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Kenvue stock drops on report RFK Jr will link autism to Tylenol during pregnancy

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Re: Kenvue stock drops on report RFK Jr will link autism to Tylenol during pregnancy

#171

Post by xeromal »

johnisgood wrote: post #167
docstryder wrote: post #75

It is the safest painkiller currently available. Ibuprofen can cause gut bleeding and renal issues if overdosed on. We all know about opiates. Some facts - typical adult dose is 1g. Max suggested cap on the drug label is 3g per day (about 6 pills at usual 500mg dose). You need to take 10g (20 pills) to be at real risk of hepatotoxicity. So 10 times the typical dose is when you have overdose effects. (basically 20 pil…

> We all know about opiates No, I do not think we do, because it causes none of the side-effects associated with NSAIDs, and it is even safer than acetaminophen, i.e. there is no risk of hepatotoxicity whatsoever. The only side-effect is euphoria. Please do not mention respiratory depression here, that is a non-issue, it matters as so much as liver failure matters with acetaminophen overdoses. Opiates are safer than…

They do cause constipation

Re: Kenvue stock drops on report RFK Jr will link autism to Tylenol during pregnancy

#172

Post by tim333 »

swed420 wrote: post #152
tim333 wrote: post #151

Earlier quoted context omitted.

It it was like that it would be a US specific thing but basically every country on earth has mostly stopped worrying about COVID.

Agreed, and guess how many countries prior to COVID followed our CDC's lead? The answer is most of them. The fact remains that people are slowly waking up to this and altering their behavior even into 2025, since it's not always too late to do so. You can see this in the steady growth of the /r/ZeroCovidCommunity subreddit.

That's kind of interesting - I didn't know the ZeroCovidCommunity existed.

Re: Kenvue stock drops on report RFK Jr will link autism to Tylenol during pregnancy

#173

Post by jeffbee »

kosma wrote: post #164

There is research correlating autism and mothers taking certain medications (painkillers, antidepressants). Since autism is hereditary, there is a significant chance that these mothers are autistic too. Autistic people have a vastly high risk of depression, and often have unusual pain thresholds, requiring more painkillers. I would not be surprised of the correlation was real, but the direction of action was reversed…

[flagged]

Re: Kenvue stock drops on report RFK Jr will link autism to Tylenol during pregnancy

#174

Post by johnisgood »

xeromal wrote: post #171
johnisgood wrote: post #167

Earlier quoted context omitted.

> We all know about opiates No, I do not think we do, because it causes none of the side-effects associated with NSAIDs, and it is even safer than acetaminophen, i.e. there is no risk of hepatotoxicity whatsoever. The only side-effect is euphoria. Please do not mention respiratory depression here, that is a non-issue, it matters as so much as liver failure matters with acetaminophen overdoses. Opiates are safer than…

They do cause constipation

You are right. It varies a lot though by different opioids and dosage plays a major role, too.

Morphine causes more constipation than oxycodone does, for example (not to mention IR vs ER formulations), and in some people morphine causes more sedation and oxycodone might be more stimulant-ish, so they may be opioids / opiates, but they can be significantly different.

That said, constipation can indeed be a major issue, especially in the elderly, but they are most likely are already taking or being given laxatives.

For adults without any GI problems, they can safely be on a better diet and take magnesium citrate before they want to defecate (if they have no kidney issues either). It takes 4-12 hours for magnesium citrate to work. There is an even better form of magnesium, but magnesium citrate should be fine, along with prunes or prune jam, lots of hydration and so forth.

I take opiates for pain, and the way I manage constipation (which is indeed frustrating) is through diet (fibre, prune jam, and so forth) and skipping two days (of the ER formulation) if I have no stool for a few days, along with taking magnesium citrate. I would not recommend taking opiates AND laxatives all the time (or rather, I do not recommend treating OIC with regular consumption of laxatives). Constipation would not be a problem with lower doses and IR formulations though, or much less so.

Just FWIW, if you can pass gass, your bowels are not obstructed, and it is a good sign, so if you take opiates, pay attention to that. If you cannot pass gas and you have abdominal pain, then it can easily become a medical emergency. You should not get to this point though, either by taking less, switching to a different formulation (ER -> IR), or switching to a different opioid, along with a better diet.

Additionally, if you do not take opioids (especially ER ones) on a regular basis (similarly to how some people only take NSAIDs once in a while), then constipation is not going to be an issue at all.

I hope this answers your concerns regarding opioid-induced constipation.

Re: Kenvue stock drops on report RFK Jr will link autism to Tylenol during pregnancy

#175

Post by closewith »

_DeadFred_ wrote: post #157
giardini wrote: post #154

Earlier quoted context omitted.

My mom gave me one 325 mg aspirin dissolved in a spoon of water and a little sugar as a tot - it was tasty! I took the typical two 325 mg aspirin for headache thru college and grad school. Years later I had a cracked rib and was prescribed 800 mg ibufprofen twice daily. The rib pain vanished for the duration (and my swim times improved significantly)! I became a convert to Advil. Years later I'm older and minimize my…

Isn't it highly recommended to not give Aspirin to young people because of Reye’s syndrome risks?

Yes, contraindicated for under-16s everywhere I've worked.

Re: Kenvue stock drops on report RFK Jr will link autism to Tylenol during pregnancy

#176

Post by russdill »

protonbob wrote: post #85

There really are risks. It's just not worth it during pregnancy. The pain killing effects of tylenol aren't worth the potential risks during pregnancy. https://www.mountsinai.org/about/newsroom/2025/mount-sinai-s...

There are also real risks to ignoring pain and the destructive effects it has to quality of life and mental well being, all of which can have effects on the mother's and the fetus's health.

What is a pregnant person with debilitating pain such as a migraine supposed to do?

Re: Kenvue stock drops on report RFK Jr will link autism to Tylenol during pregnancy

#177

Post by op00to »

throw0101c wrote: post #103
op00to wrote: post #64

Earlier quoted context omitted.

There’s a marked increase in mental illnesses diagnosed. My parents were heavily depressed and anxious, but in their day it was taboo to seek help and admit such a diagnosis. We are so much more sophisticated today.

> There’s a marked increase in mental illnesses diagnosed. There was a marked increase in left-handedness once the 'stigma' of it was removed.

This sinister finding must be further investigated.

Re: Kenvue stock drops on report RFK Jr will link autism to Tylenol during pregnancy

#178

Post by op00to »

viraptor wrote: post #72
op00to wrote: post #61

Earlier quoted context omitted.

Some times advil works. Some times aspirin works. Some times Tylenol works. Some times none of them work. There’s all kinds of substances that are available freely that can kill you if you take too much. NSAIDS, Imodium, DXM, iron supplements.

Water. https://en.wikipedia.org/wiki/Water_intoxication Meat. https://en.wikipedia.org/wiki/Protein_toxicity

I don’t know about water, but Hydrohydroxic acid is a solvent for ANYTHING! That can’t be good.

Re: Kenvue stock drops on report RFK Jr will link autism to Tylenol during pregnancy

#179

Post by tsoukase »

elric wrote: post #68

Was replying to a commented which was downvoted to death entirely unfairly, so I'll paste my reply as a new comment: Paracetamol/acetaminophen (the active ingredient in tylenol) is super toxic to the liver. Lots of people overdose on it, some by accident and some deliberately. As little as FOUR GRAMS can cause jaundice and fuck up your liver. If you have a fever, taking 1 gram every couple of hours might seem entirel…

Taking so much paracetamol so often will totally lose its effect after 2-3 doses. If you continue, then it's considered suicide attempt zone.
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