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Vitamin D and Depression (2020)

ncbi.nlm.nih.gov

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Re: Vitamin D and Depression (2020)

#161

Post by throwaway09223 »

alwillis wrote: post #132
phkahler wrote: post #113

Earlier quoted context omitted.

>> The medical community is full of contradictions. We added iodine to salt to prevent deficiency, then decades later told everyone to avoid salt. I've found iodine to be a huge piece of the puzzle - certainly not a panacea but one of several go to solutions.

The American Heart Association recommends no more than 1500 milligrams of sodium per day. Because sodium is being added to packaged and processed foods, the average American was getting way more sodium than the recommended amount. And given the number of obese people and those with hypertension who are salt-sensitive, lots of people were getting way more sodium than was healthy for them.

Well, the basis for the AHA recommendation is probably bogus. So there's that issue as well.

Re: Vitamin D and Depression (2020)

#162

Post by voldacar »

TameAntelope wrote: post #68
carabiner wrote: post #3

Earlier quoted context omitted.

I live in Seattle and have been depressed for a while. I had my Vitamin D3 levels checked via blood test, and they were really low. Started taking 5,000 IU per day, and I feel exactly the same as before.

5k IUs is well beyond anything your body has a use for, and in fact is above what your body can tolerate! [0] > RDA: The Recommended Dietary Allowance for adults 19 years and older is 600 IU daily for men and women, and for adults >70 years it is 800 IU daily. > UL: The Tolerable Upper Intake Level is the maximum daily intake unlikely to cause harmful effects on health. The UL for vitamin D for adults and children ag…

The "tolerable upper limit" for vitamin D is set absurdly low.

I have perused the literature on D toxicity and each case involved someone taking at least 100k IU per day, and usually way more than that. I take 50k IU per day every winter and have never had an issue. Blood calcium levels normal, etc

5k IU is an average dose and will absolutely not cause harm.

Re: Vitamin D and Depression (2020)

#163

Post by dredmorbius »

treeman79 wrote: post #101
interactivecode wrote: post #79

Earlier quoted context omitted.

What dose and diet changes did you do?

3,000u daily. Switched to AIP diet. Six months earlier had started. Started magnesium, b12, fish oil, Vit E. Now I take a 5000u/k2 combo. Now on LDN in addition That seems to be the final major piece to fully normal life.

AIP diet: autoimmune protocol diet.

https://www.healthline.com/nutrition/aip-diet-autoimmune-pro...

Re: Vitamin D and Depression (2020)

#164

Post by hattmall »

alliao wrote: post #147
supertofu wrote: post #60

Earlier quoted context omitted.

Anecdata: I grew up in LA. I was always relatively healthy. Moved to NYC. Developed autoimmune disease by my 6th year in NYC. I often wonder if I would have developed the disease if I had stayed in LA.

people in the past would grab a small jar full of dirt from home and drink it whenever countering some ailment, I actually think that'd still work due to the recent researches on gut bacterial and it's influences on immune system and all...

Who, where, and when? Not doubting just curious about the practice.

Re: Vitamin D and Depression (2020)

#165

Post by hattmall »

kingcharles wrote: post #67
lordentropy wrote: post #12

Daily morning and afternoon exposure to bright light might actually be more important to reducing depression than direct vitamin D supplementation. Low vitamin D might just be an indicator that you are not getting enough sunlight. Sunlight also affects melatonin and serotonin levels, and synchronizes your Circadian rhythm. Not sure why that article doesn't talk about Seasonal affective disorder (SAD), and how bright…

I just went over 8 years without seeing the sun (jail). I wonder what the long term effects are?

Gahdam, they never put you on the yard?

Re: Vitamin D and Depression (2020)

#166

Post by phs318u »

BiteCode_dev wrote: post #65
AnthonBerg wrote: post #42

Earlier quoted context omitted.

