting the first dose of an mRNA vaccine increased antibody titers by two orders of magnitude on average" That's not what this says -- you're extrapolating that the vaccine somehow changed the immune response, when this letter is only providing data that people who already had Covid had a clear, ~immediate antibody response to vacc…

>That's not what this says I admit I'm not medically trained, but the graph [1] seems pretty clear to me, and the authors said: > In contrast, participants with SARS-CoV-2 antibodies at baseline before the first vaccine injection rapidly developed uniform, high antibody titers within days after vaccination (median AUC before vaccination, 90 [43 participants]; >at 0 to 4 days, 133 [7 participants]; >at 5 to 8 days, 14…

The graph is quite clear. It shows that seropositive (previously infected) people had a higher pre-existing antibody level before vaccination, and it rapidly increased at days 5-8 post-vaccination -- faster and stronger than in unexposed people. It takes 28+ days and a second dose for the unexposed group to approach the titers seen in the group who already had Covid, and they still don't quite get there.

Most notably, even those previously infected people with ~0 titers at baseline rapidly developed high levels of antibodies at 5-8 days after vaccination. It's a small group, but the rapid nature of the response is telling.

This data is clear that the infected people had a rapid, robust immune response to vaccination. It cannot tell you what you're trying to infer -- that the vaccination itself increased the immune response. To determine that, you'd need to do some other experiment.

Re: Pfizer and Moderna vaccines may produce lasting immunity

#184
post #48

Earlier quoted context omitted.

The best solution for my own self and family is to be part of a system where we all agree to take basic precautions to safeguard the more vulnerable who cannot. If everyone who can get vaccinated does, then it fundamentally changes how dangerous the world is for those who are immunocompromised, or are too young to receive the vaccine. I wish that the number of people too selfish or foolish to receive the vaccine was…

It is not anti-vaccination or anti-medicine to say that it's not someone's business to verify anything. People can go about their own business in the form of a vaccination, a mask, staying at home, or all three until the pandemic is over. It's not someone else's business. That's just how it is in the States, sorry but not sorry. You know that Florida has been back to normal for a long time and covid cases have been c…

If Florida was its own country they would all be dead by now. Given that we know they falsified their numbers how can we draw any conclusions from them?

Re: Pfizer and Moderna vaccines may produce lasting immunity

#185

Earlier quoted context omitted.

Masks do not provide as much protection for the users as for other people. I have a right to use public spaces.

> I have a right to use public spaces. So do I, but you say I shouldn't because you're afraid.

Actually they could be safe from you if you were to vaccinate or wear a mask if you will not do so.

Re: Pfizer and Moderna vaccines may produce lasting immunity

#186

Earlier quoted context omitted.

Could someone elaborate why this particular comment is being downvoted? Or I guess in other words, is there something unique about the mRNA vaccines that make it unnecessary to require "booster shots" (if "booster shots" equate to yearly shots we are used to with the flu variants)? (I legitimately don't know and I am curious. I see the article does reference protection against a variant during a study, but it's uncle…

There's no basis to believe at this point that we'll need "booster shots" of any kind with COVID vaccination, and in fact the opposite seems to be the case, so this comment is being downvoted for spreading misinformation (amusingly, this specific comment will probably be disliked by both vaccination proponents and disease proponents :) The reason we won't need yearly vaccinations as with the flu shots isn't a propert…

How do I reconcile this with the existence of, say, Moderna booster? https://investors.modernatx.com/news-releases/news-release-d...

(Genuine question.)

Re: Pfizer and Moderna vaccines may produce lasting immunity

#187
post #176

Earlier quoted context omitted.

