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Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

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Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#161

Post by mbostleman »

aantix wrote: post #128
mbostleman wrote: post #22

Earlier quoted context omitted.

Exactly. I see all these breathless claims of new uses and how wonderful this drug is and wonder when the other shoe is going to drop.

You're getting downvoted because you didn't even care to do a simple Google search as to when the first GLP-1 was released. 2005. Almost 20 years. We have the data.

Actually I recently listened to a fascinating hour long interview with Lotte Bjerre Knudsen (ACQ2 podcast) from which I learned that the original research started in the early 90s. I'm not an authority but I'm pretty well aware of the history. However, I'm still waiting for the other shoe to drop if you don't mind.

And I don't care about votes up or down. But I appreciate your theory on how they're playing out!

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#162

Post by RoyalHenOil »

BoingBoomTschak wrote: post #101
lazyasciiart wrote: post #64

Earlier quoted context omitted.

This is like asking why ADHD patients don’t just get over it by focusing more.

So easy to invent imaginary diseases to cover for decadent lack of willpower and portray a decent life hygiene as something as heroic as firewalking or quitting crack.

My mom is obese because she developed an autoimmune disorder while she was pregnant with me that attacks her thyroid. She has extremely abnormal thyroid cells that have to be biopsied twice a year and she has to take daily thyroid medication or she will die. She is about to start on Ozempic as well because the thyroid medication is not enough.

To manage her disease, she eats much less and much healthier (e.g., steamed kale for dinner every night) than everyone else in my family, and yet she is the obese one amongst us.

Please stop acting like life-saving drugs are evil and everything can be managed through willpower alone. My mom would be dead without modern medical science, and I would have died in the womb with her.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#163

Post by throwaway041207 »

RoyalHenOil wrote: post #152
throwaway041207 wrote: post #124

Earlier quoted context omitted.

No prob. I noticed that I did not want to drink the day after my first shot. It was that fast. If anything the closest I came to drinking came from routine, not desire. That is to say, what is an afternoon watching football if not with a beer in hand? But I was able to move past that. One thing I should make clear, no matter how heavy a drinker I have been at times in my life, including with liquor, I have never had…

Did you have any withdrawal symptoms after stopping alcohol so suddenly?

I did not, but like I said above I've never had physical addiction such that it caused serious withdrawal symptoms (night sweats, seizures, etc have never been an issue for me), so I'm lucky in that respect. Mostly just tremors or what not when I'm on a string of binge drinking nights. I'm a big guy so I don't know if that's why, or just that I am lucky. In the last decade or so I primarily drink beer, mostly because I'm a very fast drinker and I will drink everything under the roof when I get a full head of steam, so I defensively avoid keeping liquor around.

My sleep has been pretty hosed up since I started but it wasn't like it was great before. I am also probably suffering from sleep apnea and I'm hoping to address that soon as I probably have another 4-6 months at the current weight loss rate before I am at a normal BMI.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#164

Post by cthalupa »

consteval wrote: post #157
thefz wrote: post #154

Earlier quoted context omitted.

Lol, no. There are countries in which obesity is nonexistent.

Typically, because less food is available in day-to-day life. If I sold cigs on every street corner in a "skinny" country like Japan, how confident are you that I wouldn't create a smoking culture? This is not a matter of motivation or discipline. Such thinking is short-sighted.

> If I sold cigs on every street corner in a "skinny" country like Japan, how confident are you that I wouldn't create a smoking culture?

Considering Japan has long been one of the highest per capita consumers of tobacco, apparently it's quite likely ;)

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#165

Post by BoingBoomTschak »

RoyalHenOil wrote: post #162
BoingBoomTschak wrote: post #101

Earlier quoted context omitted.

So easy to invent imaginary diseases to cover for decadent lack of willpower and portray a decent life hygiene as something as heroic as firewalking or quitting crack.

My mom is obese because she developed an autoimmune disorder while she was pregnant with me that attacks her thyroid. She has extremely abnormal thyroid cells that have to be biopsied twice a year and she has to take daily thyroid medication or she will die. She is about to start on Ozempic as well because the thyroid medication is not enough. To manage her disease, she eats much less and much healthier (e.g., steame…

Are your seriously implying that your special case is statistically significant or that people like me are against the use of medicine for these? Your blog post completely misses the point: I didn't write imaginary just for kicks.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#166

Post by ASalazarMX »

declan_roberts wrote: post #8

How do you isolate this from the therapeutic benefits of simply losing weight and being skinny?

It might help knowing that Ozempic will not make you skinny. IIRC it increases the effects of a healthy lifestyle change by 15%, effect which is lost if you leave it. The life style change (activity and nutrition) alone is more important, cheaper, and as permanent as you want it to be.

Losing weight is still a hard endeavor.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#167

Post by jewayne »

Someone1234 wrote: post #105
jewayne wrote: post #97

Earlier quoted context omitted.

Don't dismiss the most important question -- does semaglutide really have any effects outside its current intended use for diabetes and weight loss? In other words, would a thin, metabolically healthy person benefit from taking semaglutide? So far, all of the wonderful benefits from taking the drug seem to be explainable by reduced caloric intake / weight loss / better glucose control in overweight and/or diabetic pe…

> In other words, would a thin, metabolically healthy person benefit from taking semaglutide? That's what this thread is about; and multiple other studies looking at different diseases/illnesses/addictions. Time will tell. It is currently approved for T2 Diabetes and Obesity.

There's also the intriguing possibility that many other diseases and even addictions have a heretofore-unknown metabolic component. The idea of some addictions -- even to things like heroin or gambling -- being partially metabolic does not seem far-fetched to me.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#168

Post by hollerith »

llamaimperative wrote: post #96
VyseofArcadia wrote: post #85

Earlier quoted context omitted.

> barring any life threatening long term side effects There's the rub. We have not been prescribing semaglutide very long, and I won't trust it until we've had enough time to suss out long term side effects. My father was on a long-term maintenance dose of immunosuppressant (I think prednisolone, but I could be misremembering) following his kidney transplant. When it was first prescribed to him, the long term side ef…

> There's the rub. We have not been prescribing semaglutide very long, and I won't trust it until we've had enough time to suss out long term side effects. We've been prescribing GLP-1s for almost 20 years now. Not to say they all should behave identically, but from a Bayesian inference perspective these things really do appear to be quite safe.

>We've been prescribing GLP-1s [for diabetes] for almost 20 years now

The dosage though for losing weight is 3 or 4 times the dosage for diabetes.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#169

Post by ebiester »

mbostleman wrote: post #27
declan_roberts wrote: post #8

How do you isolate this from the therapeutic benefits of simply losing weight and being skinny?

And how do you isolate being skinny because you are regularly active and eat well vs. being skinny because you are sedentary and eat garbage but then chase it down with a drug?

I think it's worth looking at the people taking it. While there is definitely nutritional education that needs to happen in behavior intervention, the key benefit to Ozempic is that people talk about it "turning down the food noise."

Those choices become easier when you have assistance.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#170

Post by aantix »

thefz wrote: post #146
Someone1234 wrote: post #7

Earlier quoted context omitted.

With the constant stream of positive news around GLP-1s, and ever-growing list of things they treat, we may all wind up on some dose with only the dose varying depending on what illness they're targeting.

Why would taking a drug you don't need for the rest of your days be a good thing?

what's the alternative?

Struggling with food, being extremely overweight the rest of your life, and not being able to play with your kids because of it?

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