Live data from Hacker News

Ask HN: A friend has brain cancer: any bio hacks that worked?

news.ycombinator.com

171–180 of 380 posts

Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#171
post #110

You should ask them if they want you playing doctor. I have a chronic disease, not fatal, and totally manageable. But the most annoying thing is when someone finds out and suddenly pretends to be the expert. Of course my doctors and I investigating it for years were completely wrong! I should’ve ate more apricots! Please just check with them if they want their limited time spent like that.

dont get why that upsets you. I have had a chronic disease my whole life and one of the people who offered help completely saved my life. If anyone else told me to eat apricots Id be grateful for their time and attention. I would probably eat the apricots and tell them it was fantastic, even if it had no effect. Sorry I just have rarely seen my friends or family offer any advice. - Back to OP, Ive always remembered P…

>dont get why that upsets you.

Because this often sounds like people think you haven't tried (almost) everything yet and of course they might have a solution.

I think your and parent commenter's situation and reaction are polar though. One was in the situation where they receive an unwelcome advice all too often, the other one would like more attention but never got one.

Notice than you are prepared to do something you are not really iterested in and possibly don't even need - only to give some 3rd party a satisfaction as a "thank you" for their attention.

Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#172
post #2

I have heard some people having luck by switching to a ketogenic diet. Here’s a paper I could find on PubMed about this. Sorry to hear about your friend. https://pmc.ncbi.nlm.nih.gov/articles/PMC9504425/ Edit: I am not a doctor. My wife is a physician and I spoke to her before posting this.

I wish I had something better to add, but I can add an anecdotal +1 to this. A relative went keto pretty hard after a bad diagnosis and they are still going strong. As far as I understand it, cancer cells can only function on glucose.

Some types of cancer cells

Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#173

Here’s a summary of all of the current treatments and near future treatments for GBM/glioma: https://docs.google.com/file/d/1kTa3eamaL91Smjh9r_0CYv5OYFX4... . This is as complete a list as you’ll find, written in plain English, with citations for every part of it. Slightly out of date but there hasn’t been much that’s new and different since last year. Vorasidenib was approved recently in USA and it’s the most effect…

Thanks a lot

Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#175
post #127

Earlier quoted context omitted.

To give a practical example, grapefruit juice contains some compounds that inhibit CYP3A4, a metabolic enzyme that influences the metabolism and absorption of many drugs, which is why many prescriptions tell you not to drink it while taking a given medication. This interaction was not discovered until 1989, and not reported until two years after that. So before 1991, a simple dietary intervention that affected like h…

The problem is you can't figure out where to pick it; it's lost in a sea of superstitious noise. Even if you could find this fruit easily, "a food that cures cancer when eaten" does not exist. That would surface in epidemiological studies very quickly.

I think there is a lot of efficacy left on the table with modern studies, clinical trials, and drug development. Most of the work is looking for treatments that work for the majority of the population. If a treatment was effective than standard care for 10% of people, it would be discarded.

It is more economical to start over looking for something that works for 90% of people.

Drugs an treatments aren't evaluated and discarded when proven worthless. The bottleneck is the number of treatments in development, so they are discarded when something else has a better ROI.

Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#176
post #116
post #87

I know when someone’s faced with certain death they’ll do almost anything they can to survive if only for a little bit longer, but this thread full of personal antectodes and largely non-reproduced effects from random pubmed articles is the hackernews equivalent of essential oils or smth

It's false hope, swallowed hook line and sinker.

Sure this is the right place for a good word

Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#177

Earlier quoted context omitted.

OP is explicitly asking for hacks and "out there" solutions, I think this is a reasonable place to post anecdata, papers, personal theories, etc. as long as people state their confidence level and link to sources when possible

I disagree. OP is just asking for medical misinformation, and it would be irresponsible to provide it. Self-assessed confidence levels are basically useless because the most confident people are generally the most ignorant. It's causal: ignorance causes people to be confident. The more you know, the more you realize how little you know.

OP is asking for lesser-known possible treatments/trials/diets/whatever for a friend who is probably weeks to months from death. And your contribution is to stop people from helping them because of something about what now?

Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#178
post #87

I know when someone’s faced with certain death they’ll do almost anything they can to survive if only for a little bit longer, but this thread full of personal antectodes and largely non-reproduced effects from random pubmed articles is the hackernews equivalent of essential oils or smth

↑This. Stop. No. Don't go down the false hope path. It's cruel AF and puts off acceptance, wasting time that they can put to better use post acceptance. Maybe let your friend explore what they want to do and you just give support. Celebrate what they celebrate and cry with them when they cry. Find(or better make) them some comfy/cute hats. If you want to research the things about the hospital, the procedures they are…

I guess hope can be false now.

Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#179

Earlier quoted context omitted.

There is no diet that will even intervene with cancer, unless the patient dies. Cancer is the patient's own cell that has mutated to a point beyond apoptosis and adapted to be able to draw nutrients from cells around it. It started from just one cell. It has already evaded dietary fluctuations and adapted. EDIT: the reason I'm a spaz about this is I feel too many people focus on diet as the focus of cancer. While it…

I don't understand unreasonable positions like this. Nobody is saying that people should stop "real" treatments or that diet must be the primary or sole focus for treatment. But given that a change of diet (a) costs nothing, (b) has no downsides, (c) potentially may work it seems strange not to do it.

And yet it is a highly focused topic and cancer rates have not gone down.

Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#180
post #45

Earlier quoted context omitted.

No it's so weird, no connection at all between any of them.

Military? Glioblastoma is correlated to military service in the First Gulf War

Radar microwave radiation?
Post reply on HN