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Brain waves appear to wash out waste during sleep in mice

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Re: Brain waves appear to wash out waste during sleep in mice

#171

Post by zachkatz »

magicalhippo wrote: post #155
robg wrote: post #87

If you have any doubts about sleep quantity and quality, worth reading about the glymphatic nervous system, which is so newly discovered likely you didn’t learn about it in school. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/ In short it explains, mechanistically, why poor sleep affects daily cognition, mental health, and age-related declines. Robust scientific theories explain more of the evidence. The glym…

It makes me sad as my SO struggles a lot with sleep. It's been years since she's had a good nights sleep. Sadly her issues are mostly psychologically rooted due to past trauma, while all the treatments seem to be geared towards "simple" physical issues. She's tried contacting various sleep clinics here and they've all said they can't help. She struggles a lot with falling asleep, she's exceptionally sensitive to soun…

If the problem is psychological trauma, wouldn’t therapy be the obvious solution?

Re: Brain waves appear to wash out waste during sleep in mice

#172

Post by FooBarWidget »

moffkalast wrote: post #124
robg wrote: post #87

If you have any doubts about sleep quantity and quality, worth reading about the glymphatic nervous system, which is so newly discovered likely you didn’t learn about it in school. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/ In short it explains, mechanistically, why poor sleep affects daily cognition, mental health, and age-related declines. Robust scientific theories explain more of the evidence. The glym…

I wonder if eventually once this is more thoroughly researched there could be a way to induce constant cleaning instead of having to do it while unconscious at night? Or at least reduce the hours required. If we could solve this we could just stay awake perpetually and instantly gain a 30% longer lifespan as it were.

Philips has a headband product called DeepSleep. They claim it increases your deep sleep by playing some sort of sound during your sleep that induces more deep sleep. For some odd reason, despite being a Dutch company, the product was only sold in the US. I spent a lot of money having it imported to Netherlands.

Unfortunately I can't tell whether it works. I rely on headphones and earplugs to block out sounds during the night. Sounds such as cars and airplanes outside, or other people in the house going to the toilet, tend to wake me up unless I block out those sounds. And the handband is not compatible with headphones or ear plugs.

I wish there is a better solution.

Re: Brain waves appear to wash out waste during sleep in mice

#173

Post by pdntspa »

thatcat wrote: post #158
magicalhippo wrote: post #155

Earlier quoted context omitted.

It makes me sad as my SO struggles a lot with sleep. It's been years since she's had a good nights sleep. Sadly her issues are mostly psychologically rooted due to past trauma, while all the treatments seem to be geared towards "simple" physical issues. She's tried contacting various sleep clinics here and they've all said they can't help. She struggles a lot with falling asleep, she's exceptionally sensitive to soun…

Has she tried cannabis? It prevents dream memory formation and can help with nightmares

In my experience you need a pretty high tolerance and smoke pretty regularly for it to start preventing dreaming. When I intentionally reduced my tolerance to very low levels I started having dreams again.

Re: Brain waves appear to wash out waste during sleep in mice

#174

Post by MaxfordAndSons »

magicalhippo wrote: post #166
thatcat wrote: post #158

Earlier quoted context omitted.

Has she tried cannabis? It prevents dream memory formation and can help with nightmares

Not yet. It's not legal here yet, though recently it's softening up. But we've talked about it, though mostly to reduce her anxiety. If it can help with nightmares as well, then would indeed be quite interesting.

+1 to this. As a long time cannabis user who is quite skeptical of many of the purported health benefits, this is one I’m not at all skeptical about. It’s actually just the other side of the coin of the degraded short/mid term memory that is a well known downside of habitual cannabis use. But as someone with frequent, vivid nightmares when I’m sober, I can attest that cannabis effectively blocks my ability to remember most dreams - which again is a mixed bag, as I enjoy recalling happy or neutral dream, but when I’m stressed being able to basically opt out of vivid nightmares is a huge boon.

Re: Brain waves appear to wash out waste during sleep in mice

#175

Post by magicalhippo »

zachkatz wrote: post #171
magicalhippo wrote: post #155

Earlier quoted context omitted.

It makes me sad as my SO struggles a lot with sleep. It's been years since she's had a good nights sleep. Sadly her issues are mostly psychologically rooted due to past trauma, while all the treatments seem to be geared towards "simple" physical issues. She's tried contacting various sleep clinics here and they've all said they can't help. She struggles a lot with falling asleep, she's exceptionally sensitive to soun…

If the problem is psychological trauma, wouldn’t therapy be the obvious solution?

The root cause is psychological, but it's manifested itself in physical changes. She's hyper-sensitive to certain sounds for example, which causes her to not be able to fall asleep, or to abruptly wake up. Mostly low frequency sounds, so hard to block.

But yeah, as I mention in a reply to a sibling comment, she's tried therapy for years without much progress, though recently making some progress on that front.

Re: Brain waves appear to wash out waste during sleep in mice

#176

Post by magicalhippo »

canadiantim wrote: post #170
magicalhippo wrote: post #155

Earlier quoted context omitted.

