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Peptides: where to begin?

science.org

151–160 of 431 posts

Re: Peptides: where to begin?

#151

Peptides are a revolution and you don't need to know how they work to know that they work (for various people for various conditions). There is a tension between empiricism and fundamentalism with much of medical science focusing on fundamentalism. Now with the ability to collect and search large amounts of empirical data and communicate it peer-to-peer people are picking up on a lot of things that work without knowi…

  > Peptides are a revolution and you don't need to know how they work to know that they work
Perhaps. But knowing the mechanism of how they work sure seems fundamental to ensuring that they are safe to use.

Re: Peptides: where to begin?

#152
post #79

Earlier quoted context omitted.

I imagine it's legally risky to buy a large quantity, test it, and then resell smaller quantities. That's a shame because the alternative is probably that some folks settle for products of dubious quality and end up getting hurt.

Actually, you just described most of the tele-health and compounding pharmacies that carry GLP1s! Where do you think Hims, Ro, Brello, or the rest get the APIs they sell to their customers? They get them from grey market suppliers in China. They don't go to Ely Lilly or NovoNordisk and say, "politely sir, may I skirt around your IP and sell your drugs for 10x what they cost instead of 10,000x what they cost?" Hopeful…

This actually isn't true. Hims compounded the GLP1s themselves. They broke/are breaking the law. Theres lawsuits.

Re: Peptides: where to begin?

#153
post #24
post #15

> My patient is refusing a drug studied in 170,000 people because of side effects that a 124,000-person analysis just confirmed do not exist — while injecting a compound studied in 14 humans, from unregulated sources, based on the recommendation of someone who profits from selling it. She’s probably not the only one. And those using it believe they are “doing their own research.” Ok, and? At worst you waste a couple…

> I know dozens of people at my gym I don't think I even know dozens of people, full stop, let alone well enough to talk to them about their peptide use.

He's the guy that's selling them peptides.

Re: Peptides: where to begin?

#154

Peptides are a revolution and you don't need to know how they work to know that they work (for various people for various conditions). There is a tension between empiricism and fundamentalism with much of medical science focusing on fundamentalism. Now with the ability to collect and search large amounts of empirical data and communicate it peer-to-peer people are picking up on a lot of things that work without knowi…

I'm pretty sure there is no diagnostic test for ME/CFS. What are you referring to? Also I don't understand how semaglutide did help you while you're at the same time part of a minority risk group with a hypersensitivity to it. Isn't that a contradiction?

https://link.springer.com/article/10.1186/s12967-025-07203-w

Re: Peptides: where to begin?

#155
post #133
post #85

Earlier quoted context omitted.

That's because you grew up in a society still deeply coded to puritan moral viewpoints. People for so upset that GLP-1 has no long term side effects. There's still the crowd completely sure everyone will get HyperCancer in 10 years or something (they won't).

I'm glad we have GLP-1, and I don't think there are really major side effects. But they are ineffective outside clinical trial setting for treating obesity. It seems to be like treating alcoholism with disulfiram: it's a miracle in clinical trials but in the real world the patients just lower the doses or discontinue treatment after 1-2 years and go back to their old habits.

It is not ineffective outside of clinical trials. All the evidence says that people gain some weight back after they discontinue treatment - which is not a lack of efficacy. But they also usually gain back less then they lost.

https://pmc.ncbi.nlm.nih.gov/articles/PMC12361690/

Re: Peptides: where to begin?

#156

Peptides are a revolution and you don't need to know how they work to know that they work (for various people for various conditions). There is a tension between empiricism and fundamentalism with much of medical science focusing on fundamentalism. Now with the ability to collect and search large amounts of empirical data and communicate it peer-to-peer people are picking up on a lot of things that work without knowi…

> chase after whatever works

Crack is really moreish.

Re: Peptides: where to begin?

#157
post #8

Earlier quoted context omitted.

When medicine ignores nutrition entirely, and nutrient supplements are still complete unknowns, you have to wonder who the FDA is working for.

Medicine doesn't really ignore nutrition, but the problem is: 1. Most people don't believe it anyway. People want to hear they can eat hamburgers and milkshakes and be healthy. Telling them "we know that gives you heart disease and cancer" does nothing. 2. Nutrition is complicated and different for every person, because everyone has different things they can tolerate. The "perfect" diet is actually worthless because…

[deleted]

Re: Peptides: where to begin?

#158
> For a chemist, “peptide” has a pretty clear definition: any relatively short chain of amino acids, and when they get longer we go ahead and call them “proteins”, although the dividing line is a matter of personal opinion.

So, it is not just chemist but molecular biologist too. And the above is also not entirely correct. Yes, the author refers to size as threshold, before something is called a "protein". But the term protein has additional meanings that a peptide does not automatically have. For instance, a protein typically has a specific 3D conformation. It may be "sticky" after degradation or unfolding, but for the most part a protein is something with a 3D structure. A peptide does not necessarily imply the same. A protein may also have several polypeptide chains - insulin is a simple example for that: https://en.wikipedia.org/wiki/Insulin#Structure (A and B chain)

> So the number of different possible peptides is just ridiculously huge.

That's no surprise either - that's due to the code used. You add to the code, so of course length plays a role, as does the variety. There is a DNA->aminoacid mapping. The first has four possibilities per slot; the latter 20 (or more if you include e. g. selenocystein or pyrrolysine; and you have various post-translational modifications too, so you have more variety per slot).

> For comparison, it has been about ten trillion seconds since Homo sapiens emerged as a separate species.

The whole species concept is IMO outdated. It was created before people knew that DNA codes for the complexity in pretty much any species (excluding RNA viruses but they have reverse transcriptase, at the least some viruses, so ultimately RNA->DNA).

> The other one (by Sarah Hood) relates all this to RFJ Jr.’s advocacy. The flip side of “the government shouldn’t be able to force me to vaccinate my kids” is “I should have the right to take whatever medicines I want to without the government getting in my way”.

I don't see why that would be questionable. Would people do as Trump tells them to do? I would not. If you see Trump as a lobbyist, how many private interests may his government have? If they have a commercial interest then their statements may be biased.

> You don’t have an LC/MS or an NMR machine in your garage, so you can’t be sure what it is you’re really injecting

Right, so the whole system depends on trust. This is already a problem because you have to trust not only the government but ALL who were involved in scientific publishing. There were lies told in science too: https://en.wikipedia.org/wiki/Retraction_in_academic_publish...

Re: Peptides: where to begin?

#159

Earlier quoted context omitted.

If only there were a federal administration whose responsibility it was to collect data about food and drugs so we could rely on something more than anecdotes from random strangers on the Internet.

Do you have a link to those data showing GLP-1 agonists are ineffective?

I emphasize it's like the drug disulfiram: Very effective as long as patients take the full dose, but the lack of real-world efficacy stems from the difficulty in adhering to the treatment.

This study found that 84.4% non-diabetic patients stop taking GLP-1 drugs within two years. https://jamanetwork.com/journals/jamanetworkopen/fullarticle...

Re: Peptides: where to begin?

#160
post #17
post #15

> My patient is refusing a drug studied in 170,000 people because of side effects that a 124,000-person analysis just confirmed do not exist — while injecting a compound studied in 14 humans, from unregulated sources, based on the recommendation of someone who profits from selling it. She’s probably not the only one. And those using it believe they are “doing their own research.” Ok, and? At worst you waste a couple…

You know dozens of people from a single place that have chronic tendon/joint issues?

Sure. He says that they commonly use steroids. It's no wonder they have degenerative joint disease.
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