Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Sleep apnea pill shows striking success in large clinical trial

science.org

Post reply on HN
Print view View original

171–180 of 226 posts

Re: Sleep apnea pill shows striking success in large clinical trial

#171

Post by VectorLock »

elric wrote: post #151
VectorLock wrote: post #149

Earlier quoted context omitted.

I don't know why you're so insistent that anybody who can't tolerate CPAP its a titration or fitment issue. I've talked to people who have loads of interaction with sleep doctors, mask fitment specialists, trying different CPAP/AutoPAP/BiPAP/auto-titration settings and I'm one of them. I'm glad medical science is pursuing other treatments that can help the 40% who can't tolerate CPAP and maybe help some of those who…

Because it usually is an issue of titration or mask fit. There are some cases of people have complex sleep apnea, or having awfully non-compliant airways that require uncomfortably high pressures. But the vast majority of people can tolerate PAP just fine. There are certainly improvements to be made. And thankfully some of them are being worked on (e.g. VCOM or KPAP). And some people could benefit from bilevel or eve…

>Because it usually is an issue of titration or mask fit.

I think it may be in some cases, but not the majority. Talking to my sleep doctor recently I don't think she thinks so either. She starts everyone out on AutoPAP with 5-20 ramp as the standard now. Either way I think people who can't tolerate CPAP will welcoming having a drug as an option before more extreme measures like the Inspire device and Maxillomandibular advancement.

Re: Sleep apnea pill shows striking success in large clinical trial

#172

Post by frosting1337 »

garyclarke27 wrote: post #130
Llamamoe wrote: post #98

Earlier quoted context omitted.

The problem with CPAP is that 40% of patients don't tolerate it even for the 4h/night defined as treatment compliance, while most of the rest use it less than the full duration of the night, with studies demonstrating that treatment compliance depends on efficacy. And this is for traditional OSA in men - people with Upper Airway Resistance Syndrome(mostly identical mechanism as OSA, less oxygen desaturation, more aro…

I never had a problem with adopting CPAP. It's been transformative for me, sleep quality is literally 10 times better than without, I wake up feeling awful if I have a nap without it. Why would someone keep a mask on for 4 hours, then take it off? does not make sense to me.

It took me a year to get used to my mask, and I use a pillow mask. The difference with and without is night and day, yeah, but man adapting fucking _sucked_.

Re: Sleep apnea pill shows striking success in large clinical trial

#173

Post by subsaharancoder »

BurningFrog wrote: post #93
aziaziazi wrote: post #46

Earlier quoted context omitted.

> letting my partner have a proper night's sleep I’m interested in this: how’s the CPAP noise perceived by the partners? I don’t snore and usually wake up quickly when doing the "apnea noise", stopping before waking her up. In the meantime I read that CPAP produce a a constant sound + an inconstant sound from the air coming in and out. She needs quietness to sleep and disturbing her sleep refrained me to try it out.…

A new Resmed machine is inaudible to my ears. But after 1-2 years, all 3 of mine has developed some kind of noise. I recently found an online service that repaired one of mine, and it's quiet now. There is also mask noise. If my nostril mask slips out a bit, there will be noise. Not too big a deal. One fix that I think would work for most people is a white noise machine. It's briefly annoying, but after a while (a fe…

> A new Resmed machine is inaudible to my ears. But after 1-2 years, all 3 of mine has developed some kind of noise.

This is my experience, I've tried swapping out tubes, the water container, but the noise is just unbearable and I can't even fall asleep while wearing it.

Re: Sleep apnea pill shows striking success in large clinical trial

#174

Post by tayo42 »

kimjune01 wrote: post #91

Sleep apnea is a structural issue, either soft or bone. CPAP helps, but it doesn't address the root cause. Fixing it is a matter of airway geometry, with many obstructions along the way. Bodybuilders or wrestlers, otherwise in good health, can suffer from OSA because of too much muscle in their neck. You may not know it, but your tongue may be tied. It is one of many possibilities causing OSA. I made this: Do I have…

What do you former wrestlers do?

Idk how to target loss in just my neck.

Im pretty sure my neck from teenage wrestling and my adult hobby of bjj is messing me up a little .

