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Biomarker of Alzheimer's found to be regulated by sleep cycles

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Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#161

Earlier quoted context omitted.

What is the logic that is holding your reasoning together? A lot of "hustling" culture actually ephasizes good habits including hardcore sleep scheduling, good nutrition and excercise?

And a lot of it doesn't.

So it sounds like a null hypothesis at best?

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#162
post #78

Earlier quoted context omitted.

All cause mortality is absurdly higher if you use drugs to sleep, including OTC stuff[0]. So, probably not. Almost certainly same story with other "meds" that dipshits pop like popcorn[1]. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883191/ [1] https://www.nhs.uk/news/medication/widely-used-class-drugs-l...

"Dipshits" is an incredibly rude way to describe people who are most likely just ignorant.

I think people who stick heaps of fruit salad pills into their gob because "muh science" are, in fact, dipshits. Darwin award winning dipshits. Plenty of "merely ignorant" people have the common sense required to refrain from shoving grams of factory produced mystery chemicals down their throats because some marketer convinced them it might be a good idea.

I realize there is a large contingent of HN numskulls who just luuurb to chime in with a list of their "meds," for conditions imaginary and otherwise, whose idea of activity is playing video games while subsisting on a diet of microwave pizza rolls. Such people probably got that way in the first place by being coddled, rather than encouraged to not commit slow suicide by remaining inert lumps of dung who think their Jetsons fruit salad is doing them any good. Maybe being confronted with harsh language will save a few of them. Either way, it won't hurt them. But hey, that's just, like, my opinion man.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#163

Earlier quoted context omitted.

All cause mortality is absurdly higher if you use drugs to sleep, including OTC stuff[0]. So, probably not. Almost certainly same story with other "meds" that dipshits pop like popcorn[1]. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883191/ [1] https://www.nhs.uk/news/medication/widely-used-class-drugs-l...

> All cause mortality is absurdly higher if you use drugs to sleep, including OTC stuff[0]. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883191/ Your reference only studied people who took Z-drugs, benzodiazepines, or no medications, and says nothing about OTC sleep medications. There are no OTC Z-drugs or benzos on the market. The paper also notes that only chronic use of Z-drugs and benzos were associated with…

You didn't read the papers. Anyway, the literature is chock full of "sleeping pills associated with early death." Whether the pills are causing it, or because people with deadly sleep apneas pop a lot of pills is really pretty irrelevant: take home is the pills ain't helping you, so you better get serious about fixing things.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#164

I'm currently reading the book, "Why We Sleep (Unlocking the Power of Sleep and Dreams)" right now and I'm stunned by all the new things we ignored when it comes to sleep. There are so many fascinating aspects of our life and body, all governed by Sleep. I highly suggest reading the book to explore more about your sleep.

It's not a good book and was basically just used to get Matt Walker on daytime talk shows. It doesn't even attempt to answer the question in its title, and it has many cherry picked studies that don't actually prove what he's implying they do.

The book is great and Matt Walker is one of the leaders in the field of sleep study. There are numerous studies backing what he's written - even though there were some inaccuracies with some of the citations & ways he presented some facts, that is entirely expected in a book presenting thousands of such facts, and the author is planning on fixing all in the upcoming revised edition.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#165
post #105

Earlier quoted context omitted.

I wasn't diagnosed with this but I had the symptoms and the consequences you mentioned. It took a long time to fix. Here's some things I tried. Some may have helped or none may have helped. * I bought blackout blinds and use a sleeping mask (sometimes earplugs) * I bought a bright light ( https://www.amazon.co.uk/gp/product/B07FFJYMVS ) and a smart plug. 15 mins before I wanted to wake up I would have a timer turn on…

Reminds me of wozniaks advice: https://supermemo.guru/wiki/Curing_DSPS_and_insomnia

Bookmarked for reading later, I think I suffer from this. I normally can’t fall asleep before 2-4am, even if my body is physically tired I often feel like I can’t turn off my brain, once I’m asleep I sleep well and wake up naturally after 6-8 hours. It does seem cutting off screens an hour or so before bed and melatonin sometimes helps.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#166
post #133
post #105

Earlier quoted context omitted.

