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Review of Anti-Aging Drugs

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Re: Review of Anti-Aging Drugs

#171

Post by JPLeRouzic »

nikolay wrote: post #169
JPLeRouzic wrote: post #165

Earlier quoted context omitted.

No worries! Not all cells divide (neurons and some muscle cells don't divide); some cells divide very slowly. And in some cases telomeres may be repaired but this increases the risk of cancer [0] https://biologyinsights.com/what-is-telomere-repair-and-is-i...

I'm fully aware of cancer risks with substances such as astalagus extract, but maybe telomerase activators can be combined with anti-cancer strategies such as fasting, etc.

What I mean is that the Hayflick limit is a concept from the laboratory; it applies to cells that divide quickly, like skin cells, but it has limited practical use for strategies aimed at extending an animal's lifespan, because as the animal or human ages, it will lose neurons and muscle strength (including heart muscle).

In other words, 100% of humans relying only or mainly on telomere repair will be faced with Alzheimer’s, Parkinson’s, and/or ALS, as well as cardiovascular diseases, before they reach 100 years old.

Re: Review of Anti-Aging Drugs

#173

Post by nikolay »

JPLeRouzic wrote: post #171
nikolay wrote: post #169

Earlier quoted context omitted.

I'm fully aware of cancer risks with substances such as astalagus extract, but maybe telomerase activators can be combined with anti-cancer strategies such as fasting, etc.

What I mean is that the Hayflick limit is a concept from the laboratory; it applies to cells that divide quickly, like skin cells, but it has limited practical use for strategies aimed at extending an animal's lifespan, because as the animal or human ages, it will lose neurons and muscle strength (including heart muscle). In other words, 100% of humans relying only or mainly on telomere repair will be faced with Alzh…

I thought we're past the times when we thought cartilage, neurons, and other tissues cannot regenerate. Didn't we, for example, find that BDNF activators can trigger neurogenesis?

Re: Review of Anti-Aging Drugs

#174

Post by JPLeRouzic »

nikolay wrote: post #173
JPLeRouzic wrote: post #171

Earlier quoted context omitted.

What I mean is that the Hayflick limit is a concept from the laboratory; it applies to cells that divide quickly, like skin cells, but it has limited practical use for strategies aimed at extending an animal's lifespan, because as the animal or human ages, it will lose neurons and muscle strength (including heart muscle). In other words, 100% of humans relying only or mainly on telomere repair will be faced with Alzh…

I thought we're past the times when we thought cartilage, neurons, and other tissues cannot regenerate. Didn't we, for example, find that BDNF activators can trigger neurogenesis?

How do you create a well-connected motor neuron with a 3-foot or one-meter-long axon? Or brain neurons that are highly connected to other areas?

I would appreciate any pointers to a scientific article that describes this.

Re: Review of Anti-Aging Drugs

#175

Post by nikolay »

JPLeRouzic wrote: post #174
nikolay wrote: post #173

Earlier quoted context omitted.

I thought we're past the times when we thought cartilage, neurons, and other tissues cannot regenerate. Didn't we, for example, find that BDNF activators can trigger neurogenesis?

How do you create a well-connected motor neuron with a 3-foot or one-meter-long axon? Or brain neurons that are highly connected to other areas? I would appreciate any pointers to a scientific article that describes this.

Peripheral neurons can regenerate [0]. Heart muscle also can repair through other factors [1].

[0]: https://pmc.ncbi.nlm.nih.gov/articles/PMC6336700/

[1]: https://www.sciencealert.com/new-study-reveals-more-about-ho...

Re: Review of Anti-Aging Drugs

#176

Post by DrBenCarson »

djmips wrote: post #122
DrBenCarson wrote: post #56

Earlier quoted context omitted.

Latest research (as in only ~2m old) dispels that narrative a bit but not entirely. Looks like spermidine is the autophagy signal but they’re not sure fasting does t always increase spermidine Also…lifting light weights for like 10 minutes a day at home is a lifechanger in the early days

What do you mean by 'the early days' ? And how is it a life changer?

Early days as in the first ~4 months of the journey (which is lifelong…a formerly obese person will always be highly likely to regain the weight)

It’s a life changer because when you’re at a significant caloric deficit, your body sheds both fat and muscle. When you lose muscle, your metabolic rate drops, also lowering your rate of fat loss

If you lift even a little, your body will hang on to muscle more effectively, making it easier to lose and maintain weight over a longer period

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