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FDA approves a CRISPR-based medicine for treatment of sickle cell disease

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Re: FDA approves a CRISPR-based medicine for treatment of sickle cell disease

#151
post #44

The gene that causes sickle cell anaemia actually provides partial immunity to malaria, which is why this gene has not been bred out of the population over time.

Correct, but if we have good treatments for malaria (e.g. hydroxychloroquine, atorvaquinone) then I would argue that we no longer need that partial immunity

Re: FDA approves a CRISPR-based medicine for treatment of sickle cell disease

#152
post #139
post #120

Earlier quoted context omitted.

I would have bred them for more potato protein. It's a very close meat protein substitute by essential amino acids. Might be why it tastes so good. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245118/ >Of the ten plant-based proteins included in the current analysis, potato protein is the only protein source containing the WHO/FAO/UNU requirements for all essential amino acids. Thus, when consuming potato protein as…

I supplement protein, filtered for vegan because my body doesn't like whey, and Pea protein is pretty solid. It's a "complete" protein and doesn't require any complicated processing steps, just drying, pulverizing, and a centrifuge step to spin out the fiber.

Are you sure that's all they do? Peas aren't even close to 100% protein, so you'd be eating a very high-carb powder if that were the case.

Re: FDA approves a CRISPR-based medicine for treatment of sickle cell disease

#153
post #44

The gene that causes sickle cell anaemia actually provides partial immunity to malaria, which is why this gene has not been bred out of the population over time.

Good point and thanks for being on-topic. Humans have three variants of the HBB gene and having sickling mutations in the variant expressed in adult is causal to SC disease. The FDA-approved treatments reactivate the fetal HBB gene in adults and this change in gene expression control effectively prevents SCD. Very cool and transformative work. Now we have to get the price tag down from seven figures to four or five f…

From an efficiency standpoint, I think having to harvest and modify the patient's stem cells is probably the biggest choke point, right? I would imagine that if you could inject something once and be done with it (I'm thinking like Zolgensma), you could mass produce it more effectively

Re: FDA approves a CRISPR-based medicine for treatment of sickle cell disease

#154

Earlier quoted context omitted.

You might enjoy Cronenberg’s Crimes of the Future if that idea is appealing to you. Very curious execution of a disease-free bio-tech (organ-ic-tech?) future.

I just wanna be able to digest plastic

I was wondering about new digestive capabilities recently and wrote this blurb:

https://clonk.me/nft/137/0x8abd8d9fab3f711b16d15ce48747db496...

If we could eat different things, we could give up agriculture and save a bunch of land and energy.

Re: FDA approves a CRISPR-based medicine for treatment of sickle cell disease

#155

Earlier quoted context omitted.

I don't agree that it is nothing. 2 millions, if applied properly, could do good for many people. Take ten children from poverty, give ten children chance to get a good education, etc. There is always a some kind of moral dilemma: should you spent millions to try to extend extremely I'll person or help with that money to some healthy poor children?

> 2 millions, if applied properly, could do good for many people. Its very close to the lifetime average financial cost of medical services related to sickle cell disease for those with it, from things posted elsewhere in the thread. So its literally just paying the same (loosely) financial cost up front and then not having them suffer through the disease. An incentive structure that encourages mostly making the wron…

To be fair, those incentive structures also encourage the development of what everyone knows going in will be—initially—absurdly expensive treatments.

Over-under on when the NHS agrees to pay for this?

Re: FDA approves a CRISPR-based medicine for treatment of sickle cell disease

#156
post #143

Earlier quoted context omitted.

Insurable risk as in charging someone an appropriate premium that is based on their specific expected loss. Property and casualty, term life, etc. Non insurable risk as in charging someone a premium unrelated to their specific expected loss (which is what health “insurance” is).

How exactly are health insurance premiums "unrelated" to care outflows (what you're calling "expected loss")? Are you saying that health insurers books don't balance and that they're losing money (they aren't) or making too much profit (not unless they're criminally hiding it)? What you're saying doesn't make sense. There's no difference between health insurance and any other insurance in the way it works. You collec…

I meant the premium for a specific person is not related to their expected loss.

For example, if you carelessly drive and get into car collisions where you are at fault, your premiums go up, because your expected loss goes up.

In health “insurance”, it does not matter what you do, because your premiums are not based on your expected health costs. Hence it is more akin to a tax (or subsidy).

Re: FDA approves a CRISPR-based medicine for treatment of sickle cell disease

#157
post #152
post #139

Earlier quoted context omitted.

I supplement protein, filtered for vegan because my body doesn't like whey, and Pea protein is pretty solid. It's a "complete" protein and doesn't require any complicated processing steps, just drying, pulverizing, and a centrifuge step to spin out the fiber.

Are you sure that's all they do? Peas aren't even close to 100% protein, so you'd be eating a very high-carb powder if that were the case.

Yep, here's an article [1] describing the process. Here's some youtube video I found showing the various steps [2].

They don't have to use any chemical solutions more exotic than water and air. I bungled the explanation with "centrifuge", it's more complicated than that, but the fiber content is removed in that step.

[1]: https://gogood.co.nz/blogs/news/how-is-pea-protein-manufactu...

[2]: https://www.youtube.com/watch?v=wbX_w0ZIunM

Re: FDA approves a CRISPR-based medicine for treatment of sickle cell disease

#158

Earlier quoted context omitted.

Are you concerned about off-target edits activating toxin producing pathways?

Maybe they are referring to the small percentage of people are sensitive to the whole family (potatoes, tomatoes, peppers, tobacco, etc) and find any exposure produces inflammation/digestion issues.

yes it's both actually! Potatoes are wildly toxic to humans when they have any green on them, and that can actually happen in the refrigerator if left to long and then consumed. They have the capacity to really F us up. Editing those strikes me as like threading a needle between hair triggers. You don't want to miss your target.

But also yes exactly, the whole family can cause inflammation and difficulties in people sensitive to them (which tragically because I love spicy food, includes me D-:). So that means that any cool stuff they do I won't be able to try.

Re: FDA approves a CRISPR-based medicine for treatment of sickle cell disease

#159
post #152
post #139

Earlier quoted context omitted.

I supplement protein, filtered for vegan because my body doesn't like whey, and Pea protein is pretty solid. It's a "complete" protein and doesn't require any complicated processing steps, just drying, pulverizing, and a centrifuge step to spin out the fiber.

Are you sure that's all they do? Peas aren't even close to 100% protein, so you'd be eating a very high-carb powder if that were the case.

Hence the "spinning out the fiber" bit. Likewise, whey protein is a byproduct of cheesemaking where fat gets separated from milk, otherwise it'd be a very high-fat powder.
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