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Psilocybin Produced in Yeast

phys.org

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Re: Psilocybin Produced in Yeast

#161

Post by 0_____0 »

gwbas1c wrote: post #146
mikeg8 wrote: post #5

> "It's unfeasible and way too expensive to extract psilocybin from magic mushrooms and the best chemical synthesis methods require expensive and difficult to source starting substrates...” This is one of those situations where I feel like we (humans) are approaching it all wrong. Why over complicate it by trying to “extract” the psilocybin instead of treating it like marijuana and growing the mushrooms in highly con…

I like how mushrooms taste, but my sister doesn't. Her husband even insisted that we don't serve any mushrooms at their wedding. (Granted, it's been years since I last ate magic mushrooms. I loved the way they tasted, but I don't think it's fair for someone who doesn't like they way they taste to have to gag them down just for a trip. I can still remember how they tasted, and the wonderful visions I had.) Mushrooms a…

Store as dried fruits with a dessicant packet and a hand warmer (oxygen scavenger) in freezer. Half of the weird mushroom flavor/odor is from it being improperly dried and stored. I dry mine to cracker-dry, and you really don't get a lot of flavor or texture from them.

If they're still hard to consume, shred them and extract into tea. Psilocybin is water soluble. Some like to add lemon juice, as it supposedly hurries the conversion of psilocybin to active psilocin (not sure how true this is). Tastes a little different but is relatively quite palatable.

Re: Psilocybin Produced in Yeast

#162

Post by steve76 »

ralusek wrote: post #110
kfrzcode wrote: post #44

Consciousness studies will be the next frontier and may bring our race further, faster, than space exploration. In my opinion.

I've never once heard a bit of insight from a psychonaut that was particularly game-changing. We're all connected, consciousness is an illusion, societal structures are somewhat arbitrarily defined, etc. These are the existential thoughts of teenagers. Life is just energy, energy is just vibrations, everything is a fractal, etc, these are just the existential speculations of people making baseless claims. Consciousne…

I care greatly if people do whatever they'd like. Tolerances build up. Eventually the drug only stops withdrawals and people just take it just to be normal.

Money runs out, and the part of your body that has been numbed by drugs wakes up. That part rarely gets attention. Getting over it can take decades, not just some simple two month detox, and everyone else has to clean up the mess. It gets ugly quick.

That's why we have locks on our doors and traffic stops. I really wonder what the world would look like if people were nice.

> But giving people psychedelics and having them explore their own consciousnesses is not going to catalyze our society forward by leaps and bounds, that has been done since at least the 60s.

How about the reverse?

You tripping?

ok. Turn down the atom interferometer please.

Re: Psilocybin Produced in Yeast

#163

Post by ericmcer »

mikeg8 wrote: post #5

> "It's unfeasible and way too expensive to extract psilocybin from magic mushrooms and the best chemical synthesis methods require expensive and difficult to source starting substrates...” This is one of those situations where I feel like we (humans) are approaching it all wrong. Why over complicate it by trying to “extract” the psilocybin instead of treating it like marijuana and growing the mushrooms in highly con…

It does a little bit cut into the organic/spiritual nature of the experience. If I am going to get high I have recently gone back to just smoking weed instead of eating a 'watermelon burst' gummy or something. Smoking with a pipe is timeless and the ritual, smell, taste are all a part of it for me.

Same thing with mushrooms, preparing the tea for me is a part of the experience.

Re: Psilocybin Produced in Yeast

#164

Post by ericmcer »

colechristensen wrote: post #49
mikeg8 wrote: post #5

> "It's unfeasible and way too expensive to extract psilocybin from magic mushrooms and the best chemical synthesis methods require expensive and difficult to source starting substrates...” This is one of those situations where I feel like we (humans) are approaching it all wrong. Why over complicate it by trying to “extract” the psilocybin instead of treating it like marijuana and growing the mushrooms in highly con…

There are negative side effects from consuming the mushrooms which you don't get from purified psilocybin. Dosage is important. There isn't a way to test for potency which would ensure a reliable dose. Argument fallacies: * your anecdotal positive experiences * suggesting superiority because something is "from nature" * referring to "mistakes from the past" without naming any * suggesting superiority that "has been (…

Your argument is logical I guess, but we are not logical creatures and I prefer to make the choice to live in a more magical/spiritual world. Why wouldn't you? We end up in the dirt either way.

