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Fecal transplants for autism deliver success in clinical trials (2019)

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Re: Fecal transplants for autism deliver success in clinical trials (2019)

#171
post #147

Earlier quoted context omitted.

Yeah, I see the word "DX'ed" and immediately think of getting clotheslined by Triple H.

Now I'm even more confused. I can read every word in that sentence but I have no idea what it means.

I believe they're talking about wrestling, the WWE type of wrestling with characters and story lines and flashy moves.

Re: Fecal transplants for autism deliver success in clinical trials (2019)

#172

Earlier quoted context omitted.

Study completed in 2022, but still no results posted or study published.

I've never really thought about this but, could it be because they don't want people to "try this at home"? Either because of safety issues, or my actual hypothesis, because they want to keep their possible pool of candidates as big as possible?

No, they have a patent so they would be in a hurry to publish if the results were good.

From the comments in the article above, it sounds like it may have failed it's primary outcome (autism symptoms). They only say there was significant benefit for "average of all symptoms", but it isn't clear if that is the same thing.

Re: Fecal transplants for autism deliver success in clinical trials (2019)

#173
post #70

Many autistic children have extremely limited diets. For example, a geneticist friend of mine saw a case where an autistic child had been referred for genetic testing because of horrific, chronic, spontaneous wounds on gums and skin. Turned out to be scurvy, because he had exclusively eaten Wheat Thins for the last 3-4 years, which aren’t fortified with vitamin C. I would fully expect that a monotonous diet leads to…

Just to play devil’s advocate, isn’t it also possible that the preference for a monotonous diet is driven by gut makeup?

this relies a bit on a healthy brain to make s good correlation. an unhealthy brain might make a bad diet just out of habit/compulsion rather than driven by their biology.

Re: Fecal transplants for autism deliver success in clinical trials (2019)

#174
post #147

Earlier quoted context omitted.

Yeah, I see the word "DX'ed" and immediately think of getting clotheslined by Triple H.

Now I'm even more confused. I can read every word in that sentence but I have no idea what it means.

There is a very popular wrestler who works for WWE who goes by the stage name Triple H. Triple H was part of a group called D Generation X, or DX for short. A clothesline is one of the most basic wrestling moves. This is not sport wrestling, but entertainment wrestling.

Re: Fecal transplants for autism deliver success in clinical trials (2019)

#175
post #148

> Prior to the study, 83% of participants had "severe" autism. Two years later, only 17% were rated as severe, 39% as mild or moderate, and incredibly, 44% were below the cut-off for mild ASD. Pretty incredible if true!

I think the terminology of "incredible" is the operative word but I agree, if it could help, great. But I'm very skeptical. I find it hard to think that your gut biome can affect your brain so much that you struggle with social queues but are able to have an amazing memory. But then I've met people not on "the spectrum" who have an amazing memory, such as a professor I recently met with who could remember the page nu…

You should read up - you're pretty obviously misunderstanding the diagnosis.

Maybe think of this as removing a long-standing distraction or irritant. Like turning down the music from 120 decibels to 80 while you're trying to work.

Re: Fecal transplants for autism deliver success in clinical trials (2019)

#176
post #70

Many autistic children have extremely limited diets. For example, a geneticist friend of mine saw a case where an autistic child had been referred for genetic testing because of horrific, chronic, spontaneous wounds on gums and skin. Turned out to be scurvy, because he had exclusively eaten Wheat Thins for the last 3-4 years, which aren’t fortified with vitamin C. I would fully expect that a monotonous diet leads to…

Just to play devil’s advocate, isn’t it also possible that the preference for a monotonous diet is driven by gut makeup?

[deleted]

Re: Fecal transplants for autism deliver success in clinical trials (2019)

#177
There's a greentext that's been floating around for a while, I don't know the original author and can't remember the exact text to search for it, but it's along the lines of

> my deepest fantasy is that one day I'll be in the hospital for some random thing, they'll take blood for some test, and then when they read the results, their eyes will go wide and they'll call for a consult. The other doctor will read the results and say "you don't have the nutrient?! How do you live? You're so brave". They give me a shot, and just like that, I'm able to conduct myself in society, understand social cues, hold my attention on anything i want for any length of time, etc

... so perhaps the Nutrient is a product of a gut bacterium.

Re: Fecal transplants for autism deliver success in clinical trials (2019)

#179
post #148

Earlier quoted context omitted.

I think the terminology of "incredible" is the operative word but I agree, if it could help, great. But I'm very skeptical. I find it hard to think that your gut biome can affect your brain so much that you struggle with social queues but are able to have an amazing memory. But then I've met people not on "the spectrum" who have an amazing memory, such as a professor I recently met with who could remember the page nu…

You should read up - you're pretty obviously misunderstanding the diagnosis. Maybe think of this as removing a long-standing distraction or irritant. Like turning down the music from 120 decibels to 80 while you're trying to work.

Hmm, that's one explanation, but I'm curious what leads you to believe it's the correct one?

I'm struck by this quote, which I'd be surprised if they could be explained fully by the distraction-reduction mentioned:

> "Evaluation of symptoms on the Parent Global Impressions found that the treatment group at the end of part 2 improved more than the placebo group in part 1 on nearly all symptoms, with statistically significant improvements in GI, receptive language, and average of all symptoms. There were also marginally significant improvements in tantrums, stimming/perseveration, and cognition."

Re: Fecal transplants for autism deliver success in clinical trials (2019)

#180
post #70

Many autistic children have extremely limited diets. For example, a geneticist friend of mine saw a case where an autistic child had been referred for genetic testing because of horrific, chronic, spontaneous wounds on gums and skin. Turned out to be scurvy, because he had exclusively eaten Wheat Thins for the last 3-4 years, which aren’t fortified with vitamin C. I would fully expect that a monotonous diet leads to…

Just to play devil’s advocate, isn’t it also possible that the preference for a monotonous diet is driven by gut makeup?

couldn't it just be perpetuated, after the other occurrence too?

just to play devil's advocate that it isn't an opposing possibility

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