Earlier quoted context omitted.
I am wondering, what kind of impact would the wind have on these projectiles? Or even on ballistic missiles? I would imagine a nuke having such a large explosion that missing the target by a kilometre won't matter too much. But with a kinetic projectile that kind of deviation would not be acceptable (unless we are talking about seriously big projectiles, like in Tunguska etc).
Wind and other transient atmospheric conditions have a major effect. That's why individual unguided projectiles can't reliably hit a target more than about 4 miles away, and even at that range you have to be really lucky. The range from LEO to surface is a lot longer.
Obviously you don't want to do a powered de-orbit for reasons mentioned (you burn fuel & lose kinetic energy). However, if you're flying low enough, couldn't you aerobrake your projectiles after release and have them de-orbit themselves?
For comparison, the X-41/51 scramjet programs appear to be aiming at the mach 5-9 region. So less than 1/2 as fast.
As complicated as the materials science and guidance has to be for any X-71-based projectiles, slowing down and terminal guidance (ablative coatings and sacrificial control surfaces) seem like easier problems than boosting up to ridiculous velocities.
As for tracking, you get the heat bloom as it aerobrakes, but if you manage to keep it coherent through re-entry then the ridiculous speed largely moots that.
At 5 km/s, with a prograde orbit, you're from Istanbul to Beijing about 24 minutes (by my sleepy calculations?). The exercise seems more of a question of "How steep can you dive (aka how much heat can you handle)?" than anything else.
PS: Well, and "How the hell do you communicate-with / sense-from a platform surrounded by air that hot?"