151–160 of 201 posts
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I really wish these weren’t forever drugs. I would be next in line.
GLP-1s aren’t “forever drugs.” They’re eliminated so fast from your system you need to keep taking them to keep the effect. That’s the opposite of a forever drug. If you go off them, you just return to the way you were.
I think there's a lot of just-world fallacy going around re: how I keep running across the following pattern online now that GLP-1RA drugs exist. Commenter A (esp. often a woman, though of any age): I lost a lot of weight and people treat me radically better. I did not change my behavior in a way that explains this; it seems like stigma / prejudice. Commenter B: I have never met you but it is probably the case that s…
I would point out that there's a middle way between those stances: GLP-1 receptor agonism has anti-auto-immune effects. (I don't know yet if anyone has determined whether this is a direct effect of GLP-1R agonism; or whether e.g. metabolic disorder has auto-immune aspects, and GLP-1R agonism effectively treats metabolic disorder; or whether it's just that e.g. sugar and other simple carbs are directly pro-auto-immune…
I find it extremely interesting that GLP-1 agonists and GLP-1 receptors are highly pulmonary.
(There seems to be a persistent correlation between detailed pulmonary mechanisms, biology, responses… and neuroinflammation. Which does make sense when we consider the metabolic demands of the brain, which can be highly localized and sensitive to fine variances in supporting system capacity.)
My from-the hip take – from the hip!, no judging pls; It's a hunch, working to falsify it – is that… everything that makes humans aggressive to someone. Every feature someone can present that increases the odds of aggression… is a heuristic for neuroinflammation.
It's a lot of things, but neuroinflammation is a pretty consistent good match as core heuristic.
As in: GLP-1 agonists do reduce neuroinflammation. And then the hunch: This generally and ubiquitously reduces the aggression-induced features thereof.
(This take is somewhere between riffing on concepts and a surprisingly earnest and mechanistic theoretical perspective. Started as jokey banter but it's kinda hard to unsee it. not sure where else to place it, haha.)
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Oh god… if only I could quit food, too.
No but like... why is it a concern? Money? The health problems that GLPs produce help people avoid are way more costly than the drugs will ever be. Especially now that the market is so competitive and will only get moreso.
Anything that’s “starting tomorrow and until the day you die” just seems like a thing I shouldn’t take lightly.
Also I’m not badly, badly overweight. So it’s not like “it’s this or cardiac arrest in a year or two”, for me. I should probably be dealing with my issues the old timey way.
The stakes look very different for other people, obviously.
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GLP-1s aren’t “forever drugs.” They’re eliminated so fast from your system you need to keep taking them to keep the effect. That’s the opposite of a forever drug. If you go off them, you just return to the way you were.
Which means if you want to maintain their effect, you need to keep taking them forever. So maybe GP used the wrong term but I suspect they meant exactly this. In any case, we just don't know what kind of long-term effects these drugs have. No one knows what happens if you come out of them 30 years after you started.
If looks are important for employment how then men find a job? Men are mostly unattractive even compared to not a perfect woman. In terms of looks and style, average man loses to an average woman. Or employers require only women to be attractive?
Well you kinda said it yourself? If men are generally unattractive then a man should be less likely to lose out to a better-looking man, simply because there's fewer of these to go around.
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Usually, chronically-overweight ppl have tried regulating weight with all kinds of diets, lifecycle interventions, regular exercise, etc, and a lot of the time the thing that actually worked was the GLP-1. I think this speaks a lot to the variance in metabolism, hunger, cravings etc across the population.
The rub is that if they did a good job with those things, they would have worked. Most people cannot accurately account for calories and poorly estimate how hard they are actually working out.
I think people often tend to treat drastic deviations from standard appearance as an indicator for undesirable character traits. If you are badly groomed as a man, you tend to be perceived as careless. In my experience if you are obese, people think you lack will power and discipline. Changing how people view you for the better always has an influence on your personal success.
first sentence is one step from outright discrimination even if not everyone recognizes it. if you’re visibly transgender/queer, have noticeable accent, visible disability, and on and on and on
In addition to this, I regularly am looking for contract work, and have jobs outright ask me if I am part of the LGBT community in the interview process. This is almost all coming from California. Before DOGE cut most of the budgets, NGOs would tell me that they would only hire me if I was part of a minority group.
Since there's no test, I just say that I am to get more work (and this has gotten me more work).
I've worked with LOTS of people from the LGBT community. At this point, discrimination just isn't happening for those groups at any mainstream level. Women also make up > 50% of management in almost all companies I deal with, so the 'glass ceiling' is also a myth.
I think there's a lot of just-world fallacy going around re: how I keep running across the following pattern online now that GLP-1RA drugs exist. Commenter A (esp. often a woman, though of any age): I lost a lot of weight and people treat me radically better. I did not change my behavior in a way that explains this; it seems like stigma / prejudice. Commenter B: I have never met you but it is probably the case that s…
Before she transitioned, as a man she said she'd get lots of compliments and kudos from customers for basically just doing her job at Subway. As a woman, though, people were much more likely to complain and she was rarely complimented, and only if she went "above and beyond" her normal work duties.
The thing I loved about this is that, like the women who lose a lot of weight, she basically "acted as her own control". When it's different men and women you can argue over whether or not people behaved differently, but it's harder to do that (or at least it should be) if it's the same person.
Earlier quoted context omitted.
GLP-1s aren’t “forever drugs.” They’re eliminated so fast from your system you need to keep taking them to keep the effect. That’s the opposite of a forever drug. If you go off them, you just return to the way you were.
I think they mean they're drugs you have to keep taking forever (for the rest of your life) to keep the effects.
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Those fat cells will be screaming for fat when empty. GLP-1s are a drug for life currently, we aren't treating them as such but we should because there is no avoiding the need to continue to quiet those fat cells down from their errant signalling to the brain.
you described the need to switch to healthy diet and exercise routine to maintain weight after finishing treatment..