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GLP-1 drugs: An economic disruptor? (2024)

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Re: GLP-1 drugs: An economic disruptor? (2024)

#151

Post by timewizard »

casey2 wrote: post #103
timewizard wrote: post #68

> alcohol spending fell 85% You've replaced one drug with another. Freud would be proud. > If you told someone in 1850 that air conditioning would reshape the global economy, they'd think you were crazy. This is incredibly misinformed. You've lived /with/ refrigeration and /without/ malaria for so long you have no Earthly idea how people in the opposite state lived their lives or saw the world around them. > We're di…

I can't understand this type of thinking. "you replaced this drug with hundreds of known downsides with one that has none" Nice nonargument for the rest of your post. It's somehow misinformed to state the fact that the southern manufacturing industry simply cannot exist before air conditioning Frankly your attitude is evil and you are a proponent of evil.

> with one that has none

I can't understand this type of thinking. Of course it has downsides. You are being extremely disingenuous to say this. Let alone not acknowledging that different people experience different side effects. Plus you're completely ignoring the /reasons/ why people drink in the first place and abandoning any effort to impact those. Do you work for the company producing this drug or are you genuinely this gullible?

> your attitude is evil and you are a proponent of evil.

So you label things you don't understand as evil? What is this meant to accomplish?

If you really believe what you say then why aren't you pressing for the drug to be free? For free consultations to be given out? If it's truly this magical then it's very irresponsible to let a for profit company own it, sell it, and market it. Isn't it? Wouldn't that actually be evil? To champion this cause merely to make money for a patent holder?

You diminish these terms in your careless use of them.

Re: GLP-1 drugs: An economic disruptor? (2024)

#152

Post by _diyar »

dist-epoch wrote: post #117
Animats wrote: post #105

Wow. And this is the first generation of this class of drugs. Better drugs with fewer side effects are in the pipeline.

Maybe, or maybe not. Drugs are not like a smartphone. There is no reason to believe you can improve on them (except on price)

I see your point. But consider that drug generations are generally not defined by the manufacturer, but by the broad community of researchers and clinicians finding step-changes in their effectiveness/side-effect tradeoffs.

So by definition, if they ever consider a "new generation" of GLP1-agonists, they will be better by definition.

Re: GLP-1 drugs: An economic disruptor? (2024)

#153

Post by ForTheKidz »

_diyar wrote: post #136
ForTheKidz wrote: post #113

Earlier quoted context omitted.

> That late night trip to McDonalds will have you feeling like shit the next day I've never had this reaction to fast food before. I only eat mcdonalds every few months and yea it's not the highest quality food, but I don't think there's anything in it to make you sick any more than other burger places have. I imagine you'd have to have restricted fast-food nutrition for quite some time before you feel a difference.…

The way I read it, i think the original commenter would usually agree with you, but the effect of the drug turns the post-fast food / treat satiation from joy to pain.

I believe you're correct. Apologies for the confusion.

Re: GLP-1 drugs: An economic disruptor? (2024)

#154

Post by gcanyon »

cj wrote: post #74
devmor wrote: post #34

Earlier quoted context omitted.

> Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to forget to eat. This is the largest of several reasons I hesitate to try it for myself. I am a very big guy (I would be about 184lbs if I had 0% bodyfat at my current musculature level). From the experiences I hear, I would not only struggle to have enough energy to…

I’ve been hyper aware of the muscle loss caveats and I think it’s the most important thing to know when starting the drug. You really need to prioritize protein intake and make sure your calorie deficit isn’t extreme. Losing too much weight too quickly, with or without the help of a drug, can be very unhealthy. I drink 4 protein shakes a day (160g total) in addition to regular food. If it weren’t for the protein shak…

> Losing too much weight too quickly, with or without the help of a drug, can be very unhealthy.

Is there evidence to back this up? It sounds reasonable, especially without a limit on "too quickly" but (anecdata incoming) I'm curious because:

   - When I first tried a low-carb diet (for non-weight reasons) I lost about thirty pounds in under three months without really trying, and hit something like 12% bodyfat
   - When I started intermittent fasting (mostly unrelated to weight) I again lost about thirty pounds, this time in a little over three months, and probably ended up around 15% bodyfat
   - Since then I found that neither low-carb nor intermittent fasting had a significant effect on my weight, so:
   - When my doctor suggested I lose some weight I pretty forcibly calorie restricted, and lost about thirty pounds over four months (only down to about 20-something % that time)
   - And just recently, for cholesterol, I've done it again and lost 25 pounds so far in something under three months.
...and as far as I know I haven't suffered any ill effects. I have a concept 2 rowing machine, and I just rowed my slowest 10K ever :-/ but I did row a 10K, and I am in significant calorie deficit, and I probably have lost a fair bit of muscle along with fat, and I have been away from the rower for several months, so all up ¯\_(ツ)_/¯

All of which to ask, what evidence do you have, and what's "too quickly"?

