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Significant breakthrough in search for Parkinson's biomarker

michaeljfox.org

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Re: Significant breakthrough in search for Parkinson's biomarker

#171

Post by vitus »

giantg2 wrote: post #114
vitus wrote: post #62

Earlier quoted context omitted.

If most of the actual harm is being done by your immune system going into overdrive, then yeah, steroids can help. You'd want to simultaneously treat the infection, of course. "Multiple randomized trials indicate that systemic corticosteroid therapy improves clinical outcomes and reduces mortality in hospitalized patients with COVID-19 who require supplemental oxygen, presumably by mitigating the COVID-19-induced sys…

I can see that in some cases. I doubt that would be beneficial in the case of sepsis, right?

Actually, it's complicated, and there really isn't consensus one way or another.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949415/

"Seventeen meta-analyses of these studies have been performed and have similarly shown conflicting results with some demonstrating a survival advantage (4-6) while other have not (7-10). Consequently, true equipoise exists with regards to the clinical benefit of corticosteroids in patients with severe sepsis and septic shock.

...

In summary, the use of corticosteroids in patients with severe sepsis and septic shock is not associated with improved patient centered outcomes, however this treatment is safe and without an increased risk of complications. Corticosteroids appear to have synergistic biological effects when combined with intravenous vitamin C and thiamine and may be associated with improved patient centered outcomes (21)."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604467/

"In this review article, we reviewed a total of eight different articles being done in last 10 years, relevant to the clinical outcome and effects of corticosteroids. Among those, two demonstrated improved clinical outcomes, two showed both improved clinical outcomes and decreased mortality, three showed increased adverse effects, and the remaining one showed unequivocal results."

Re: Significant breakthrough in search for Parkinson's biomarker

#172

Post by giantg2 »

vitus wrote: post #171
giantg2 wrote: post #114

Earlier quoted context omitted.

I can see that in some cases. I doubt that would be beneficial in the case of sepsis, right?

Actually, it's complicated, and there really isn't consensus one way or another. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949415/ "Seventeen meta-analyses of these studies have been performed and have similarly shown conflicting results with some demonstrating a survival advantage (4-6) while other have not (7-10). Consequently, true equipoise exists with regards to the clinical benefit of corticosteroids in pat…

Interesting

Re: Significant breakthrough in search for Parkinson's biomarker

#173

Post by sph »

nkotov wrote: post #122
sph wrote: post #109

Earlier quoted context omitted.

Can we have a line on the HN guidelines saying "telling people you asked about on ChatGPT doesn't make for interesting discussion. Please refrain from doing so." Especially in this case where you don't even tell what did you find out, only that you did ask ChatGPT. Good for you.

It's the new LMGTFY

But posing as helpful instead of sarcastic, yet equally annoying.

Re: Significant breakthrough in search for Parkinson's biomarker

#174

Post by sph »

m463 wrote: post #168
michelb wrote: post #139

Earlier quoted context omitted.

In The Netherlands we have A LOT of farmers with parkinsons. Most, if not all cases seem to be related to Roundup/Glyphosate.

I wonder how much of this gets "downstream" to people eating the food produced. EDIT: https://www.ewg.org/foodnews/summary.php The 2023 DIRTY DOZEN Of the 46 items included in our analysis, these 12 fruits and vegetables were most contaminated with pesticides: Strawberries Spinach Kale, collard and mustard greens Peaches Pears Nectarines Apples Grapes Bell and hot peppers Cherries Blueberries Green beans

The carnivore doesn't sound so idiotic viewed under that lens. The thing about mammals is that they have liver and kidneys, which are remarkably good at filtering toxins. Certainly much better than a plant.

I wonder if the reason many feel better eating only meat is that they avoid pesticides that wreck havoc on their body. I know I do feel like a million bucks after just 10 days, even though it's extremely boring.

Re: Significant breakthrough in search for Parkinson's biomarker

#175

Post by sph »

Workaccount2 wrote: post #136
sbmsr wrote: post #134

Earlier quoted context omitted.

Would nicotine patches help?

I could do that, but I smoked cigarettes for 7 years and then vaped for 9 years. So I don't know if I could jump back into nicotine but hold off on the smoking/vaping aspect of it.

