Earlier quoted context omitted.
Yeah the only way to run 4 sticks of DDR5 decently is with Intel. It's a bit of a shame that you can't cram enough RAM to run big models. The most I could get running on 10GB VRAM + 96GB RAM was a REAP'd + quantized version of MiniMax-M2.5
I’m running 128gb on a 9550x now with 4x32gb sticks and it’s terrible. It’s unstsable, post time is about 2 minutes (not exaggerating)and I’m stuck at a lower speed. I’m considering just taking 2 of the sticks out and working with 64gb and increasing my swap partition. The nvme drive is fast at least. This is my first time off intel and I have to say I don’t understand the hype.
You may need to bump up voltages slightly for your CPU's IMC (I needed to on my ryzen 8700F to run 6000 stable). Its CPU sample dependant.
Also as other commenter pointed out, typically 4 sticks will achieve lower stable clocks