In March 2023, Novo Nordisk was suspended from the ABPI for a period of two years, for engaging in misleading marketing practices that amounted to "bribing health professionals with inducement to prescribe".[59] This is only the eighth time in the last 40 years that ABPI sanctioned a member organization.
Ozempic will disrupt big tobacco, candy companies, and alcohol brands
151–160 of 214 posts
Re: Ozempic will disrupt big tobacco, candy companies, and alcohol brands
#152We could also clamp down on addictive shit like Doritos and Oreos like we did with tobacco. Unbelievable that people will need to take a drug to escape the treachery of junk food companies everywhere you turn.
To achieve similar controls over sugar (and specifically fructose) as those put in place by eg the Cigarette Labeling and Advertising Act[0] (which mandated Surgeon General's warnings on cigarette packaging), the Public Health Cigarette Smoking Act of 1970[1], and the Family Smoking Prevention and Tobacco Control Act of 2009[2], we might need to first see lawsuits similar to those against tobacco companies. Litigation played a major role in shifting public opinion and policy, eg the 1998 Tobacco Master Settlement Agreement[3].
0. https://en.wikipedia.org/wiki/Cigarette_Labeling_and_Adverti...
1. https://en.wikipedia.org/wiki/Public_Health_Cigarette_Smokin...
2. https://en.wikipedia.org/wiki/Family_Smoking_Prevention_and_...
3. https://en.wikipedia.org/wiki/Tobacco_Master_Settlement_Agre...
Re: Ozempic will disrupt big tobacco, candy companies, and alcohol brands
#153Earlier quoted context omitted.
Can you articulate those dangers? Compounding is a well developed means of sourcing drugs and GLP has been around for decades. What specifically should people be mindful of?
Well quality of the compounder/pharmacy is the real issue here -- of course it's not that the process itself is flawed, more that it's basically impossible for a layman consumer to inspect/assess quality/safety.
How does the layman consumer inspect/assess the quality/safety of other drugs or really any other substance that they ingest?
Re: Ozempic will disrupt big tobacco, candy companies, and alcohol brands
#154Earlier quoted context omitted.
If they invent something like this but for procrastination, they'd get a Nobel prize.
Oh God, imagine the self-, peer, and top-down pressure to take that, both for students and working adults.
No need to imagine, there's a reason Adderall, Vyvanse, and just about any amphetamine are banned in Japan.
Re: Ozempic will disrupt big tobacco, candy companies, and alcohol brands
#155I'm not very familiar with the approval process for new drugs, but as far as I know it involves some initial step where the safety is assessed, and then the effectiveness. But I don't think either of those are actually long term processes (like, longer than 5 years). So it scares me a bit when something like Ozepmic pops up and tons of people jump on it, without knowing the long term effects that might appear. I read…
Semaglutide has been on the market since 2017 and clinical trials commenced in 2008. So we have a fair amount of data on longer-term users. It wasn't being used for general obesity until recently.
But has it had long-term studies as a weight-loss drug instead of a diabetes treatment? The results might be different.
Re: Ozempic will disrupt big tobacco, candy companies, and alcohol brands
#156Earlier quoted context omitted.
Pharma is notorious for changing the formulation just enough to acquire a new patent to restart the clock. I wouldn't be surprised if the dosage was a factor in the process.
That doesn’t mean the existing drug can’t be sold as a generic.
Sometimes it means exactly that:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968089/
Of course you could still sell the same drug if you get it approved with a different dosage but that is a long and costly process.
Re: Ozempic will disrupt big tobacco, candy companies, and alcohol brands
#157Earlier quoted context omitted.
Would it? Drug manufacturers don't really do as much 'R&D' as we assume, they buy biotech companies that have already discovered drugs. Also, why would a company stop wanting to make money? 'We are only going to make $5billion instead of $15 billion, let's not bother with that one.'
> 'We are only going to make $5billion instead of $15 billion, let's not bother with that one.' Well, yes. If there's a 10% chance of success, these differences matter. Decision making happens at the margin.
How would they know how much one drug would make vs the other while in the research phase?
Re: Ozempic will disrupt big tobacco, candy companies, and alcohol brands
#158Earlier quoted context omitted.
I mean come up with a pill that changes your eating habits and doesn't just repress them. Don't think anyone's got close to that yet. In the meantime overweight people are going to take what they can get.
Tobacco did that (imagine going for nicotine patches instead of smoking), meth did that, a lot of things do that. It all comes down to the side effects and whether it's worth having the drug around. Up until now we say "no, fuck it" after a few decades of having the thing widely available. My point is wether we should shortcut the cycle and so no _before_ doing the society wide trial and having to fight for decades t…
Tobacco and meth happen to be some of the most highly addictive drugs that exist, that also have the side effect of weight loss.
I don't think I've seen anybody tweaking out for a fix of ozempic, though please feel free to inform me if addiction is an actual side effect that I've not heard of.
Re: Ozempic will disrupt big tobacco, candy companies, and alcohol brands
#159Earlier quoted context omitted.
That doesn’t mean the existing drug can’t be sold as a generic.
Sometimes it means exactly that: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968089/ Of course you could still sell the same drug if you get it approved with a different dosage but that is a long and costly process.
That still presupposes a new patent with new dosage.
In this case, is there a dosage patent on ozempic’s current dosage? If manufacturers tweak ozempic’s current dose and get a patent, what’s to stop the existing dosage from being made by generics?
Re: Ozempic will disrupt big tobacco, candy companies, and alcohol brands
#160Ozempic costs $1000/month (in the US) but $5/month to manufacture [0]. I think if this drug and others are to have a significant anti-consumption effect on other companies it needs to be vastly more accessible, which first requires more accessible healthcare in the US, which is unlikely to happen. Also it's an injection, which raises the barrier. If drugs like these become orally administered and over-the-counter, th…
Ozempic is the injectable version of semaglutide. Rybelsus is the orally administered form. It has been available for several years but isn’t as effective as the injection.
Eli Lilly who makes the Ozempic rival Mounjaro is in late stages of clinical trials for their oral GLP-1 medication.