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Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

medrxiv.org

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Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

#171

Post by neuronic »

_0ffh wrote: post #148

PSA: Before supplementing Vitamin D, do some research on calcification and Vitamin K2. Or you can trust a random person from the internet and supplement 40mcg K2 mk7 all-trans per every 1000IU of Vitamin D. That seems to be around the usual amount used in studies [1]. I'm not sure if this is the appropriate factor for high Vitamin D dosages of multiple tenths of thousands IU. Personally, I'd be wary of such dosages a…

Why would you be wary? 15min of full body sunexposure will net you ~20,000 IU. Supplementing 8-10,000 IU will not bring you into danger territory by a LONG shot.

Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

#172

Post by valarauko »

cj wrote: post #134
valarauko wrote: post #106

Earlier quoted context omitted.

I'm currently taking 60K IU D3. The dosage is 1 capsule a week, for 8 weeks, and the capsules come 4 to a pack. This is followed by a maintenance dosage of 1 60k capsule once a month.

Is this to treat a medical condition? I'm curious why an acute high dose would be preferable over a lower dose taken daily.

No obvious medical condition, other than a vit D serum level of 15 ng/mL. Depending on who you ask, that's a deficiency. I'm personally less convinced.

It's not quite an acute high dose. The body produces the equivalent of 10,000 IU per day in high sun exposure, so 60K per week tries to achieve that level. I believe the high dosage is simply convenience. The 2K IU daily dose is pretty common as well.

Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

#173

Post by parineum »

nkozyra wrote: post #21
Spooky23 wrote: post #8

Was this known early on about COVID? Early on in the lockdown I noticed that these vitamins were among the kind of weird items completely cleared out of stores. People were very selective... initially all FHD laptops and Chromebooks were gone, along with power strips, ibuprofen, hair clippers, etc.

Vitamin D has been thrown around a lot from the get-go, probably because of its value against other forms of coronavirus including SARS and viral infection in general. My layman's understanding is that supplementation hasn't shown to be effective, meaning D deficiency may be a co-indicator. [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189189/ [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308600/#:~:tex... .

> meaning D deficiency may be a co-indicator

I saw a statistic/study from China that found that only 1 in 7000 cases were exposed outdoors. The link could be as simple as people who spend a lot of time indoors get more exposure to the virus.

The only real action you can glean from that isn't to take supplements, it's don't do what caused those people to be vitamin D deficient which is usually staying indoors.

Maybe it's the vitamin D, maybe it isn't.

Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

#174

Post by caleb-allen »

caseysoftware wrote: post #70
cj wrote: post #38

Earlier quoted context omitted.

The study mentions 1,000 IU D3 dosage. A quick google turns up a rough figure of 60,000 IU "daily for multiple months" can become toxic. You're probably right, most things taken at 100x the normal dose for long period of time are toxic. (Water included)

The largest dosage of D3 I can find on Amazon is 5000 IU in a 240 capsule bottle. To take 60000 IU, you'd have to take a dozen capsules daily, getting a new bottle every 20 days, probably multiple times. While possible, it does seem unlikely.

There is an interesting video about a boy who did just that, by mistaking vitamin gummies for candy:

https://www.youtube.com/watch?v=mZ6nREONy_4

Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

#175

Post by alexbanks »

neuronic wrote: post #168
alexbanks wrote: post #163

Earlier quoted context omitted.

> Since taking a basic multi-vitamin is good anyway, it seems wise to do that. I'm finding it kind of shocking how many people are disputing the value of basic multi-vitamins. It feels like we're being contrarian just for the sake of it. Take a multivitamin. Worst case, your health stays the same and you pee out what you don't need. Best case, maybe you're less susceptible to the harsher symptoms of covid. Seems like…

No, the worst case is you throw money away but I guess the HN crowd doesn't really grasp that there are people who have to consider each dollar/euro/etc... At least take vitamin supplements with proven effect and decent uptake and not garbage filler pills designed to collect snake oil money.

