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Sleep research led to a new sleep apnea drug

temertymedicine.utoronto.ca

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Re: Sleep research led to a new sleep apnea drug

#151

Post by patrickdavey »

petesergeant wrote: post #82
patrickdavey wrote: post #23

Earlier quoted context omitted.

I've tried a CPAP machine for 6 weeks and felt no different and gave up. I think I was a 6 on the scale. I wish it had worked though! Currently I've just given up and embracing feeling relatively tired all the time. I've tried side sleeping devices (woody knows backpack) mandibular advancement splints etc. So hard to tell (I find anyway) to get to a definitive answer

Three more things to try if you haven’t, on a “can’t hurt” basis: nightly Avamys spray (might need a scrip depending on where you are), magnesium glycinate before bed, little bits of plastic that go inside the nostril and hold them open.

Yip interesting, you're the second person in a week who has suggested the magnesium. I frankly never trust these suggestions of supplements (having tried some before), but, https://pmc.ncbi.nlm.nih.gov/articles/PMC12412596/ at least suggested it was a modest improvement. I'm going to give it a try at least.

Re: Sleep research led to a new sleep apnea drug

#152

Post by array_key_first »

procone wrote: post #49
an0malous wrote: post #29

I went through the whole process of seeing an ENT, using the machine for the at-home sleep study so insurance would give me a CPAP, then not being able to sleep with a CPAP, and over the course of a couple years I fixed my sleep apnea by fixing my posture and breathing. If you have forward head posture or are not used to breathing through your nose, you might also benefit from this. I think it’s kind of crazy that we…

What a ridiculous post. Please leave the Reddit pseudoscience at the door. There are researchers actively working and studying people with sleep apnea. They're not suffering from "forward head posture" or "breathing wrong". I have severe sleep apnea and no amount of "breathing exercises" are going to cause my soft palate to uncollapse itself while I'm trying to get REM sleep.

I mean naturally the question is why do some people's soft palate collapse while sleeping while others don't.

Could it possible be due to musculature and structure of the palate and tongue? And, if it is, could therapy help mitigate it?

I mean, just consider the conditions physical therapy can help with today. Is it really so out of the question that physical therapy could help obstructive sleep apnea?

Re: Sleep research led to a new sleep apnea drug

#153

Post by y-curious »

gushogg-blake wrote: post #132
y-curious wrote: post #83

Earlier quoted context omitted.

I’m always on HN talking about myofunctional therapy (my mom is a practitioner in NYC). Recommend looking into it in addition to losing weight as treatment.

Currently doing myo, and Buteyko! Glad to see someone else here. I've also done a MARPE.

Great! I hope you have good results. It’s hard work to keep consistent with the large amount of exercises but the results are really impressive for those that stick with it.

Re: Sleep research led to a new sleep apnea drug

#154

Post by folkrav »

LooseMarmoset wrote: post #31
folkrav wrote: post #24

Earlier quoted context omitted.

Oof, and here I thought my AHI of 69 was bad (which it kind of is regardless). My condolences. Glad the CPAP helped, it completely and utterly changed my life too.

256 here :( the cpap is a wonder, I can't sleep without it. I only wish I'd gotten one 10 years sooner. I have whole years of my life missing from my memory - REM sleep is very important to long-term memory formation. Using my CPAP now nets me about 1.5 AHI. if your doctor tells you to get one, get one.

Ouch! I'm under 3. It follows me everywhere too. Early on, I kept trying leave without it when sleeping out for one night. All it achieved was having to catch up on sleep for the next few days. Nowadays I use it even when taking a short nap.

Re: Sleep research led to a new sleep apnea drug

#155

Post by tedk-42 »

procone wrote: post #125
tedk-42 wrote: post #97

Earlier quoted context omitted.

Wow you sound very defensive. If it's not obvious I meant breathing while sleeping at night in a sleep apnea discussion, I think you need to analyse your own internal bias and possible self-hate. I'm very sure i have sleep apnea now as i wake up literally in panic where i'm not breathing + have a full bladder and need to go a few times a night (which i've read as a kidney response with sleep apnea). As i said this al…

Gross.

Wow what a trash discussion this was.

Turns out it was you who are polluting this community with low IQ takes.

Re: Sleep research led to a new sleep apnea drug

#156

Post by gdudeman »

georgemcbay wrote: post #14

Surprisingly the most effective treatment I've found for my own apnea is just wearing an inexpensive soft cervical collar to sleep, but there are lots of different things that can contribute to sleep apnea, so YMMV. After dealing with unexplained ectopic heartbeats (sometimes PVCs, sometimes PACs) I saw a chain of doctors and that included both getting a sleep study done and seeing a cardiologist. I was diagnosed wit…

Curious how you tested this - did you do repeated home tests to figure this out?

Re: Sleep research led to a new sleep apnea drug

#157

Post by georgemcbay »

gdudeman wrote: post #156
georgemcbay wrote: post #14

Surprisingly the most effective treatment I've found for my own apnea is just wearing an inexpensive soft cervical collar to sleep, but there are lots of different things that can contribute to sleep apnea, so YMMV. After dealing with unexplained ectopic heartbeats (sometimes PVCs, sometimes PACs) I saw a chain of doctors and that included both getting a sleep study done and seeing a cardiologist. I was diagnosed wit…

Curious how you tested this - did you do repeated home tests to figure this out?

Most CPAP machines including the one I have record a lot of data that can be analyzed via software like OSCAR:

https://www.sleepfiles.com/OSCAR/

On the machine I have (ResMed AirSense 10) the data gets written to an SD card I can pull out and import into OSCAR to see what the machine detected about my sleep apnea events.

I also (not always, but when I'm testing changes) use a continuous pulse oximeter to test my SpO2 blood oxygen % over the entire night. The data from this can either be combined with the data from the CPAP machine, or used on its own to test things like how I do with the collar and no CPAP machine, since the SpO2 drops are the dangerous thing I'm trying to avoid by eliminating the apnea events.

I use the Wellue SleepU for SpO2 monitoring but there are a lot of similar devices (the kind with finger tip sensors are generally more accurate than the wristwatch based solutions).

Re: Sleep research led to a new sleep apnea drug

#158

Post by petesergeant »

patrickdavey wrote: post #151
petesergeant wrote: post #82

Earlier quoted context omitted.

Three more things to try if you haven’t, on a “can’t hurt” basis: nightly Avamys spray (might need a scrip depending on where you are), magnesium glycinate before bed, little bits of plastic that go inside the nostril and hold them open.

Yip interesting, you're the second person in a week who has suggested the magnesium. I frankly never trust these suggestions of supplements (having tried some before), but, https://pmc.ncbi.nlm.nih.gov/articles/PMC12412596/ at least suggested it was a modest improvement. I'm going to give it a try at least.

Great, good luck! Avamys is real medicine (fluticasone furoate) and also worth a look in if you think part of the issue might be breathing.

Re: Sleep research led to a new sleep apnea drug

#159

Post by shermantanktop »

dgellow wrote: post #137
shermantanktop wrote: post #136

Earlier quoted context omitted.

Mine is not noisy! It requires minor weekly cleaning, not a big deal. The bigger problem is habituation to the mask/hose setup. If you sleep on your back you’ll have it easy. Side and stomach sleepers or people who turn a lot will have a harder time getting used to it.

What model do you have?

Resmed AirSense11. Yes it has a gsm modem and transmits my breathing patterns to the cloud.
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