Over the years, I (and I imagine many others) switched over to WASD to play newer games with mouse + keyboard, but this meant using the left hand for "arrow keys"
Now I can directly compare how proficient I am with WASD vs Arrow Keys and the result surprised me. I was way worse with arrow keys (right hand) even though back when WASD was becoming a thing I'd rebind WASD to arrow keys because it felt too weird! I would've never imagined back then that WASD could ever feel as natural as arrow keys.
Makes me wonder how much of handedness is truly innate vs learned.