I wasn't diagnosed with this but I had the symptoms and the consequences you mentioned. It took a long time to fix. Here's some things I tried. Some may have helped or none may have helped. * I bought blackout blinds and use a sleeping mask (sometimes earplugs) * I bought a bright light ( https://www.amazon.co.uk/gp/product/B07FFJYMVS ) and a smart plug. 15 mins before I wanted to wake up I would have a timer turn on…

Have you tried melatonin? I had something similar to this and taking melatonin 1h before my desired bedtime has changed my life.

Does it make you drowsy in the morning? I typically take 7mg and it helps me fall asleep but I feel drowsy the next day.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#167
post #78

Earlier quoted context omitted.

"Dipshits" is an incredibly rude way to describe people who are most likely just ignorant.

I think people who stick heaps of fruit salad pills into their gob because "muh science" are, in fact, dipshits. Darwin award winning dipshits. Plenty of "merely ignorant" people have the common sense required to refrain from shoving grams of factory produced mystery chemicals down their throats because some marketer convinced them it might be a good idea. I realize there is a large contingent of HN numskulls who jus…

> I realize there is a large contingent of HN numskulls who just luuurb to chime in with a list of their "meds," for conditions imaginary and otherwise, whose idea of activity is playing video games while subsisting on a diet of microwave pizza rolls.

First thing I thought of was Ray Kurzweil.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#168
post #150

You should take these findings with a big grain of salt. Remember we don't yet even have a causal model of Alzheimer's and dementia. Amyloid plaques are strongly associated with Alzheimer's but it's not clear if they're the actual cause or if they're just a residual indicator that something else has already gone wrong in the brain. As a counterpoint to the amyloid hypothesis, we also see amyloid build ups in patients…

>big grain of salt Isn’t the point of the “grain of Salt” to indicate that it is trivial? If so, then by saying “big grain of salt” aren’t you undermining the point of the original statement? I see this regularly and wonder if I am missing something.

The phrase means the same as "be sceptical".

Vaccine contains microchips? Yeah you're going to want to take that with a major grain (pinch in the UK!) of salt / be highly sceptical about it.

https://thesaurus.plus/related/pinch_of_salt/scepticism

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#169

What does this mean for people with severe Delayed Phase Sleep Syndrome (DSPS)? I do not feel the need for sleep until usually about 2am, and I find it exceedingly difficult to wake up before 10am. And yes, it's made it extremely difficult to live a "normal" life like your typical person who can wake up at 7am without issue. It's been a problem with relationships, poor performance in school, issues in promotions and…

Well are you getting a full night's sleep? If so that seems fine. You can still get sufficient light exposure in the daytime to better anchor your circadian rhythm, and increased vitamin D3 intake helps to this end (in the day).

If you're intent on shifting your circadian rhythm backwards, you'd have to get up earlier in the morning at a consistent time and try to eschew what might delay your onset, i.e. blue light emitting electronics, before bed. You can use a blue light filter like flux for that in the evening to help. more on that here - https://insomniasos.net/

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#170
post #134
post #105

Earlier quoted context omitted.

I wasn't diagnosed with this but I had the symptoms and the consequences you mentioned. It took a long time to fix. Here's some things I tried. Some may have helped or none may have helped. * I bought blackout blinds and use a sleeping mask (sometimes earplugs) * I bought a bright light ( https://www.amazon.co.uk/gp/product/B07FFJYMVS ) and a smart plug. 15 mins before I wanted to wake up I would have a timer turn on…

You're probably right, but it's annoying we need to apply this perfect regime just to fall asleep. Why can't we just be tired in the evening? I have friends who would fall asleep on the couch while watching a movie if it went past 11pm. Meanwhile I have to do some bullshit ww2 pilot exercise just to fall asleep at 1am.

I think some of us genetically are more sensitive to the impact of light, caffeine, etc on the circadian rhythm. There's also other factors like work. Cortisol levels are higher coming off of work and it takes time to wind down.

Think of it this way: there's nothing special about a time zone, and yet we know that if we moved several time zones away, we'd shift. The differences are in light patterns, timing of work and social life, food intake, etc. Incidentally, many of these factors are within our control.

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