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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#161

Post by VectorLock »

matwood wrote: post #68
jjice wrote: post #54

Earlier quoted context omitted.

I was kind of scared of these when Ozempic starting picking of steam for weight loss. I was worried that this would be having more negative effects. Turns out, generally speaking, if used with you doctor, these things are pretty safe, especially comparatively to some of the negatives of being overweight. And then I saw some of the stories on HN about how it's changed peoples lives for the better. And then people in m…

And not just weight loss, but the people I know on GLP-1's have also significantly cut back on alcohol. I think there are ongoing trials around GLP-1's and general addiction.

It helped me cut back on my drinking significantly. I'm not an every day drinker but a weekend binge drinker and the amount I drink when I drink is down by I'd estimate by around half or more.

Re: Ozempic shows anti-aging effects in trial

#162

Post by XorNot »

throwawaylaptop wrote: post #151
leidenfrost wrote: post #126

Earlier quoted context omitted.

But it's not. What you're referring to, is the basic concept of thermodynamic calorie in/calorie out. Yes, you can "just" reduce food and lose weight if you hit deficit numbers. But if you don't do it correctly, you'll feel like trash, you'll suffer bad cravings, and put yourself in a stressful mental situation for days, possibly putting your job at risk. You have to: - Eat less than what you're already eating - But…

Inaccurate in my opinion. Let's say you eat 2500 calories a day usually. But you want to lose weight so you reduce it to 1800. Except your calories are from pop tarts. If you ate 100 calories of pop tarts every hour you're awake for total of 1800 calories... At the end of the month you'd be fatter. If you ate 1800 calories of pop tarts once a day in 1 hour, you might maintain weight or loose a little. Maybe. If you h…

> If you ate 100 calories of pop tarts every hour you're awake for total of 1800 calories... At the end of the month you'd be fatter.

This is thermodynamically impossible unless your daily calorie use is less then 1800 calories.

Re: Ozempic shows anti-aging effects in trial

#163

Post by j2bax »

noah_buddy wrote: post #153
falcor84 wrote: post #102

Earlier quoted context omitted.

I'm not a Catholic, but wasn't the idea of an indulgence that God intentionally allowed an alternative path to redemption, such that if you buy an indulgence, you are (at least by their definition) worthy and deserving? I always thought of this as essentially the same idea as with Civ allowing you different paths to victory.

My point was that many people view ozempic and other drugs like Martin Luther viewed buying an indulgence: a cheat for the undeserving.

I thought Martin Luther's issue was more with the organization selling indulgences than the undeserving buying them. He preached justification by faith alone. Not some org selling justification.

Re: Ozempic shows anti-aging effects in trial

#164

Post by aswegs8 »

HocusLocus wrote: post #98
tzs wrote: post #76

Earlier quoted context omitted.

Here's an article that answers your question [1]. It in the second bullet point near the top. [1] https://trial.medpath.com/news/5c43f09ebb6d0f8e/ozempic-show...

Yes, epigenetic clocks discovered in 2010 and even the researcher who discovered them might feel insulted by the phrase of a prescription drug declaring "reverse biological aging 3.1 years"

If you're really interested in that and not just trolling, these are the measures used by the study:

After adjustment for sex, BMI, hsCRP, and sCD163, semaglutide significantly decreased epigenetic aging: PCGrimAge (-3.1 years, P = 0.007), GrimAge V1 (-1.4 years, P = 0.02), GrimAge V2 (-2.3 years, P = 0.009), PhenoAge (-4.9 years, P = 0.004), and DunedinPACE (-0.09 units, ≈9 % slower pace, P = 0.01). Semaglutide also lowered the multi-omic OMICmAge clock (-2.2 years, P = 0.009) and the transposable element-focused RetroAge clock (-2.2 years, P = 0.030).

Re: Ozempic shows anti-aging effects in trial

#165

Post by dawnerd »

jjice wrote: post #54
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

I was kind of scared of these when Ozempic starting picking of steam for weight loss. I was worried that this would be having more negative effects. Turns out, generally speaking, if used with you doctor, these things are pretty safe, especially comparatively to some of the negatives of being overweight. And then I saw some of the stories on HN about how it's changed peoples lives for the better. And then people in m…

The same thing with keto. People will swear it's unhealthy but like, the alternative (outside of Ozempic and co) is being overweight...

