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Psilocybin desynchronizes the human brain

nature.com

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Re: Psilocybin desynchronizes the human brain

#151

Post by _rs »

brotchie wrote: post #104
loa_in_ wrote: post #84

Earlier quoted context omitted.

Mushrooms are very contradictory in their nature to the modern "cog in the machine" lifestyle. It's a bit like being subjected to a software fuzzer. I imagine if learning from one's inputs, one will be afterwards less sure of concepts one was very sure about, but also less sure about concepts thought previously to be impossible. That will surely increase cognitive load, especially when one's life is pretty straightfo…

Agreed. Before a controlled high dose Psilocybin experience I "felt" my emotions: Anger, Fear, Frustration. Afterwards, I gained the ability to observe and "catch" my emotions in-flight. Not sure if it was neuroplasticity induced by the substance, or "you don't know what your brain can do until you know it". I liken it to previously having Ring 1 access to my thoughts, now I have Ring 0 access. Definitely persistent:…

Do you mean you can catch them and stop them? Or catch them and say "oh I'm starting to feel angry" without letting the anger consume you, but still let it exist. I'd love any elaboration you can share on this

Re: Psilocybin desynchronizes the human brain

#152

Post by newzisforsukas »

radlad wrote: post #115
psunavy03 wrote: post #112

Earlier quoted context omitted.

Your first statement is not supported by the second. Yes, in a DV situation or a situation where someone has severe mental illness, it's probably not a good idea to have easy access to a firearm. But if you actually look at the numbers, the average firearm is not used in self-defense, nor is it used to endanger a family member. The vast majority just . . . sit there. They're machines which must be used respectfully a…

> The vast majority just . . . sit there. This is irrelevant to the statement that having a gun around is more dangerous than not having a gun around. https://med.stanford.edu/news/all-news/2020/06/handgun-owner... https://med.stanford.edu/news/all-news/2022/04/handguns-homi...

> Men who owned handguns were eight times more likely than men who didn’t to die of self-inflicted gunshot wounds.

> Women who owned handguns were more than 35 times more likely than women who didn't to kill themselves with a gun.

That is specific to handguns and kind of what would be expected?

Also, being more likely than not likely at all is pretty much comparing degrees of impossibility.

Seems like this pops up in arguments often.

Something like:

"We need to stop this bad thing that rarely happens! Only when it happens even less than hardly ever will we all be safe!"

Re: Psilocybin desynchronizes the human brain

#153

Post by l33tbro »

motohagiography wrote: post #134

Feedback in an anlog signalling system producing delays, reflections, geometric and clipped artifacts is something anyone who has used a guitar effects pedal is familiar with. I have a surprising number of old comments on this site about how hallucinogens just impair signalling and the results are geometric for the same reasons. This article says it impairs the equivalent to the CLK signal, which sounds just about ri…

The problem is getting so out of it that you can't reach the wet/dry knob to dial back the wacko.

Re: Psilocybin desynchronizes the human brain

#154

Post by zdragnar »

SoftTalker wrote: post #150
muzani wrote: post #149

Earlier quoted context omitted.

Yeah, I think data on this would be hard to get. A tangential anecdote... I took a Pfizer COVID booster vaccine and saw my heart rate go up to resting above 100 on my calorie tracker watch. I talked with my doctor about this. He said he stayed away from the COVID boosters because they weren't a good balance of risk vs safety. I asked him whether high resting heart rates were a side effect. He said, no, there's no dat…

> I took a Pfizer COVID booster vaccine and saw my heart rate go up to resting above 100 Temporarily or permanently?

My brother has this permanently, though whether a delayed reaction to the booster or from when he got COVID itself (a relatively mild case) not long after, there's no way to know.

It has been a major detriment to his day to day life though. Any physically involved hobbies are impossible; just walking up a flight or two of stairs now leaves him completely winded for several minutes, as his heart rate also takes longer to come back to resting than before.

Would not recommend.

Re: Psilocybin desynchronizes the human brain

#155

Post by azurelake »

_rs wrote: post #151
brotchie wrote: post #104

Earlier quoted context omitted.

