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Moderna mRNA sequence released to GitHub [pdf]

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171–180 of 389 posts

Re: Moderna mRNA sequence released to GitHub [pdf]

#171
post #35

Earlier quoted context omitted.

> We aren’t that different from machines, we just need to know more about the CPU and all the co-processors and how the logic gates interact Except it is unfortunately not that simple, because it assumes that distinct components such as CPU, co-processors and even logic gates exist in that context, as is totally reasonable to assume on devices created by humans. Abstracting complex machines into distinct components i…

It is actually sort of strange how compartmentalized the living cell is. I guess there is some type of redundancy that comes from compartmentalization that is evolutionarily beneficial.

There is a theory "endosymbiotic hypothesis" that mitochondria were wholesale absorbed bacteria into our DNA line. Which I think is pretty wild, and explains how neatly they're compartmentalized.

Re: Moderna mRNA sequence released to GitHub [pdf]

#172

I wouldn't install beta software on a production system though.

Well we do with anti-malware stuff, when a 0-day comes out and we know there are exploits in the wild and beta software is all we've got.

Luckily in that case there is usually a means to roll back.

Re: Moderna mRNA sequence released to GitHub [pdf]

#174
post #31

I'm sure it's more complex than I grasp as a layperson, but I'm utterly amazed at how simple this _appears_. I get the feeling that this is something I have a better chance of understanding than the average SaaS Terms and Conditions. I expected to have to scroll through pages upon pages of indecipherable text. Instead it's no bigger than a large paragraph of text, and I can easily fit it on my screen.

each one of those letters represents a ~15 atom molecule, so in a way it is a compressed representation

Re: Moderna mRNA sequence released to GitHub [pdf]

#175
post #166

Earlier quoted context omitted.

" but vaccines do not bring in the bacon." As in, "do not generate enough income"? Really? Now?

Yes, really. Typical vaccines are like $5 to $200 or so. And worst of all, usually just one or two doses. For all the horror HIV has wrought, global spending on vaccine development for HIV has been around $1 billion a year for the last few years. In contrast, the USA federal government spends $3 billion a year for HIV antiviral drugs for low-income Americans. $20,000 per patient per year for life. Unsurprisingly, new…

"es, really. Typical vaccines are like $5 to $200 or so"

But since the demand is 14 000 000 000 doses, there should still be a little bit of money in it?

Re: Moderna mRNA sequence released to GitHub [pdf]

#176

Earlier quoted context omitted.

sequence is actually released by Moderna in their patent: https://www.modernatx.com/sites/default/files/US10702600.pdf though they do present multiple sequences, so I guess you'd have to go to the FDA application to figure out exactly which one got used.

Reading the primary claim is fascinating: "A composition, comprising: a messenger ribonucleic acid (mRNA) comprising an open reading frame encoding a betacoronavirus (BetaCoV) S protein or S protein subunit formulated in a lipid nanoparticle." I have a "I'm sure that means something to somebody" feeling. It's also surprising that the remaining claims seem to describe the resulting bits of the sequence, and that that…

Claims are read in the context of the body of the patent and generally known and/or cited knowledge in the field in question. As long as you define precisely what you mean by your terms in the body, you can be as succinct as you want in the claims.

Re: Moderna mRNA sequence released to GitHub [pdf]

#177
post #31

I'm sure it's more complex than I grasp as a layperson, but I'm utterly amazed at how simple this _appears_. I get the feeling that this is something I have a better chance of understanding than the average SaaS Terms and Conditions. I expected to have to scroll through pages upon pages of indecipherable text. Instead it's no bigger than a large paragraph of text, and I can easily fit it on my screen.

"but I'm utterly amazed at how simple this _appears_." Biology is a funny old thing. You can look at that concise description - the orange and so on blocks of a few letters and a few short groupings. Now ATCG are basic building blocks but they consist of quite a lot of stuff. I think it's a bit more complex than that because this is RNA not DNA so ATCG might not be quite right. Each of those bases are horrifically co…

It'd be cool to make an easy-to-use interface, still.

Re: Moderna mRNA sequence released to GitHub [pdf]

#179
post #35

Earlier quoted context omitted.

We aren’t that different from machines, we just need to know more about the CPU and all the co-processors and how the logic gates interact But for now we can inject code to trigger protein configuration via the immune system

> We aren’t that different from machines, we just need to know more about the CPU and all the co-processors and how the logic gates interact Except it is unfortunately not that simple, because it assumes that distinct components such as CPU, co-processors and even logic gates exist in that context, as is totally reasonable to assume on devices created by humans. Abstracting complex machines into distinct components i…

“Imagine a being like nature, wasteful beyond measure, indifferent beyond measure, without mercy and justice, fertile and desolate and uncertain at the same time; imagine indifference itself as a power, how could you live according to this indifference?"

Re: Moderna mRNA sequence released to GitHub [pdf]

#180
post #65

Earlier quoted context omitted.

Umm, isn't that kind of scary? Like could you create a virus with this Ψ that our immune system can't fight at all?

Maybe I'm thinking too simplified here, but wouldn't this only work on the first iteration? After all the virus would replicate with Us in your cells and then the replicas wouldn't have the advantage anymore.

By that point the cell would be producing the associated protein though. Getting it inside the cell is the goal here from what I've read.
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