Funny tangent, I quit vaping on 2 Jan 2020 after the worst flu I have ever had (after a flight abroad.. early COVID?) and while I was finally successful after a decade of quitting, it killed all my motivation and energy.

Then I got diagnosed with ADHD, got stimulant meds which restored the energy and then some, and it was clear I had been self medicating all my life with nicotine and I was completely lost without. If one day I lose access to stimulant meds, you better believe I'm back on the patch and/or the vape.

But in general dude, do not joke about nicotine. You are 3 years clean, it's incredibly hard to quit. If you done it once, it doesn't mean you'll do it twice. Maybe avoiding Parkinson's by vaping is a terrible excuse. You've never known addiction if you believe this time you'll be able to control it.

Re: Significant breakthrough in search for Parkinson's biomarker

#176

Post by adultSwim »

m463 wrote: post #168
michelb wrote: post #139

Earlier quoted context omitted.

In The Netherlands we have A LOT of farmers with parkinsons. Most, if not all cases seem to be related to Roundup/Glyphosate.

I wonder how much of this gets "downstream" to people eating the food produced. EDIT: https://www.ewg.org/foodnews/summary.php The 2023 DIRTY DOZEN Of the 46 items included in our analysis, these 12 fruits and vegetables were most contaminated with pesticides: Strawberries Spinach Kale, collard and mustard greens Peaches Pears Nectarines Apples Grapes Bell and hot peppers Cherries Blueberries Green beans

Personally, I'm much more concerned about the risks to farm workers than risks to the general population.

Re: Significant breakthrough in search for Parkinson's biomarker

#177

Post by theGnuMe »

alixanderwang wrote: post #159
athoun wrote: post #138

For those living in the bay area, you should know that the groundwater in many areas is contaminated with TCE due to computer manufacturing industry which used it as a solvent. Dry cleaners are another common culprit of contamination to the groundwater. These groundwater plumes can extend for quite a large distance from the original site of contamination and seep into the first story of residences and buildings throu…

What can I do if I live near one of the red spots? Do air and water filters help?

Open the windows or move. Your tap water is unaffected, you'd have to be on a well to be impacted. But activated carbon water filters work to remove it.

Re: Significant breakthrough in search for Parkinson's biomarker

#178

Post by tornato7 »

hanniabu wrote: post #125
lambdaba wrote: post #6

I just found out about Thiamine (vitamin B1) megadose therapy for Parkinson's: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762356/ Another study: https://pubmed.ncbi.nlm.nih.gov/26505466/ > Conclusions: Administration of parenteral high-dose thiamine was effective in reversing PD motor and nonmotor symptoms. The clinical improvement was stable over time in all the patients. From our clinical evidence, we hypothesiz…

This further assures my thought that Parkinsons is caused by gut bacteria

Say more about your theory

Re: Significant breakthrough in search for Parkinson's biomarker

#179

Post by georgeg23 »

alexpotato wrote: post #155
athoun wrote: post #138

For those living in the bay area, you should know that the groundwater in many areas is contaminated with TCE due to computer manufacturing industry which used it as a solvent. Dry cleaners are another common culprit of contamination to the groundwater. These groundwater plumes can extend for quite a large distance from the original site of contamination and seep into the first story of residences and buildings throu…

This Twitter thread on the specifics of how dry cleaning retail stores contribute to the problem is an excellent quick overview: https://twitter.com/realEstateTrent/status/14378028033139220...

Seems sensationalist

Re: Significant breakthrough in search for Parkinson's biomarker

#180

Post by wharfjumper »

insanitybit wrote: post #81
nequo wrote: post #75

Earlier quoted context omitted.

Why feed yourself with potential misinformation that you don’t know the true source of and you might never double check?

As opposed to? Unless you're actually going to read individual papers, vet the authors, have the baseline statistical knowledge to understand the results, etc, you're always going to be susceptible to potential misinformation. This HN topic is a good example of the difficulty of verifying information. Who's to say that ChatGPT doesn't provide a better job of filtering it out?

Because ChatGPT assembles letters into words and sentences without attribution and so is untrustworthy.
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