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The most effective malaria vaccine yet discovered

blogs.sciencemag.org

171–180 of 289 posts

Re: The most effective malaria vaccine yet discovered

#171
post #168

Earlier quoted context omitted.

What's more representative is "life years lost", and malaria wins there (we've lost many more years to it).

How do you calculate that in an area of the world with the highest rate of child mortality?

Same as in any other area, assume malaria isn't killing babies and do the math. Your question sounds rhetorical but is too simple to answer, so I'm confused.

Re: The most effective malaria vaccine yet discovered

#173
It strikes me as extremely odd to call this a "discovery". The vaccine was very specifically designed to work in exactly its unique mode to be effective against one species of pathogen. We might equally well talk about SpaceX Starship being "discovered".

To me, it is invented, constructed, engineered, or created. What has been discovered?

Re: The most effective malaria vaccine yet discovered

#174

Earlier quoted context omitted.

And the worst thing is: malaria is easily curable, as malaron is not only preventive, but fully kill the plasmodium in the liver cells. Despite that, we don't provide the drug to them. It would cost a fraction of what we spend on research for a vaccine, but no cigar. Of course, there is the argument that we risk developing resistant bugs. But the truth is, if suddenly all mosquitoes were moved magically to the US, yo…

Not sure why you were downvoted down much but here’s my 2 cents. I first started taking anti-malarial medicine as a child. My entire life I’ve been hearing of resistance to one drug and then another drug, and then another. Also, whenever we took chloroquine or any other drugs on a regular basis, we were well aware that having the medicine in our body would not prevent malaria—-we took it just to help reduce the sever…

Thats a weird argument. "Lets not give the medicine that might help as that might also encourage mutations." --> basically you are saying let's deny it to the many dying today in order to ensure the few (that can afford it) can still use it in the future. A deeply immoral and selfish perspective if spelled out this way.

The only solution then is rapid and large-scale intervention. Massive use of the most effective/least side-effect variety of drug for all at risk populations for 3(?) months, then bring in the alternatives and quickly and widely ensure their use in those areas where resistant strains still spread.

Re: The most effective malaria vaccine yet discovered

#175

Earlier quoted context omitted.

It's bizarrely hard to find good explanations of this! The National Malaria Eradication Program, between 1947 and 1951, cut down on malaria transmission enough that the parasite was driven locally extinct. They drained wetlands where mosquitoes bred, sprayed house interiors and mosquito-heavy areas with DDT on a very large scale, and generally engineered a very specific ecological disaster, depriving the parasite of…

If this were the complete story then just a single person coming back to the USA infected would lead to mass infection... Clearly that hasn't happened.

Only explanation I can think of is that the malaria from elsewhere is different somehow, worse adapted to US conditions.

Re: The most effective malaria vaccine yet discovered

#176
post #132

Earlier quoted context omitted.

Malaria used to be common in the US until the 1950s or so. It was eradicated through extensive mosquito control and engineering efforts. Rich countries can cope; it's the developing world that's thoroughly boned, at least until industrial capabilities catch up.

It used to be common in southern Europe as well and was an absolute scourge in SEA until the 20th century.

Not just Southern Europe. Oliver Cromwell (English ruler in 1600s) died of malaria.

Re: The most effective malaria vaccine yet discovered

#177
post #132

Earlier quoted context omitted.

Malaria used to be common in the US until the 1950s or so. It was eradicated through extensive mosquito control and engineering efforts. Rich countries can cope; it's the developing world that's thoroughly boned, at least until industrial capabilities catch up.

I can't help being annoyed by how the West first exterminated malaria at home, and then , once they were safe, started worrying about the ecological consequences of doing the same in Africa.

During cabin decompression, you put your oxygen mask on first, then help others.

Re: The most effective malaria vaccine yet discovered

#178

It's interesting how everyone in this thread (rightly) views this as a promising development, yet whenever articles are posted discussing longevity research, you see ghastly comments like this: https://news.ycombinator.com/item?id=26211722 Isn't that hypocritical?

I'm one of the people who agrees with both sentiments. I think decreasing child mortality is great and that humanity needs people to eventually die.

Dying in itself is not an issue. Early mortality is an issue. Give everyone the chance to live a full life.

Re: The most effective malaria vaccine yet discovered

#179

Earlier quoted context omitted.

It's bizarrely hard to find good explanations of this! The National Malaria Eradication Program, between 1947 and 1951, cut down on malaria transmission enough that the parasite was driven locally extinct. They drained wetlands where mosquitoes bred, sprayed house interiors and mosquito-heavy areas with DDT on a very large scale, and generally engineered a very specific ecological disaster, depriving the parasite of…

If this were the complete story then just a single person coming back to the USA infected would lead to mass infection... Clearly that hasn't happened.

We do still have mosquito abatement programs too.

I know here in Louisiana the local abatement program has trucks that spray synthetic pyrethroid chemicals (resmethrin, sumithrin and prallethrin) at night and uses an organophosphate (naled) from planes.

And residents are routinely urged to be aware of and eliminate standing water on their property.

We just don't use DDT anymore -- we almost wiped out our state bird with it.

Edit: I have to wonder how much housing changes also mattered. With modern air conditioning and well sealed homes it's fairly rare to have mosquitoes in the home at night.

Re: The most effective malaria vaccine yet discovered

#180
post #145
post #132

Earlier quoted context omitted.

Malaria used to be common in the US until the 1950s or so. It was eradicated through extensive mosquito control and engineering efforts. Rich countries can cope; it's the developing world that's thoroughly boned, at least until industrial capabilities catch up.

> Malaria used to be common in the US until the 1950s or so. I had no idea of that, as I suspect many given the time past if you wasn't around then. Did a little digging and nicely covered here: https://www.cdc.gov/malaria/about/history/index.html Which makes me wonder - what the cost of malaria drugs are and how much would it cost to eradicate it. Equally have the true environmental and ecological aspects of eradica…

Afaik mosquitoes don’t really contribute ecologically. They are just nuisance.
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