Re: GLP-1 drugs: An economic disruptor? (2024)

#155

Post by dghlsakjg »

ctrlp wrote: post #135
cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

I've heard similar accounts and it sounds pretty wild. I'm not overweight and don't take anything but I do enjoy food. It would be horrible to me to lose the enjoyment of such a primal pleasure. If the choice is between being overweight and giving up the pleasure of eating altogether, I can imagine plenty of gourmands who would rather carry the extra weight for the physical and social pleasures of food. I've heard an…

Counter-anecdote.

I have not lost my appreciation for good food, I just eat less of it. I used to be unable to leave any food on my plate regardless of how good or bad it was, now I’m perfectly happy to leave something uneaten if it isn’t to my taste.

Re: GLP-1 drugs: An economic disruptor? (2024)

#156

Post by sfpotter »

lurk2 wrote: post #149

It's an interesting idea, but ultimately being sensationalized. The article starts off by making a compelling case that the widespread adoption of these impulse-control drugs will disrupt the economy and lead to many changes in business models built around impulse buys. The issue is that these drugs only entered the public consciousness within the last two years, and many of the business model changes that the author…

??? They're going to be trying to get on a weight loss drug, not an "impulse control drug". And I don't see why you would assume there's little overlap between people who desperately want to lose weight and people who drive drunk.

Re: GLP-1 drugs: An economic disruptor? (2024)

#157

Post by gcanyon »

Earw0rm wrote: post #88

The article posits that 80% of the top income quintile will be on this medication. I have to ask, why? (I'm not in the US, I should add). Like, sure, is the average American overweight? Yes. Are 80% of the top 20% of earners? Seems pretty doubtful, plenty of the rich look to be in reasonable shape. That statistic suggests that 80% of successful people have such poor impulse control that they end up seriously overweig…

> Admittedly if there were a GLP1 for procrastination, I'd be on that stuff like a shot...

Me too! Maybe later...

Re: GLP-1 drugs: An economic disruptor? (2024)

#158

Post by blackeyeblitzar »

cj wrote: post #61
willis936 wrote: post #49

Earlier quoted context omitted.

Yes, up to 15 mg. Maintenance levels at 5, 10, and 15. If you cannot tolerate a maintenance level you can still get it, but insurance will not cover it ($1000/mo rather than $15/mo.) This is not an unreasonable situation. https://www.goodrx.com/zepbound/dosage

Luckily during the “shortage” you can currently get GLP-1’s in vials rather than injection pens. The brand name GLP’s you can’t control the dose. But when you get it in a vial from a compounding pharmacy you can inject however much or little you want. Not looking forward to ever using the brand name version specifically for this reason

Aren’t any states like California trying to ban compounding pharmacies? It’s an unfortunate attack on individual freedom, but I am not sure if we will still have them 20 years from now.

Re: GLP-1 drugs: An economic disruptor? (2024)

#159

Post by adammarples »

casey2 wrote: post #84
agnishom wrote: post #33

The author is assuming that everyone will proactively start taking this drug. But I don't understand why? If Jerry is not obese, why would Jerry randomly start taking an anti-obesity drug?

It's not an "anti-obesity drug" it's a "set your hunger level to whatever you want drug" If Jerry is a body builder he can get to whatever body fat % he wants. If Jerry wants to save money or doesn't want to wake up early hungry he can do that too. If Jerry has religious beliefs about impulses coming from shaitan, he can get rid of them. Besides, 75% of Americans are overweight/obese that's pretty much everyone.

The number one group of people who will never ever want a powerful appetite suppressant are body builders. Lifting weights isn't hard, eating 6 meals a day is and they don't need to make it ten times harder for no reason.

Re: GLP-1 drugs: An economic disruptor? (2024)

#160

Post by dghlsakjg »

SoftTalker wrote: post #132
dghlsakjg wrote: post #120

Earlier quoted context omitted.

Maybe they are in Canada. Name brand Ozempic is $230 CAD or $160 from Costco up here

[flagged]

What a take.

I have no idea what Americans overpaying for healthcare has to do with a Danish drug company participating in the Canadian Healthcare market.

I’d rather thank the Canadian government for having a drug pricing review process.

If these companies don’t want to sell their drugs here, no one is making them. They are still here, so I think it’s safe to assume that they are still making money.

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