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Biomarker of Alzheimer's found to be regulated by sleep cycles

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Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#171
post #166
post #133

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Have you tried melatonin? I had something similar to this and taking melatonin 1h before my desired bedtime has changed my life.

Does it make you drowsy in the morning? I typically take 7mg and it helps me fall asleep but I feel drowsy the next day.

It's quite high, you only really need 0.3mg for an effective dose and you get diminishing returns after that in the form of grogginess.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#172
post #117

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There's no literature I'm aware of studying links between DSPD and Alzheimer's. However, DSPD is characterized as delayed sleep...not less sleep. As long as you're getting sufficient sleep and feel rested when you do sleep, I don't think it matters when you do it as it relates to this issue. As someone who's dealt with DSPD in his 20s, I'll refrain from advice. I got no end of people telling me to exercise more, drin…

>As long as you're getting sufficient sleep and feel rested when you do sleep, I don't think it matters when you do it as it relates to this issue. I usually sleep 9-10 hours and feel very tired all day. If I sleep 11-11.5 hours, then I'll feel rested, but this rarely happens. Don't get me wrong, there are plenty of days I have an early meeting morning and sleep for 6-7h, but I will feel even more tired than when I s…

Ever get checked for sleep apnea or the like? It sounds like unrefreshing sleep, it's unlikely that you need more time in bed as usually this makes things worse leading to fragmented sleep / more awakenings.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#173

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The first line of treatment is CBT-I.

I wouldn't start CBT-I without first getting a sleep test, particulary for sleep apnea which can be present without obvious symptoms beyond insomnia or a delayed sleep phase. It's also much more common in young fit people than is often thought.

I would by virtue that CBTi isn't just sleep restriction, the most important component is CBT. At any rate restriction need not be very severe.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#174
post #165

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Reminds me of wozniaks advice: https://supermemo.guru/wiki/Curing_DSPS_and_insomnia

Bookmarked for reading later, I think I suffer from this. I normally can’t fall asleep before 2-4am, even if my body is physically tired I often feel like I can’t turn off my brain, once I’m asleep I sleep well and wake up naturally after 6-8 hours. It does seem cutting off screens an hour or so before bed and melatonin sometimes helps.

I have a threshold that if I surpass quickly becomes a chase. My solution is to go to bed at around 8pm and read until I fall asleep, which is sometimes immediate but never usually much past 10pm. That way, I can wake up fully refreshed at 4am, or I can sleep until 7am if I need it.

I use melatonin to reset my sleep cycle if I mess up and end up staying up all night. A mg or two at around 5pm helps me back into my target range, and from there I usually don't need it.

Routines are important. If I didn't try to actively control it, I'd stay awake until the sun came up and then sleep until noon, and I much prefer working in solitude when I first wake up than when I'm mentally fatigued at the end of a day.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#175
post #150

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>big grain of salt Isn’t the point of the “grain of Salt” to indicate that it is trivial? If so, then by saying “big grain of salt” aren’t you undermining the point of the original statement? I see this regularly and wonder if I am missing something.

> Isn’t the point of the “grain of Salt” to indicate that it is trivial? No, it's from an ancient adage about food being mmore easily swallowed when accompanied by salt. The “grain of salt” you take with a dubious statement with is to make it easier to swallow. A “big grain of salt” is a suggestion that it needs more assistance to be swallowable than a typical target of the saying.

Thank you!

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#176
post #126

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Is it coffee? Or is it caffeine (i.e. tea, etc.)? I consume around 500-1000mg of caffeine a day (very carefully timed so as not to get jitters). I can't handle a higher dose of Adderall XR, so I've embraced my higher caffeine intakes as a way to soothe the mind. That said, I don't care for the flavor of coffee, so I typically consume it via Red Bull/5hr/tablet form.

This is a separate in-vitro study that seems to suggest it's not the caffeine that is helping https://www.frontiersin.org/articles/10.3389/fnins.2018.0073...

Thank you!

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#177
post #90

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I thought this too then I lived in a room without shades for months. Amazing how I started to wake up earlier and earlier and get tired earlier and earlier.

People with the night owl genetics wouldn't care about sunlight.

People with night owl genetics might have a low production of sleep hormone. Or have autism which is linked with a low production of sleep hormone.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#178
post #55

I believe in 100 years we'll look back in horror at our society's casual indifference to routinely waking adolescents, a group with the latest shifted circadian rhythms, wake up before dawn. Much the same way that we look back at horror with the past's casual indifference to smoking.

I think we have it backwards, the problem is going to sleep late.

Go out and look at the some for a couple of minutes whem it rises, it will make the body set the max() brightness to know what is low() and when to start with sleep hormones..

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#179

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I have zero doubts about everything you said. Anecdotally, the last time electricity went down in the whole neighborhood we were forced to use candles and it was .. magical. Stupidly magical.. the light warmth, the decay, the flicker.. my mind went into creative mode right away. It's the opposite of distraction we can get 24/7 these days.

yes, same thing here in the early morning, having it still be dark was a wonderful feeling, and then when power was restored and all the lights came back on outside, i was quite shocked how my good feelings went away... after that, i started to wonder what the whole effect of endless light polution is having on societey...

everything has a dosage, even modernity

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#180
post #105

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I wasn't diagnosed with this but I had the symptoms and the consequences you mentioned. It took a long time to fix. Here's some things I tried. Some may have helped or none may have helped. * I bought blackout blinds and use a sleeping mask (sometimes earplugs) * I bought a bright light ( https://www.amazon.co.uk/gp/product/B07FFJYMVS ) and a smart plug. 15 mins before I wanted to wake up I would have a timer turn on…

Reminds me of wozniaks advice: https://supermemo.guru/wiki/Curing_DSPS_and_insomnia

That's a great resource, thanks for sharing. Maybe I will start drinking in the morning :)
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