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Ibuprofen alters human testicular physiology

pnas.org

161–170 of 216 posts

Re: Ibuprofen alters human testicular physiology

#161

Earlier quoted context omitted.

It’s worth noting that a legal version, extracted from Hemp (a form of Cannabis that has no psychoactive properties), is available via mail order anywhere in the U.S.

I've wondered about the efficacy of the hemp versions. A friend of mine was using CBD oil to alleviate his daughter's seizures, and had told me that the hemp based ones were ineffective, and that THC in a small dose had a complementary effect. I'm not sure if that applies to everything CBD is good for, but does anyone know if it works mostly the same for body aches and the like?

I’ve tried both (for migraines) and didn’t notice much of a difference.

Re: Ibuprofen alters human testicular physiology

#162
post #135

Earlier quoted context omitted.

It’s worth noting that a legal version, extracted from Hemp (a form of Cannabis that has no psychoactive properties), is available via mail order anywhere in the U.S.

Hemp is not "a form of" cannabis. It IS cannabis.

Sorry...I should have said “variety” instead of “form.”

Re: Ibuprofen alters human testicular physiology

#163

Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?

aspirin might be bad for your teeth: http://jada.ada.org/article/S0002-8177(14)61356-8/fulltext

Re: Ibuprofen alters human testicular physiology

#164

Earlier quoted context omitted.

the low/no-thc high-cbd strains generally don’t do this.

It does screw up your sleep massively (basically REM sleep is gone)

it can, yes. i still dream at a microdose level.

Re: Ibuprofen alters human testicular physiology

#165

Earlier quoted context omitted.

> Any scientific study with less than 200 participants should be discarded ... Imagine you're investigating a drug for hair loss. You gather a group of 31 bald white men. 15 of them take a placebo and 16 take the experimental drug for 24 weeks. If, after 24 weeks, you find 1 of 15 controls with a full head of hair, and 14 of 16 test subjects with a full head of hair, is 31 too small a sample size?

Yes. Let me rephrase what you phrased: Imagine you're investigating a drug for hair loss, like 20000 other researchers hellbent on achieving their goals. You gather a group of 31 bald white men. 15 of them take a placebo and 16 take the experimental drug for 24 weeks, but because your random allocation put more extra bald people in your non-control group you fixed it by balancing the two groups. Your counterpart that…

You had to introduce a lot of assumptions to invalidate the n=31. So let me lay it out in more detail.

I recruited 31 white men who self-report having no hair on at least 500cm^2 of their head. They all had hair as adolescents, and lost it gradually throughout their 20s or early 30s. They're all at least 37 now.

I then sort them into the two groups by assigning sequential IDs in random order. Those with an odd ID are in Group A, those with an even ID are in Group B.

I then give each participant in both groups a placebo for 24 weeks, having them check in every 2 weeks to measure hair growth, if any. At 24 weeks, I randomly assign two new courses of treatment to each group. I do this blindly, giving Group A pill X and Group B pill Y. Another 24 weeks (with check-ins every 2 weeks) and I find that Group A (taking pill X) all have full heads of hair. Well, except for Paul and Maury.

Meanwhile, Tom, in Group B (who took pill Y), is the only member of his group to have a full head of hair.

Statistically-speaking, my n=31 was a great sample size, and I'm also pretty sure Tom discovered he had sugar pills and stole the real stuff from Paul or Maury. :)

To address the possibility of seeing these results due to a confounding variable (like above average testosterone), this is about as likely as shuffling a deck of 31 cards, and all the red ones ending up in the front and all the black ones in the back. About 0.0000003%

Re: Ibuprofen alters human testicular physiology

#166

Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?

I can’t take Ibuprofen (or any typical NSAIDS including aspirin) because of a medical condition, which has sucked over the last decade because acetaminophen really doesn’t help me at all when I’m excruciatingly sore for whatever reason. In Oregon and Washington, where I’ve lived for pretty much my entire life, legal marijuana has been amazingly helpful, at least since I finally got around to trying it. The various pr…

I think kratom is helping me. I experience no psychotropic side effects, which is great. At some point, I'll stop kratom for a few months, see how my pain mgmt handles it.

YMMV.

Re: Ibuprofen alters human testicular physiology

#170

Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?

I tend to use naproxen but something tells me that would kill me as well

Naproxen (and Ibuprofen) can both cause kidney damage, particularly when you are physically active and/or not hydrating well (where hydrating well means getting enough sodium and glucose in addition to water). After experiencing kidney pain after taking naproxen on a hike and learning about this possible side-effect I am now very careful about naproxen use.

http://www.gssiweb.org/en/sports-science-exchange/article/ss...

http://www.mdpi.com/1424-8247/3/4/1279/pdf

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