Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Ibuprofen alters human testicular physiology

pnas.org

Post reply on HN
Print view View original

181–190 of 216 posts

Re: Ibuprofen alters human testicular physiology

#181

Post by swsieber »

adventured wrote: post #158
nikolay wrote: post #115

Earlier quoted context omitted.

In Europe, there's Aspirin-C and Upsarin, basically, pure aspirin with vitamin C, which eliminates the stomach lining issues [0]! I have no idea why this is not offered in America. Maybe, because there's no way to make money from patents and stuff! [0]: https://www.huffingtonpost.com/leo-galland-md/aspirin-and-vi...

> Maybe, because there's no way to make money from patents and stuff That's definitely not the reason. The over the counter pain killer / pain management sections in CVS, Walgreens and Walmart are half filled with generic options.

No, it could be the reason. The patent/money issue is related to the initial FDA approval, which is very expensive (clinical trials).

If no one foots the bill for the testing, it won't spawn a FDA approved thing, right? And if it's not patentable, then it's not worth the effort to go through those hoops, because you won't be able to recoup the costs of doing the FDA approval steps because others could also bring generic versions to market right away, without a cool-down period, and at the same price.

If it is patentable, then it's worth it to make the drug and get it approved. You'll have 20 years to recoup the costs before generics can appear.

Re: Ibuprofen alters human testicular physiology

#182

Post by DanieI »

pkaye wrote: post #118
ardit33 wrote: post #23

If you hang around bodybuilding forums you will hear to avoid Ibuprofens as they hurt your ‘gains’ Perhaps bro-science was right in this case

What I've read is that NSAIDs in reducing inflamantion, it can slow down the mobilization of immune cells that help clean up damaged tissues and promote new tissues.

NSAID pain relievers don't have any anti-inflammatory properties when they are taken in over-the-counter dosages.

Re: Ibuprofen alters human testicular physiology

#183

Post by igor47 »

bluedevil2k wrote: post #103
ardit33 wrote: post #23

If you hang around bodybuilding forums you will hear to avoid Ibuprofens as they hurt your ‘gains’ Perhaps bro-science was right in this case

Bodybuilders tend to not rely on their testes for testosterone production though

No post body was provided.

Re: Ibuprofen alters human testicular physiology

#185

Post by inertial »

fencepost wrote: post #13

Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?

For Dengue fever, aspirin can be fatal:

"infecting organism in dengue affects the platelets which are responsible for clotting (stopping bleeding) increasing the tendency of the person to bleed. Aspirin and Ibuprofen also have similar action. Both of them together could cause the person to bleed excessively pushing the patient into what is called the ‘Dengue Shock syndrome’. And once in this stage, medical treatment is needed in an emergency basis and hospitalization becomes necessary"

http://www.thehealthsite.com/diseases-conditions/dengue-feve...

Re: Ibuprofen alters human testicular physiology

#187

Post by carlmr »

kbart wrote: post #184
Alex3917 wrote: post #15

At 1200mg/d, I feel like destroying your reproductive system would be the least of your concerns.

I take a single 400mg pill whenever my head hurts, so I can imagine that 1200mg/day for a more serious issue is not that uncommon.

I used 2400mg/d for a week after getting my wisdom teeth out. It wasn't enough, but it was the maximum dosage according to the package.

Re: Ibuprofen alters human testicular physiology

#188

Post by carlmr »

seibelj wrote: post #36

As much as possible, I believe we should all try to do everything in moderation. Never be too extreme in medicine, exercise, drinking, drugs, food, etc. Sometimes in life you can't avoid the situation, unfortunately.

A friend of mine had some good wisdom from her mom. If you have to take medication, take different ones, not always the same ones. If you eat premade food, buy different kinds, not always the same ones.

It's basically portfolio risk diversification. You increase the risk of having some negative effects, by virtue of trying more things, but you hugely decrease the risk of taking one thing excessively that does you a lot of harm in the future.

Re: Ibuprofen alters human testicular physiology

#189

Post by carlmr »

function_seven wrote: post #165
3pt14159 wrote: post #133

Earlier quoted context omitted.

Yes. Let me rephrase what you phrased: Imagine you're investigating a drug for hair loss, like 20000 other researchers hellbent on achieving their goals. You gather a group of 31 bald white men. 15 of them take a placebo and 16 take the experimental drug for 24 weeks, but because your random allocation put more extra bald people in your non-control group you fixed it by balancing the two groups. Your counterpart that…

You had to introduce a lot of assumptions to invalidate the n=31. So let me lay it out in more detail. I recruited 31 white men who self-report having no hair on at least 500cm^2 of their head. They all had hair as adolescents, and lost it gradually throughout their 20s or early 30s. They're all at least 37 now. I then sort them into the two groups by assigning sequential IDs in random order. Those with an odd ID are…

The point is though, that if enough people do the same study, and only the positive results are published, you're increasing the odds a lot of getting a positive result from someone. That's why companies often finance studies in their drugs. If enough people study their drugs, something which doesn't have a measureable effect, might have a measureable effect in some of these studies. At which sample size this becomes reasonable is a good question though.

Re: Ibuprofen alters human testicular physiology

#190

Post by sreaching »

cookiecaper wrote: post #61
MollyR wrote: post #3

It would be mind boggling if pain killers were connected to dropping male fertility. It might even explain why so many cultures had rites to male adulthood involving extreme pain.

Where can I read about "dropping male fertility" as a medical thing? Just taking a blind guess, as someone who doesn't follow the medical field, I would suggest that increases in "infertility" are much more likely to be caused by the older age at which people are becoming interested in "fertilization" than environmental factors causing biological malfunctions. In other words, it's not that reproductive systems are br…

testosterone levels have declined in most developed countries when comparing similar age cohorts over time. See the following studies: from Finland - https://www.ncbi.nlm.nih.gov/pubmed/23161753. from USA - https://academic.oup.com/jcem/article/92/1/196/2598434

it is a bit of a medical mystery because the trend cannot be fully explained by lifestyle factors like weight gain.

Post reply on HN