Sunlight’s effects on body chemistry also have a damping effect on inflammation. It’s a funny thing. Sunlight has an impact on many chemical processes in and on the body. One example: Our skin is coated with a bunch of chemicals. There’s a number of different acidic chemicals. These are known as the “acid mantle”: https://en.wikipedia.org/wiki/Acid_mantle One of these substances is urocanic acid . The body manufactur…

And yet lots of dermatologists will tell you to avoid sunlight. The medical community is full of contradictions.

> The medical community is full of contradictions.

Looking after our physical and mental health via modulation of multitudes of interrelated bodily systems and their unique chemistry and biology is a massive multivariate optimisation problem.

However, there are reasonable heuristics we can use as a guide for better outcomes, for example, "spend more time in nature" - it's probably no coincidence that doing so is reasonably good for us given we've effectively evolved over many millenia to make the most of "being in nature".

Re: Vitamin D and Depression (2020)

#167

Post by TameAntelope »

voldacar wrote: post #162
TameAntelope wrote: post #68

Earlier quoted context omitted.

5k IUs is well beyond anything your body has a use for, and in fact is above what your body can tolerate! [0] > RDA: The Recommended Dietary Allowance for adults 19 years and older is 600 IU daily for men and women, and for adults >70 years it is 800 IU daily. > UL: The Tolerable Upper Intake Level is the maximum daily intake unlikely to cause harmful effects on health. The UL for vitamin D for adults and children ag…

The "tolerable upper limit" for vitamin D is set absurdly low. I have perused the literature on D toxicity and each case involved someone taking at least 100k IU per day, and usually way more than that. I take 50k IU per day every winter and have never had an issue. Blood calcium levels normal, etc 5k IU is an average dose and will absolutely not cause harm.

> "I have perused the literature"

...and you are?

> 5k IU is an average dose and will absolutely not cause harm.

This is wildly irresponsible to post, and should be removed from HN.

Re: Vitamin D and Depression (2020)

#168

Post by refurb »

BiteCode_dev wrote: post #65
AnthonBerg wrote: post #42

Earlier quoted context omitted.

Sunlight’s effects on body chemistry also have a damping effect on inflammation. It’s a funny thing. Sunlight has an impact on many chemical processes in and on the body. One example: Our skin is coated with a bunch of chemicals. There’s a number of different acidic chemicals. These are known as the “acid mantle”: https://en.wikipedia.org/wiki/Acid_mantle One of these substances is urocanic acid . The body manufactur…

And yet lots of dermatologists will tell you to avoid sunlight. The medical community is full of contradictions.

Human biology is made up a number of interacting systems, negative and positive feedback loops and other biochemical pathways.

If you focus on individual mechanisms, it looks like contradictions, but as a whole it makes sense.

Sunlight is beneficial for vitamin D production, but harmful when it comes to UV damage.

Both can be true and not contradictory.

Re: Vitamin D and Depression (2020)

#169

Post by TameAntelope »

ekianjo wrote: post #159
dragonwriter wrote: post #128

Earlier quoted context omitted.

No, 600 IU (15mcg) is the actual RDA. There's a lot of belief that it's an error, but it's not a typographical error.

The actual RDA is not correct.

It is more correct than the research that shows otherwise.

Re: Vitamin D and Depression (2020)

#170

Post by Sargos »

TameAntelope wrote: post #167
voldacar wrote: post #162

Earlier quoted context omitted.

The "tolerable upper limit" for vitamin D is set absurdly low. I have perused the literature on D toxicity and each case involved someone taking at least 100k IU per day, and usually way more than that. I take 50k IU per day every winter and have never had an issue. Blood calcium levels normal, etc 5k IU is an average dose and will absolutely not cause harm.

> "I have perused the literature" ...and you are? > 5k IU is an average dose and will absolutely not cause harm. This is wildly irresponsible to post, and should be removed from HN.

Are you sure? 5k being a safe average dose seems to be corroborated across the internet and the abstracts of some papers I've seen.
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