That's a valid point that I've yet to see anyone in this thread make. The arguments against vitamin supplementation in this thread seem to be challenging the validity of supplementation, which was the point of my post.

Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

#176

Post by gnulinux »

carlosfvp wrote: post #131
PudgePacket wrote: post #90

> Patients were administered oral vitamin D3 1000 IU OD I've seen multiple sources say that 1000 IU of vit D is usually insufficient to boost levels, with suggestions of up to 5000 a day. My mothers doctor put her up to 2000 a day because 1000 did nothing to her levels, which were already low.

How did the doctor know her vitamin levels were low? I once asked a doctor if the vitamins in our body can be measured, and he said it can't be done, is not something you can measure.

I regularly blood-test my vitamin D and B levels since I live indoors a lot (not an outside person) and have a slight vit. B absorption problem (I don't absorb it as efficiently as normal people) so I need to take supplements even if I eat healthily.

Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

#177

Post by giardini »

stainforth wrote: post #161
giardini wrote: post #157

Earlier quoted context omitted.

How kind of you to summarize Ioannidis' studies in a single sentence and then dismiss them based on your undoubtedly highly-educated and data-supported opinions, saving readers the drudgery of clicking a link, browsing a noted paper and possibility gaining some enlightenment and ease-of-mind. Perhaps you should write a study about argumentation?

And yet your tactic was the same in effect - your wall of text utlimately tries to lead us to dismiss this post and any research at all. You want the reader to stop thought.

"And yet your tactic was the same in effect - your wall of text utlimately[sic] tries to lead us to dismiss this post and any research at all. You want the reader to stop thought."

Links to an original research article, several supporting but more approachable articles for the everyday reader, and a link to an (excellent) book is a "wall of text" for you? My, my!

OTOH there's little doubt you've "stopped thought"!8-)) Perhaps a nap would help.

Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

#178

Post by bagacrap »

ageitgey wrote: post #2

N=43 (17 given vitamins vs 26 not) Highlights: "Significantly fewer DMB patients than controls required initiation of oxygen therapy subsequently throughout their hospitalization (17.6% vs 61.5%, P=0.006)." "DMB combination in older COVID-19 patients was associated with a significant reduction in proportion of patients with clinical deterioration requiring oxygen support and/or intensive care support. This study supp…

yeah, don't take a multi. The amounts of D and C they put in those things are far lower than what you need to get immunity benefits.

Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

#179

Post by MiroF »

NickM wrote: post #69
partyboat1586 wrote: post #45

Earlier quoted context omitted.

Turning round in a circle three times also doesn't improve your health in general. Getting the right vitamins does improve your health.

Getting too much of many vitamins can harm your health though.

Not true of B12 at least. No known upper limit as of now.

Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

#180

Post by gauravjain13 »

Traubenfuchs wrote: post #19
mikece wrote: post #16

I wonder, when I see stories about studies about treating patients with basic nutrients and vitamins, if a root-cause to consider is that our standard diets are so deprived of essential vitamins and minerals that "treating" someone with what they have been missing causes the body to simply function the way it's supposed to. I haven't read the full study but if it takes into account what someone's diet was prior to th…

You are right and it is no secret: - 40% of US Americans are B12 deficient https://www.livekindly.co/b12-deficiency-genetic-makeup/#:~:... . - 42% are Vitamin D deficient: https://www.cantonmercy.org/healthchat/42-percent-of-america... . - up to 50% are Magnesium deficient: https://www.sciencedaily.com/releases/2018/02/180226122548.h... - 10 - 20% of women are iron deficient: https://www.aafp.org/afp/2007/0301/p671.h…

I’ve often wondered how we come up with daily dose recommendations for vitamins. To the HN hive mind/experts on this topic: What types of research design, data sets, etc. inform these recommendations? Essentially, is this well studied/well understood, and have broad consensus in the medical community?
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