It makes me sad as my SO struggles a lot with sleep. It's been years since she's had a good nights sleep. Sadly her issues are mostly psychologically rooted due to past trauma, while all the treatments seem to be geared towards "simple" physical issues. She's tried contacting various sleep clinics here and they've all said they can't help. She struggles a lot with falling asleep, she's exceptionally sensitive to soun…

She should try ketamine. Sounds like it’s exactly what you say, past trauma, that’s holding her back from a good nights sleep. Ketamine has done wonders for someone I love and I would wholeheartedly recommend it. The person in my life who benefited greatly from it only needed one weekend (2 relatively low to medium dose sessions of ketamine) and she was cured of her ptsd. Also strongly recommend weighted blankets, es…

We've investigated ketamine treatment, which does indeed sound very interesting. However very few clinics here that offer it, though it seems to have improved recently. Definitely will follow up on this.

Re: Brain waves appear to wash out waste during sleep in mice

#177

Post by CooCooCaCha »

magicalhippo wrote: post #155
robg wrote: post #87

If you have any doubts about sleep quantity and quality, worth reading about the glymphatic nervous system, which is so newly discovered likely you didn’t learn about it in school. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/ In short it explains, mechanistically, why poor sleep affects daily cognition, mental health, and age-related declines. Robust scientific theories explain more of the evidence. The glym…

It makes me sad as my SO struggles a lot with sleep. It's been years since she's had a good nights sleep. Sadly her issues are mostly psychologically rooted due to past trauma, while all the treatments seem to be geared towards "simple" physical issues. She's tried contacting various sleep clinics here and they've all said they can't help. She struggles a lot with falling asleep, she's exceptionally sensitive to soun…

How healthy is she in general? Does she eat well? Exercise? Have a consistent night routing? Has she tried melatonin? What about sleep apnea?

If she's sensitive to sound and light, what has she tried to address that? Like blackout curtains?

I find it a bit odd that sleep clinics would turn her away so readily.

I understand the struggle though which is why I asked so many questions, because all of these things have factored into my quest for better sleep. The psychological stuff is hard.

Re: Brain waves appear to wash out waste during sleep in mice

#178

Post by randcraw »

0xFEE1DEAD wrote: post #88
samstave wrote: post #45

Earlier quoted context omitted.

I wonder if this state could be ultrasonically induced to have a "sleep helmet" which can calm and align rhythmic waves? and induce an artificial flush or "power nap" -- Well, thats basically the trope of every Cybernetic design, with the connectors comming out the back of head/spine... Like a continual wash which keeps you in this suspended hyper-aware, but calm, rested and focused mental state. This is why cyborgs…

Have you seen the video on hn a couple of weeks ago about the scientist using ultrasound to halt the progression of Alzheimer’s and to treat addiction? Most fascinating video I’ve seen in a long time. Edit: If you haven’t seen it yet, I highly recommend checking it out https://youtu.be/7BGtVJ3lBdE

IIRC, the goal of that effort is simply to violate the blood brain barrier, which may have therapeutic value only under very tightly managed circumstances since violating it likely will yield at least as many demerits as merits since the BBB is essential to keep the brain free of blood-borne toxins.

Re: Brain waves appear to wash out waste during sleep in mice

#179

Post by canadiantim »

magicalhippo wrote: post #176
canadiantim wrote: post #170

Earlier quoted context omitted.

She should try ketamine. Sounds like it’s exactly what you say, past trauma, that’s holding her back from a good nights sleep. Ketamine has done wonders for someone I love and I would wholeheartedly recommend it. The person in my life who benefited greatly from it only needed one weekend (2 relatively low to medium dose sessions of ketamine) and she was cured of her ptsd. Also strongly recommend weighted blankets, es…

We've investigated ketamine treatment, which does indeed sound very interesting. However very few clinics here that offer it, though it seems to have improved recently. Definitely will follow up on this.

I’m from Canada but still I went to one in Iowa, called Driftless Integrative Psychiatry. I can whole heartedly recommend it, the therapist is an absolute gem of a human being. It’s maybe on the bit more expensive side but it was a one off expense and has been one of the best decisions we’ve ever made.

There’s lots popping up now though. Even in Canada I thought we’d have trouble getting support from our family doctor but she was actually supportive so now if we look to do any more can just get referral from the GP here and do it in toronto.

Definitely do hope you give it a try, might be just what your SO has been looking for. Also seriously don’t discount the weighted blanket!

Re: Brain waves appear to wash out waste during sleep in mice

#180

Post by Nemi »

quesera wrote: post #101
theaussiestew wrote: post #16

That's a really interesting scientific finding. From a personal experience, once I closed my eyes and actually observed this phenomenon. I could observe many spherical waves of light each pulsating, and not only that but I could feel the effect of each wave viscerally. It definitely felt healing. I wasn't sure what this was, was it the vibes of meditators around the world? Maybe this research finding is what I was ob…

Reflexively, that doesn't make sense. I cannot imagine perceiving ionic CSF flow with my eyes. But thinking about it more, maybe there is something to it? I'm wholly unqualified to speculate here, but I know computers and computers are exactly the same as everything in the real world, so let's go! ... - When restful and with my eyes closed, I definitely "see" waves move across my field of vision. My eyes see "black"…

Ok, I have never told anyone this, but I also sometimes wake up and “see” like a waterfall effect over my vision. It only happens very rarely and only for less than a minute after I get woken from a deep sleep. It is not unlike a moving sensation or water moving over my eyes. I realized that it is probably fluid moving over my visual cortex and being interpreted as vision. Seems weird and I have nothing to back it up on, but it has happened multiple times over my lifetime and the sensation is exactly the same every time.
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