There are repeated calls demanding people with antibodies should be required to get a vaccine shot. However most available science points towards natural immunity having slightly better protection. Is there any science whatsoever showing that antibodies + 1 more shot is better than 2 vaccine shots + 1 additional shot? If antibodies are still more protected than 2 shots, how do we know which option provides the most m…

I misinterpreted your post as some kind of “herd immunity” scheme where we all get infected and that is somehow better. That doesn’t seem to be the argument you were making so I am sorry. It seems like we should be optimizing for vaccinating as much of the (non-antibody) population up to a level where the spread of the virus is contained rather than maximizing resistance in the population with antibodies. There must…

It sounds like we're in agreement. Focusing on requirements for confirmed positive covid patients is of negligible benefit. Once the "people without antibodies" actual risk factor is curbed, then we hopefully have had the scientific research to determine what the next best lowest hanging fruit to address is.

> I’m not sure it matters if the antibodies are from the vaccine or infection.

I'm not entirely sure either. There is some research that since the vaccine is just the spike protein, while natural immune response was to the entire virus, that the natural immune response is more comprehensive.

Re: Pfizer and Moderna vaccines may produce lasting immunity

#188

Earlier quoted context omitted.

> we will not in the USA tolerate the idea of keeping "certain spaces for the vaccinated only" unless you're referring to hospitals only This is a regional thing. Most large events in New York have been mandating and verifying vaccination. Most major offices are tracking vaccination status--you're not barred, but you need to wear a mask if you aren't. (Though some are refusing the unvaccinated.) In dense, urban envir…

Large events outside of New York have not had any such vaccine mandates, and have not led to any outbreaks. By the numbers, New York has handled the pandemic worse than any state in the US. I'm not sure we should be holding up any of the measures they've taken or are currently taking as any sort of holy grail.

There is a clear cultural schism on this.

When in Arizona, I went to a rodeo that wouldn’t dare check vaccination after a museum fundraiser that required it but didn’t verify. As someone who would like to go to both types of events, a single document would be helpful. If others prefer to constrain themselves, that’s fine. We are discussing privileges, not rights.

Re: Pfizer and Moderna vaccines may produce lasting immunity

#189

Earlier quoted context omitted.

It’s hard to reliably verify previous infection and very safe and easy to get vaccinated, so what’s the point? I’m going to check your profile — 90% chance you spread antivax propaganda. Edit: yup. Every time.

Good antibody tests are extremely (99%) accurate in verifying previous infection, not sure why you're claiming the opposite...? And while vaccination is safe and easy to get , both me and a lot of my friends were basically as sick as a regular flu for a day or two from it. Some people have no reaction, which is wonderful, but a lot of people need to take a sick day or two, or intentionally get the vaccine on a Friday…

How long after infection will an antibody test work? I have had 2 instances of suspected Covid infection, one where my friend who I had met outside for a walk actually tested positive. The latest was probably November 2020. Would I still be able to identify infection with the antibody test?

Re: Pfizer and Moderna vaccines may produce lasting immunity

#190

Earlier quoted context omitted.

As a Canadian who emigrated to the US, the attitude you so proudly display--ostracizing people who aren't convinced of a novel vaccine with zero long-term safety information--makes me so happy I live here.

How sure are you about the long term effects of COVID?

Oh, not very sure at all. However, I may have already have it, so that cat's out of the bag (and invalidates any reason to get the vaccine anyways). Or I may never get it. Taking the vaccine, which includes three brand new medical technologies and has not completed phase3 trial, guarantees me taking that risk.

I am extremely healthy, have a great diet, and as a farmer, I get plenty of time soaking up vitamin D, a potent inhibitor of covid. The vaccine doesn't make any sense for me to take.

Normal disclaimer, I am a huge, huge believer in vaccines, and am probably more vaccinated (due to travel and other circumstances) than nearly everyone reading this comment. I believe bar none vaccines are the medical technology that has saved the most lives in our history as a species. Big fan of vaccines.

But, vaccines are made safe via clinical trials and long-term studies. These vaccines are wholly new in type, were rushed to market, have liability waivers for those pushing them, and to make things even worse, the manufacturers aren't collecting followup data about adverse events in any kind of systematic way (as they would during a normal phase4). So it seems to me the playbook that gave us generations of safe vaccines that saved billions of lives has been thrown out the window.

No thanks!

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