Agreed. Before a controlled high dose Psilocybin experience I "felt" my emotions: Anger, Fear, Frustration. Afterwards, I gained the ability to observe and "catch" my emotions in-flight. Not sure if it was neuroplasticity induced by the substance, or "you don't know what your brain can do until you know it". I liken it to previously having Ring 1 access to my thoughts, now I have Ring 0 access. Definitely persistent:…

Do you mean you can catch them and stop them? Or catch them and say "oh I'm starting to feel angry" without letting the anger consume you, but still let it exist. I'd love any elaboration you can share on this

Your second sentence is more on the right path (speaking for myself at least). It's about labeling and observing the literal physiological sensation that is occurring in your body and choosing how to react vs. identifying strongly with the current emotion and reacting.

Easier said than done, of course!

Re: Psilocybin desynchronizes the human brain

#156

Post by shrimp_emoji »

azurelake wrote: post #155
_rs wrote: post #151

Earlier quoted context omitted.

Do you mean you can catch them and stop them? Or catch them and say "oh I'm starting to feel angry" without letting the anger consume you, but still let it exist. I'd love any elaboration you can share on this

Your second sentence is more on the right path (speaking for myself at least). It's about labeling and observing the literal physiological sensation that is occurring in your body and choosing how to react vs. identifying strongly with the current emotion and reacting. Easier said than done, of course!

And mindfulness meditation is training yourself to detach your conscious sense of self from those physiological sensations, noticing but not reacting to them at all!

Re: Psilocybin desynchronizes the human brain

#157

Post by op00to »

muzani wrote: post #149
__MatrixMan__ wrote: post #110

Earlier quoted context omitted.

Anecdotal, but I've tripped with two people who showed seizure like symptoms that they never had before or since. Couldn't find any data at the time. Tried to get them to submit experience reports on erowid so that there would be some data out there, but they didn't want to put anything about it in writing.

Yeah, I think data on this would be hard to get. A tangential anecdote... I took a Pfizer COVID booster vaccine and saw my heart rate go up to resting above 100 on my calorie tracker watch. I talked with my doctor about this. He said he stayed away from the COVID boosters because they weren't a good balance of risk vs safety. I asked him whether high resting heart rates were a side effect. He said, no, there's no dat…

Your heart rate increases in response to immune system activation. Like if you catch a cold or get a vaccine. Your doctor sounds like a quack.

Re: Psilocybin desynchronizes the human brain

#158

Post by newzisforsukas »

jeremiahbuckley wrote: post #75
TechDebtDevin wrote: post #17

PSA: My buddy shot himself in the head while we were on shrooms in our twenties. He thought he meant God, took a shower picked up a gun and shot himself in the head. While I've had trips since then and do get benefits from those experiences. People without experience should be careful, especially if you have a history of mental illness. He did have a history to some degree but not overtly.

A user named observationist made a response to this post, but they responded to a troll, whose comment was nuked which removed their very valuable comment (I was responding to them at the time so I happened to have both in cache). observationist https://news.ycombinator.com/user?id=observationist original comment: Around 1% of people have schizophrenia. This holds over a lifetime - there's a structural, unavoidable c…

Isn't asking an LLM to find links that support an assertion equivalent to cherry picking sources? Also, just from a quick scan of some of these, it is apparent that the citations are not completely accurate.

IMO, this is kind of asymmetric lazy commenting that wastes other peoples' time. If you want to share something, just link to a article, and leave the LLM bullshit out of it.

Re: Psilocybin desynchronizes the human brain

#159

Post by tambourine_man »

muzani wrote: post #149
__MatrixMan__ wrote: post #110

Earlier quoted context omitted.

Anecdotal, but I've tripped with two people who showed seizure like symptoms that they never had before or since. Couldn't find any data at the time. Tried to get them to submit experience reports on erowid so that there would be some data out there, but they didn't want to put anything about it in writing.

Yeah, I think data on this would be hard to get. A tangential anecdote... I took a Pfizer COVID booster vaccine and saw my heart rate go up to resting above 100 on my calorie tracker watch. I talked with my doctor about this. He said he stayed away from the COVID boosters because they weren't a good balance of risk vs safety. I asked him whether high resting heart rates were a side effect. He said, no, there's no dat…

That doctor of yours should have their license revoked.

Re: Psilocybin desynchronizes the human brain

#160

Post by EasyMark »

asveikau wrote: post #109
greentxt wrote: post #101

Earlier quoted context omitted.

Doubtful. Shrooms cause seizures.

Something tells me seizures have multiple causes and if the drugs is one cause it's not a cause for everybody.

I think so too. It’s like saying colds, covid, flu, nausea cause coughing, it’s a general symptom. Seizures are caused by many conditions.
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