Lowering the algorithmic upper bound for a core NP-complete problem is always extremely interesting. However, this is not necessarily related to improving runtime for practical implementations solving the problem in question. Solvers for mixed integer programming (MIP) use a lot of algorithms in conjunction with loads of heuristics. Building up the library of heuristics and strategies is a crucial part of why the imp…
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There are, instead, languages that are NP-complete, for which we hypothesize that there are no polynomial-time algorithms for, because that would imply P=NP. It's a further unproven hypothesis that NP-complete languages have no sub-exponential time algorithms (the "exponential time hypothesis").