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Review of Anti-Aging Drugs

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Re: Review of Anti-Aging Drugs

#161

Post by lurking_swe »

bluGill wrote: post #139
lurking_swe wrote: post #125

Earlier quoted context omitted.

leading a healthy active lifestyle DOES improve the quality of your life. Getting diabetes and injecting yourself daily with insulin is not a quality life. Having trouble walking or playing with your grandkids because one is too fat and has ruined their joints is also not quality. Having a miserable last 10-20 years of life due to a stroke is also not quality. These things don’t mysteriously happen. :) Being able to…

Sorry, I didn't mean to imply do nothing. I meant to caution that your best efforts may be meaningless. I have know several people doing thing right who yet got dieabietes, had strokes, or died young. good diet and exercise is important but it isn't everything

agreed. I can get hit by a bus tomorrow crossing the street, or get a stroke despite my efforts. nothing is guaranteed. Should cherish every day!

Re: Review of Anti-Aging Drugs

#162

Post by nikolay »

JPLeRouzic wrote: post #141
nikolay wrote: post #118

Earlier quoted context omitted.

Autophagy sounds like a great idea... if you completely ignore the Hayflick limit - non-cancerous human cells don't divine indefinitely!

> " human cells don't divine indefinitely! "

I apologize about the typo, but it's true that cells don't divine without a (Hayflick) limit due to telomere shortening. Excessive autophagy is detrimental. The best strategy is to prevent cells from becoming senescent.

Re: Review of Anti-Aging Drugs

#163

Post by Citizen8396 »

bradleyjg wrote: post #107
chasil wrote: post #91

Earlier quoted context omitted.

I have personally reduced my a1c from 6.2 to 5.3, mostly by fasting for 36 hours per week. I already cut refined sugar out of my diet several years ago.

> reduced my a1c And therefore ?

Prediabetes is 5.7 to 6.4- this is a significant improvement.

Re: Review of Anti-Aging Drugs

#164

Post by malfist »

FollowingTheDao wrote: post #159
malfist wrote: post #155

Earlier quoted context omitted.

> You’re saying this like it’s true already Because it is true already? You take an obese person who has a lower quality of life because of their obesity and give them a drug that helps them lose that weight and keep it if, they're literally gaining function and a higher quality of life from it. Today.

Phen-fen helped people lose weight.

Yeah, and? Fen-phen was a drug controversially approved in April 1996 and withdrew from market September 1997.

GLP-1s aren't remotely similar. Their approval was 20 years ago and have been in used by diabetics since.

Re: Review of Anti-Aging Drugs

#165

Post by JPLeRouzic »

nikolay wrote: post #162
JPLeRouzic wrote: post #141

Earlier quoted context omitted.

> " human cells don't divine indefinitely! "

I apologize about the typo, but it's true that cells don't divine without a (Hayflick) limit due to telomere shortening. Excessive autophagy is detrimental. The best strategy is to prevent cells from becoming senescent.

No worries!

Not all cells divide (neurons and some muscle cells don't divide); some cells divide very slowly. And in some cases telomeres may be repaired but this increases the risk of cancer [0]

https://biologyinsights.com/what-is-telomere-repair-and-is-i...

Re: Review of Anti-Aging Drugs

#167

Post by dinfinity »

sigmoid10 wrote: post #43
bob1029 wrote: post #20

> Fast for short intervals regularly, and longer fasts as they feel good to you. You can effectively do this every day if you just eat once per day. When I was properly obese, this technique resulted in rapid weight loss. Zero exercise was required to see results, which was good at the time because the not eating part was about all I could handle. Being in a fasted state is as close as you can get to actually reversi…

While autophagy does correlate with fasting and some studies link it to health markers, it should be noted that it usually takes at least 18 hours of continued fasting to even start and only goes into full swing after 48 to 72 hours. It is also an extreme cell response that is associated with high levels of cellular stress, which might have understudied long term detrimental effects. A simple calorie reduction either…

> autophagy [...] usually takes at least 18 hours of continued fasting to even start

False. That would mean cellular debris would pile up unconstrained for pretty much everybody, which is clearly absurd.

> It is also an extreme cell response that is associated with high levels of cellular stress

Also false. It is a very essential cellular process. Read up on it, please.

Re: Review of Anti-Aging Drugs

#168

Post by sigmoid10 »

Melatonic wrote: post #156
sigmoid10 wrote: post #43

Earlier quoted context omitted.

While autophagy does correlate with fasting and some studies link it to health markers, it should be noted that it usually takes at least 18 hours of continued fasting to even start and only goes into full swing after 48 to 72 hours. It is also an extreme cell response that is associated with high levels of cellular stress, which might have understudied long term detrimental effects. A simple calorie reduction either…

Personally I'd add 'consume and make tons of fermented food' to that list and also eat lots of prebiotics. Gut health is key to so many aspects of a healthy life - I have to imagine it helps with longevity (and lower stress). Nobody likes having stomach pain! People love their probiotic pills but I'm not convinced - the amount of beneficial microbes is measured at bottling or production and who knows how many survive…

Probiotics fall into the same category as all other supplements: i.e. they can have some short term effects if your diet is really bad or you are recovering from GI disease, but there is not much evidence regarding general health improvement. And you also have the same issues as with all food supplements in that they are not FDA regulated or approved. So even if you think you actually need a particular dosage, you can't rely on what is written on the packaging. A balanced diet is a much better and healthier approach without any downsides.

Re: Review of Anti-Aging Drugs

#169

Post by nikolay »

JPLeRouzic wrote: post #165
nikolay wrote: post #162

Earlier quoted context omitted.

I apologize about the typo, but it's true that cells don't divine without a (Hayflick) limit due to telomere shortening. Excessive autophagy is detrimental. The best strategy is to prevent cells from becoming senescent.

No worries! Not all cells divide (neurons and some muscle cells don't divide); some cells divide very slowly. And in some cases telomeres may be repaired but this increases the risk of cancer [0] https://biologyinsights.com/what-is-telomere-repair-and-is-i...

I'm fully aware of cancer risks with substances such as astalagus extract, but maybe telomerase activators can be combined with anti-cancer strategies such as fasting, etc.

Re: Review of Anti-Aging Drugs

#170

Post by sigmoid10 »

dinfinity wrote: post #167
sigmoid10 wrote: post #43

Earlier quoted context omitted.

While autophagy does correlate with fasting and some studies link it to health markers, it should be noted that it usually takes at least 18 hours of continued fasting to even start and only goes into full swing after 48 to 72 hours. It is also an extreme cell response that is associated with high levels of cellular stress, which might have understudied long term detrimental effects. A simple calorie reduction either…

> autophagy [...] usually takes at least 18 hours of continued fasting to even start False. That would mean cellular debris would pile up unconstrained for pretty much everybody, which is clearly absurd. > It is also an extreme cell response that is associated with high levels of cellular stress Also false. It is a very essential cellular process. Read up on it, please.

You should read up on the literature. There isn't much, but this part is pretty well established.
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