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Paracetamol disrupts early embryogenesis by cell cycle inhibition

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Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#151

Post by nikolay »

efnx wrote: post #126
nikolay wrote: post #116

I never took Tylenol/Paracetamol/acetaminophen, or anything containing it or given it to my children. We never reduce fever below 39.5/103.1 either - risks of febrile seizures are overstated and if you're a responsible parent, not a lazy one, you can see if things are going South, but there are other traditional means to lower fever. People are just too spoiled nowadays! I tested positive with COVID-19 on Tuesday and…

I’m not a doctor but I’m pretty sure ibuprofen is _not_ acetaminophen.

Of course it's not - I clearly said I never take acetaminophen, if for headache/fever I would rather take ibuprofen instead... but I don't take even that w/o a solid reason!

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#152

Post by nikolay »

tralarpa wrote: post #135
nikolay wrote: post #116

I never took Tylenol/Paracetamol/acetaminophen, or anything containing it or given it to my children. We never reduce fever below 39.5/103.1 either - risks of febrile seizures are overstated and if you're a responsible parent, not a lazy one, you can see if things are going South, but there are other traditional means to lower fever. People are just too spoiled nowadays! I tested positive with COVID-19 on Tuesday and…

I have not found any study published after 2020 (the year when the French minister made the statement) that advises against ibuprofen for COVID-19. But I'm not a doctor, so I'd be interested to know your source.

Studies showed negative efficacy. At best, no difference. [0]

[0]: https://c19early.org/ib

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#153

Post by Scubabear68 »

cfu28 wrote: post #143
tecleandor wrote: post #132

Earlier quoted context omitted.

If I ever had to say anything about Paracetamol, it would be: Remember: Paracetamol is hepatotoxic, very strong for your liver. Never take it if you have been drinking alcohol or have a weak/damaged liver. Paracetamol is the worst thing you can have for hungover: it might reduce your headache but will hurt a liver that it's already under pressure by the alcohol you drank last night. In moderation, as prescribed, shou…

While true, this is slightly overblown. I work at a liver transplant center where we treat patients with end stage liver disease and Tylenol is often the safest choice given these patients comorbidities. Granted, they’re getting their liver labs checked 1-2 times a day and are under close supervision but < 2g acetaminophen a day is considered fine. [I am not your doctor this is not medical advice]

My cousin worked in a toxicology lab in a hospital.

Way back in the 80s he was commenting on how understudied and under published Acetaminophen toxicity was.

In particular, taking Tylenol for hangovers was (and still is) a common but very dangerous practice.

As others have said, it is crazy easy to overdose on the stuff and suffer liver damage.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#154

Post by nikolay »

littlestymaar wrote: post #124
nikolay wrote: post #116

I never took Tylenol/Paracetamol/acetaminophen, or anything containing it or given it to my children. We never reduce fever below 39.5/103.1 either - risks of febrile seizures are overstated and if you're a responsible parent, not a lazy one, you can see if things are going South, but there are other traditional means to lower fever. People are just too spoiled nowadays! I tested positive with COVID-19 on Tuesday and…

> risks of febrile seizures are overstated and if you're a responsible parent, not a lazy one, you can see if things are going South Not always. Blaming “lazy” and irresponsible parents is disgusting.

But it's the truth. Something that has just a 2% incidence should not dictate 98% of the treatments. Compromising the innate immunity of the 98% is more disgusting!

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#155

Post by AngryData »

latchkey wrote: post #3

> "Smoking and alcohol are established risk factors for spontaneous abortion, underscoring the importance of the chemical environment during embryonic development." Both of my parents are/were heavy smokers drinkers from their teenage years. Mom died of lung cancer from smoking. Kind of wild to think that the odds were really stacked against my birth.

Smoking certainly isn't good, but it also isn't some super-poison like some people like to pretend. Nearly half of US smoked in the 40s and 50s and they had no problem having tons of kids.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#156

Post by aeonik »

losvedir wrote: post #150
stanford_labrat wrote: post #128

Earlier quoted context omitted.

Painkillers like ibuprofen are NSAIDs which inhibit the enzyme COX1/2, reducing prostaglandin production. Prostaglandins are an inflammatory hormone that do a variety of things, but specifically PGE2 plays a role in muscle stem cell activation to divide and produce more muscle fibers. The effect is probably realistically small, but you will leave gains on the table by taking ibuprofen after hard workouts.

Are you saying that lifting weights makes more muscle fibers? I was under the impression it does not, that it simply makes your existing muscle fibers bigger and stronger.

The main muscle fiber cells don't divide (usually), but satellite cells reproduce. Those fuse with the fibers though.

Though the science is not completely established here and there are some exceptions (obvious ones like cancer, etc...)

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#157

Post by latchkey »

AngryData wrote: post #155
latchkey wrote: post #3

> "Smoking and alcohol are established risk factors for spontaneous abortion, underscoring the importance of the chemical environment during embryonic development." Both of my parents are/were heavy smokers drinkers from their teenage years. Mom died of lung cancer from smoking. Kind of wild to think that the odds were really stacked against my birth.

Smoking certainly isn't good, but it also isn't some super-poison like some people like to pretend. Nearly half of US smoked in the 40s and 50s and they had no problem having tons of kids.

> but it also isn't some super-poison like some people like to pretend

My mom's dead from lung cancer, and my dad is basically on palliative care. He's a barely walking billboard for "smoking is bad for you".

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#158

Post by akk0 »

crmd wrote: post #108
more_corn wrote: post #33

Earlier quoted context omitted.

[flagged]

I had kidney stone surgery (laser lithotripsy) in Manhattan last Friday morning and literally the first thing I was given after changing into the paper gown was 2 500mg Tylenol pills and a cup of water. I don’t know if you’re a physician but the medical staff in manhattan tend to be at the top of their game, and they are cool with Tylenol.

Being safe acutely after surgery does not necessarily translate into being healthy over decades when habitually used as a hangover cure.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#159

Post by akk0 »

mullingitover wrote: post #110
Terr_ wrote: post #18

I've always had an (unreasonable?) dislike of Paracetamol/Tylenol ever since I found out it was the #1 cause of acute liver failure in the US. Liver failure is scary. https://en.wikipedia.org/wiki/Paracetamol_poisoning

The UK started requiring that Tylenol always be sold in blister packs instead of convenient-to-kill-yourself-with whole bottles of pills. Results: "Suicidal deaths from paracetamol and salicylates were reduced by 22% (95% confidence interval 11% to 32%) in the year after the change in legislation on 16 September 1998, and this reduction persisted in the next two years. Liver unit admissions and liver transplants for…

I am familiar enough with the numbers that I am not necessarily surprised, but I still find it emotionally hard to grok that more than one in five would-be paracetamol suicide victims would be dissuaded by having to pop the pills out of a blister pack first.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#160

Post by hdgvhicv »

a3w wrote: post #42
Terr_ wrote: post #18

I've always had an (unreasonable?) dislike of Paracetamol/Tylenol ever since I found out it was the #1 cause of acute liver failure in the US. Liver failure is scary. https://en.wikipedia.org/wiki/Paracetamol_poisoning

Most, if not all, medication would carry a poisonous symbol, if it were not taken out of regulation for that. Mostly, you kill organs by any overdose. Roughly: - Paracetamol overdose can cause severe liver damage and may be fatal. - Ibuprofen in high doses can lead to kidney injury and stomach bleeding. - Aspirin overdose may result in salicylate poisoning, causing ringing in the ears, confusion, and metabolic acidos…

You can overdose on water and oxygen too. What’s your point?
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