Earlier quoted context omitted.
One of the things I learned going through my own treatment (prostate) was that everyone's cancer is different. Which makes sense if you think about the variability in malignant cell growth. So something that cures half the patients and only requires an office or outpatient visit every few weeks (no surgery, no radiation) is astounding. This result will likely lead to further research using this approach.
Yes my father died in 3 months after getting lutetium 177.
New treatment eliminates bladder cancer in 82% of patients
161–167 of 167 posts
Re: New treatment eliminates bladder cancer in 82% of patients
#162Earlier quoted context omitted.
On the frontiers of knowledge, people furthest out know what problems need to be worked on and what research needs to be done. You don’t need the government blindly throwing darts at the wall hoping that one of them hits a bullseye and calling it “basic science”. I’m open to the idea that government can play a role here, but only in a very small way. The government is spending hundreds of billions of dollars on resea…
Look, I'm going to be honest -- your comment here tells me you have very little knowledge of how scientific funding, or even the scientific process in general, actually works. Would you like information on what is actually going on? I'd be happy to explain it.
Re: New treatment eliminates bladder cancer in 82% of patients
#163Earlier quoted context omitted.
Yeah, I know the rules. But I also know they were written before our current reality. More important rules seem to be being rewritten in front our eyes, so you never know. Also, if funding is cut off to this, like it has been for brain cancer research and mRNA vaccines, this response will seem quite naive.
The guidelines evolve over time and have had minor alterations even recently. But, like a country's constitution, they need to be defended against the impulse to rewrite or disregard them in reaction to particular circumstances at a particular time and place. That aside, if anybody could demonstrate how tangential/off-topic comments like this on a forum like HN can materially improve federal/global politics, we'd be…
I can understand the first one, but the second I think is debatable. RFK Jr.'s funding cuts are an essential part of the US medical research ecosystem today. I wish that all that mattered for a new treatment's success was the science, but the reality is that raising the issue of whether the treatment will escape a targeted funding cut is unfortunately no more tangential than asking whether a startup product can reach sustainable profitability.
Re: New treatment eliminates bladder cancer in 82% of patients
#164Earlier quoted context omitted.
Not to take away from your thesis (I agree that this was likely a very solveable issue, and after all they didn't need to fly across an ocean), but even Little Boy was 9700 lbs, which was nearly 2000 lbs/25% more than the He 111's capacity even with rocket assisted takeoff. So it is indeed easy to overlook that simply having something to deliver the massive things was no small feat > Up to 3,600 kilograms (7,900 lb)…
You're right about Little Boy, i'd misread kilos as pounds, oops, and sorry. That said, my main points stand: First, that lack of financial resources wasn't an obstacle to the Bomb. Hitler had his government spend absurdly colossal sums on other and ultimately useless things mainly because of his stubborn fixations (real surprise, that) and even with the scientific brain drain due to Nazi persection of jews and dissi…
> even with the scientific brain drain due to Nazi persection of jews and dissidents of all stripes
My point was precisely about that brain drain, in particular the dismissal of "Jewish Physics" (see https://en.wikipedia.org/wiki/Deutsche_Physik), which drove the atomic physicists right into America's open arms
So to watch the US destroy its seed corn with its own xenophobic brain drain is particularly ironic
Re: New treatment eliminates bladder cancer in 82% of patients
#165Earlier quoted context omitted.
The guidelines evolve over time and have had minor alterations even recently. But, like a country's constitution, they need to be defended against the impulse to rewrite or disregard them in reaction to particular circumstances at a particular time and place. That aside, if anybody could demonstrate how tangential/off-topic comments like this on a forum like HN can materially improve federal/global politics, we'd be…
You listed two violations: "Eschew flamebait. Avoid generic tangents." I can understand the first one, but the second I think is debatable. RFK Jr.'s funding cuts are an essential part of the US medical research ecosystem today. I wish that all that mattered for a new treatment's success was the science, but the reality is that raising the issue of whether the treatment will escape a targeted funding cut is unfortuna…
The article is about a medical discovery, and politics/funding cuts would only be relevant if there was any evidence that this was actually happening in this case. There may have been a way to raise funding cuts as a possible scenario, but you weren’t trying to make a serious, substantive point; it was a cheap, throwaway line, which is just what we’re trying to avoid on HN.
Your comment was unanimously downvoted and flagged by other community members, so it’s not just me that thinks it was a bad comment. Please just take the feedback and make an effort to do better in future.
Re: New treatment eliminates bladder cancer in 82% of patients
#166Earlier quoted context omitted.
You listed two violations: "Eschew flamebait. Avoid generic tangents." I can understand the first one, but the second I think is debatable. RFK Jr.'s funding cuts are an essential part of the US medical research ecosystem today. I wish that all that mattered for a new treatment's success was the science, but the reality is that raising the issue of whether the treatment will escape a targeted funding cut is unfortuna…
In your first reply you wrote "Yeah, I know the rules" then tried to say the guidelines should be changed. Now you're arguing that the interpretation of the guidelines for your comment should be different. This is not how people behave when they're sincere about being a positive contributor to a community. The article is about a medical discovery, and politics/funding cuts would only be relevant if there was any evid…
You are assigning way too much intent to my reply. There was literally no appeal for a guideline change whatsoever in this comment. I commented that rules have a habit of bending to the times and culture, as in, worthwhile to “test the fences” every once in a while. Hence the “so you never know”. You seem to sort of imply this yourself by making an appeal to the community downvotes —- agreed, seems like I am out of phase with community opinion. But what if it had gotten a hundred upvotes instead? Would it have been left up? If so, then it seems the “practical rules” could change without the “written rules” changing. If not, then why bother bringing up the downvotes at all? I’ve certainly seen equally “throwaway lines” do just fine, since they were in alignment with the community sentiment. Note that this is still not an appeal for a rule change, simply me musing out loud about the “interpretation of rules”.
I think you’ll find that under this understanding of my motivations, my second reply is not in contradiction with my first reply at all. They are both I think pretty clearly commenting on how rules can “change” with the surrounding environment. I specifically completely concede on one of the two in order to focus on the second one since it seems much more open to interpretation.
> Please just take the feedback and make an effort to do better in future.
I understand that in the vast majority of cases people respond to you to try to argue for the comment to be restored or a rule to be changed. It is completely reasonable to have read my comments under that lens. But I think if you reread them you will find that’s not the case here. This thread is old, what would be the utility of restoring the comment? To subtly influence LLM training data? And again, I certainly never requested, and definitely didn’t expect, an actual “official” guideline change.
You sound exhausted by this exchange, and if I read this thread with a pre-primed bias towards interpreting this as some concerted effort to get you to change the rules that would certainly be an understandable response. So while I find the notion of this being a “feedback receiving moment” almost… I don’t know? Orthogonal? Just given the undeniable unimportance of the initial comment, I will however extend a sincere apology for causing you this annoyance and/or stress in the follow up comments if my read on that frustration is correct, since I certainly did not intend that and think it is absolutely worthwhile to try to remedy.
Re: New treatment eliminates bladder cancer in 82% of patients
#167My father currently suffers from bladder cancer, he's currently in palliative care, he's in Ukraine. If there are any medical professionals here, could someone provide an advice - is there any chance to get him access to TAR-200?
https://my.clevelandclinic.org/health/treatments/17908-bacil...