Re: Ozempic shows anti-aging effects in trial

#167

Post by themafia »

smiley1437 wrote: post #65
hollerith wrote: post #28

Earlier quoted context omitted.

I'm not even ready to concede that it is a good weight-loss drug -- but then I haven't really investigated much, so I'm just repeating what I heard from researcher Ben Bikman and maybe other researchers. I heard that most people choose to discontinue it after 4 or 5 years or less, regain most or all of the weight, then refuse to go back on it.

Tirzepatide (and likely other GLPs) have limitations that are rarely brought up in the general media - Patients have about 72 weeks to reach maximum loss, they don't lose any more weight after 72 weeks even on the highest dose. - Patients appear to immediately gain the weight back as soon as they stop taking it. It's right in the phase 3 trial outcomes paper: https://pmc.ncbi.nlm.nih.gov/articles/PMC10667099/ I suspe…

> I suspect that this info is intentionally down-played so that it doesn't affect sales.

Yea, hard to figure out why drug companies keep producing "Faustian bargains" in our current system. What galls me is people assume the best for new drugs instead of forcing the _for profit_ entity to prove it's actually safe and useful.

To the extent that, reliably, the first comment on these posts on Hacker News are some wishy washy anecdotal emotional blackmail garbage that completely obfuscates the point and runs direct interference for these large profitable organizations.

To the extent that it's hard to believe that these posts even on this tiny corner of the internet aren't bought and paid for. We live in a society that cherishes organized crime and denigrates hard work. I would not look forward to "new drugs" in this regime.

Re: Ozempic shows anti-aging effects in trial

#168

Post by quickthrowman »

mullingitover wrote: post #135
matwood wrote: post #68

Earlier quoted context omitted.

And not just weight loss, but the people I know on GLP-1's have also significantly cut back on alcohol. I think there are ongoing trials around GLP-1's and general addiction.

The cynic in my thinks this will its undoing. Some huge fraction of alcohol profits come from a small portion of drinkers. If these G* peptides help these poor people their drinking under control, it would take a huge wrecking ball to the profits, and thus to the taxes. Can't have that.

Reduced healthcare, policing, and other costs that are paid for with tax dollars from lower alcohol consumption would almost certainly be a net gain over the piddly tax revenue from alcohol consumption sales.

Re: Ozempic shows anti-aging effects in trial

#169

Post by dawnerd »

leidenfrost wrote: post #126
kulahan wrote: post #67

Earlier quoted context omitted.

I think many people confuse simple with easy. It IS simple to reduce your weight. There are like, two things you need to do. It is, however, VERY hard to actually do those things.

But it's not. What you're referring to, is the basic concept of thermodynamic calorie in/calorie out. Yes, you can "just" reduce food and lose weight if you hit deficit numbers. But if you don't do it correctly, you'll feel like trash, you'll suffer bad cravings, and put yourself in a stressful mental situation for days, possibly putting your job at risk. You have to: - Eat less than what you're already eating - But…

That's exactly why I liked being on keto. Never felt hungry, had way more energy, mental health improved a lot. No other diet had those effects. I've been off it for a while and I feel gross again.

Re: Ozempic shows anti-aging effects in trial

#170

Post by DharmaPolice »

jjice wrote: post #139
matwood wrote: post #68

Earlier quoted context omitted.

And not just weight loss, but the people I know on GLP-1's have also significantly cut back on alcohol. I think there are ongoing trials around GLP-1's and general addiction.

I've heard similar for gambling, and as one of the sister comments said, things like video games. I'm so curious to understand _why_ that effect is there, but I've heard this so many times now that I do believe that it exists in some capacity. Such an interesting world we're opening up here.

Every person I know who tried to give up smoking has the same story - they were successful for a while and then they encountered some stressful moment (exam, work deadline, etc) and they fell off the wagon. One explanation could simply be that normally we have food stresses which manifests in general stress which we relieve via video games or whatever else. If these drugs turn down the volume of hunger then maybe this has the benefit of reducing the need for stress relieving behaviours in general.
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