Seems pretty obvious to me. Humans didn't have factories until a couple hundred years ago. This means we are not adapted to factory made food. This entire debate is hilariously overcomplicated by smarty pants "show me the study" or "aren't cooked carrots processed?" types. 40-60% of nutritional studies cannot be replicated. It's called the "replication crisis". Google it. Rules of thumb are greatly underrated on HN.…
https://en.wikipedia.org/wiki/Appeal_to_nature
I remember a movie from the 1950s, where a character was arguing that "margarine is just like butter", and the response was that "butter needs no explanation".