Re: Psilocybin Produced in Yeast

#165

Post by uxp100 »

andai wrote: post #117
rv-de wrote: post #105

Earlier quoted context omitted.

There are various ways to ingest mushrooms. Having said that - let me assure you, the problem is not just from the fibers it's very well the substance itself. One reason is the activation of serotonin receptors of which there are huge numbers in your gut.

Interesting. I think LSD works on Serotonin too? But it has much less body load in my experience (at least, the unpleasant kind I associate with psilocybin).

I have heard that LSD can cause stomach cramping with people who already are prone to stomach issues/IBS/etc. Not something I've personally experienced.

Re: Psilocybin Produced in Yeast

#166

Post by cuspycode »

taneq wrote: post #73
samatman wrote: post #32

Earlier quoted context omitted.

It does say that. It's wrong, what it says, but it definitely says it.

I'd love to hear more about this cheap, efficient extraction of psilocybin from mushrooms.

I'd love to hear someone actually quoting dollars per milligram, and do an actual cost-benefit comparison between the mushroom production pathway and this novel yeast pathway. You can produce mushroom juice in a H20 solution cheaply at home for about $0.1 per 10mg of psilocybin. If you want pure psilocybin, it needs to be extracted from such a solution, but I am sure some similar extraction is needed for yeast-produced psilocybin as well. Obtaining psilocybin from yeast sounds like a great technological breakthrough, but I'm highly skeptical of economic arguments where no actual numbers are presented.

Re: Psilocybin Produced in Yeast

#167

Post by Anoncomposed »

mikeg8 wrote: post #5

> "It's unfeasible and way too expensive to extract psilocybin from magic mushrooms and the best chemical synthesis methods require expensive and difficult to source starting substrates...” This is one of those situations where I feel like we (humans) are approaching it all wrong. Why over complicate it by trying to “extract” the psilocybin instead of treating it like marijuana and growing the mushrooms in highly con…

What is the going price for 1 mg of psilocybin? I am seeing a site sell magic mushrooms (Psilocybe Aztecorum) with a psilocybin quantity of ~1g for $15. 7 g for $72. Is this the publicly available norm or does it seem cheap.

Re: Psilocybin Produced in Yeast

#168

Post by vikramkr »

andrew_xor_andy wrote: post #39

> the best chemical synthesis methods require expensive and difficult to source starting substrates This type of thing always amazes me about nature -- obviously all the ingredients necessary exist in the soil the mushroom is grown in! Yet the best we can do to mimic nature is get some hard-to-acquire substrates. It's so interesting how, given enough time, the universe can produce a self-replicating organism that can…

The mail innovation to come out of 4 billion years of natural selection are essentially just really really really good catalysists: enzymes. They've got an admirable specificity and efficiency. We dont have 4 billion years to figure out how to do it as well, but we've gotten not that terrible in just a few thousand!

Re: Psilocybin Produced in Yeast

#169

Post by crusso »

Yeast is everywhere. I was recently reading about how to cultivate wild yeast in a jar left on your countertop for use in making sourdough bread.

What happens when some of the yeast you capture in the environment is producing psilocybin?

I saw no mention in the article of considerations to keep these genetic modifications contained within the psilocybin manufacturing process.

Re: Psilocybin Produced in Yeast

#170

Post by floatrock »

asdff wrote: post #26
mikeg8 wrote: post #5

> "It's unfeasible and way too expensive to extract psilocybin from magic mushrooms and the best chemical synthesis methods require expensive and difficult to source starting substrates...” This is one of those situations where I feel like we (humans) are approaching it all wrong. Why over complicate it by trying to “extract” the psilocybin instead of treating it like marijuana and growing the mushrooms in highly con…

Growing it in yeast would be great if you are trying to get a consistent quantity of the drug. You could do vats at a time all genetically identical and producing the same yield batch over batch, and can scale up and down your operation for as much as you have vats and yeast food. This is something you want if you are going to press this into pills at a certain dose and give to people for psychiatric disorders, not f…

Also if you want a consistent, reproducible dosage to do reasonable controlled medical-grade studies.
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