Also annoying for getting fitted shirts lol

Re: Sleep apnea pill shows striking success in large clinical trial

#175

Post by BurningFrog »

subsaharancoder wrote: post #173
BurningFrog wrote: post #93

Earlier quoted context omitted.

A new Resmed machine is inaudible to my ears. But after 1-2 years, all 3 of mine has developed some kind of noise. I recently found an online service that repaired one of mine, and it's quiet now. There is also mask noise. If my nostril mask slips out a bit, there will be noise. Not too big a deal. One fix that I think would work for most people is a white noise machine. It's briefly annoying, but after a while (a fe…

> A new Resmed machine is inaudible to my ears. But after 1-2 years, all 3 of mine has developed some kind of noise. This is my experience, I've tried swapping out tubes, the water container, but the noise is just unbearable and I can't even fall asleep while wearing it.

This place silenced and returned mine within a week: https://cpap-repair.com/

Re: Sleep apnea pill shows striking success in large clinical trial

#176

Post by mrlatinos »

johntash wrote: post #161
ProllyInfamous wrote: post #125

I am a fattie (BMI 36.5). I also have sleep apnea. Wearing a CPAP, I couldn't ever get any sleep (toss&turner). Things that've helped: 1) Using body pillows to force sleeping on side, which straightens the neck (versus face-down) — also lessens low-back pain 2) DENTAL GUARD (a 3D-printed plastic insert which form-fits my teeth, slightly opening jaw-angle/mouth) 3) Losing weight — YES, sleep apnea is worsened by exces…

What kind of dental guard did you get? One from an actual dentist, or one of those pre-made ones off of amazon/etc? I've been wanting to try one from the dentist, but they're pretty pricey.

Not OP but we sound very similar. I wear a CPAP as well as a night guard. My dentist ordered me a "Max Occlusal Guard H/S Daytime" - it covers my upper teeth, has a hard outer shell and a softer lining. It's very thin and I can use it during the day (as long as I'm not talking) to prevent bruxism. I've used the cheaper Amazon ones - the ones from your dentist are well worth the cost.

Re: Sleep apnea pill shows striking success in large clinical trial

#177

Post by mrlatinos »

evanjrowley wrote: post #82

I must be in the minority of CPAP users who would use it even if I stopped having OSA. Why? A few reasons: 1. Sometimes I hardly notice it. Newer models are very quiet and portable. I'd even go as far as saying the mask is comfortable to wear, like a security blanket for the face. 2. Practically nothing filters out dust and cat hair better than my CPAP. An N95 mask might do better, but would be ridiculously uncomfort…

It took me a LONG time to adjust to CPAP and now I totally agree on all points. I got hooked when I was sick with a nasal infection because of point #3 (plus it was the only thing that allowed me to breathe).

Re: Sleep apnea pill shows striking success in large clinical trial

#178

Post by rlifer »

elric wrote: post #7

I swear CPAP wouldn't get such a bad rep if the media would stop using pictures of men with obscenely large full face masks. The most commonly used CPAP mask is probably the minimalist Resmed P10 [1]. It looks a lot less intimidating than a bulky full face mask. And in most cases, full face masks aren't needed (no sources to cite, but titrating to the correct pressure allows most people to breathe through their noses…

The issue with nose pillow with Resmed or other CPAP is that I often rip them off from my face while sleeping, so I get to use CPAP only a couple of hours or even less. It may have to do with my stuffy nose, but that one is even harder to cure (yes, I use saline solutions to wash my nose, but it helps only so much).

Re: Sleep apnea pill shows striking success in large clinical trial

#179

Post by petesergeant »

cmrdporcupine wrote: post #124
petesergeant wrote: post #116

Earlier quoted context omitted.

A similar fix for me was a nasal steroid taken every night. Got me off the CPAP

Any long term side-effects from that?

Not that I could find, and the doctors seemed pretty happy with it (and it was one who suggested I try it). I'm taking Fluticasone Propionate.

Re: Sleep apnea pill shows striking success in large clinical trial

#180

Post by lzy »

This looks promising, especially for folks who can't tolerate CPAP. Wonder how it performs long-term and if it messes with REM cycles. Also curious about cost and insurance coverage—sleep treatments tend to get expensie fast. Hope follow-up studies confirm these results without major side effects.
Post reply on HN