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Significant breakthrough in search for Parkinson's biomarker

michaeljfox.org

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Re: Significant breakthrough in search for Parkinson's biomarker

#151

Earlier quoted context omitted.

What would you do if you found out you would? (I ask as someone whose great-grandfather, great-uncle, and grandfather all had Parkinson’s.) I’ve avoided any testing because, as far as I know, there’s nothing preventative to be done. I’d love to hear otherwise. I’ve broached the subject with my last two primary care physicians and both advised that there was no point in knowing.

Pick up a nicotine addiction. Seriously, it has long been understood that people who smoke have dramatically lower levels of parkinsons. It comes from the neuroprotective properties of nicotine. You don't have to become a smoker, you could theoretically use any of the other forms (vape, gum, patch)

Curious if you have any links to support lower incidence of Parkinsons for smokers. I found this, which states that nicotine does not slow the disease once started: https://www.michaeljfox.org/news/nicotine-patch-not-benefici...

Re: Significant breakthrough in search for Parkinson's biomarker

#152
post #149

Earlier quoted context omitted.

Cool, let’s make the companies that caused it pay for it

That's why we have the EPA Superfund program https://en.wikipedia.org/w/index.php?title=Superfund

Santa Clara county has the most superfund sites.

Re: Significant breakthrough in search for Parkinson's biomarker

#153

Earlier quoted context omitted.

It's not allowed. These are old plumes and they stay around for a long time and are very expensive to clean up.

Cool, let’s make the companies that caused it pay for it

Many of those companies no longer exist...

Re: Significant breakthrough in search for Parkinson's biomarker

#154

Earlier quoted context omitted.

Pick up a nicotine addiction. Seriously, it has long been understood that people who smoke have dramatically lower levels of parkinsons. It comes from the neuroprotective properties of nicotine. You don't have to become a smoker, you could theoretically use any of the other forms (vape, gum, patch)

Curious if you have any links to support lower incidence of Parkinsons for smokers. I found this, which states that nicotine does not slow the disease once started: https://www.michaeljfox.org/news/nicotine-patch-not-benefici...

I'd encourage you to just search google scholar for "nicotine and parkinsons" there are dozens and dozens of studies. It's been well established for decades now, as it stood out, especially in the past, that cigarette smokers weren't developing parkinsons as expected. Here is a recent meta study though:

https://www.sciencedirect.com/science/article/abs/pii/S01674...

There have also been numerous studies that have found that starting nicotine once symptoms begin is too late, with little or no effect. It is hypothesized that there is some critical point that once crossed, nicotine no longer has an effect. Parkinsons is believed to slowly develop over years or decades, and nicotine stunts this early progression.

Re: Significant breakthrough in search for Parkinson's biomarker

#155
post #138

For those living in the bay area, you should know that the groundwater in many areas is contaminated with TCE due to computer manufacturing industry which used it as a solvent. Dry cleaners are another common culprit of contamination to the groundwater. These groundwater plumes can extend for quite a large distance from the original site of contamination and seep into the first story of residences and buildings throu…

This Twitter thread on the specifics of how dry cleaning retail stores contribute to the problem is an excellent quick overview:

https://twitter.com/realEstateTrent/status/14378028033139220...

Re: Significant breakthrough in search for Parkinson's biomarker

#156

Earlier quoted context omitted.

Certain pesticides are confirmed causes of Parkinsons. Don't remember which now, but could look it up.

No, none are "confirmed causes". There are mild associations between the use of certain pesticides and Parkinson's, but much lower than the overall genetic risk factors, and there's always the possibility of confounding factors in the studies.

What's your source, if you don't mind me asking? I ask because some pesticides are well established to be linked to increased risk of parkinson's. Including carbamates (3.5x), organophosphorus (2x) and organoclorine (2x).

https://pubmed.ncbi.nlm.nih.gov/33991619/

Re: Significant breakthrough in search for Parkinson's biomarker

#157

Earlier quoted context omitted.

That's the precise essence of why quackery is dangerous. People are searching for "every possible way that can help" and quackery can easily exploit that natural tendency. (I am not qualified to render any opinion on whether this specific protocol is quackery.)

The problem is the lack of incentives to take the “huh that’s interesting, but I don’t know if I can trust it because it’s published in a quack journal” … and ever reproduce the research and get it into more trusted more prestigious journals. There’s a reproducibility crisis in many fields of research, and medical research has multiple confounding factors, the “no prestige in just redoing the research”, lack of money…

If you had a legitimate research finding, why would you publish it in a quack journal?

Presumably, because the more prestigious journals declined to publish it.

Why did all of them decline to publish it? There was probably a reason. A paper being published in a quack journal does actually carry a signal about the quality of paper, IMO. No one turns down publishing in Cell or Neuron to publish in Donald's Journal o' Quackery and Crockpot Recipes.

Re: Significant breakthrough in search for Parkinson's biomarker

#158
post #89

Interesting that big flu outbreaks cause a long term spike in Parkinson's - how much more will be traced back to the impact of viruses? Saw that come up as a worry around Covid, seems the loss of smell/taste is a commonality with Parkison. We will not know for a decade or two though, but these biomarkers might help accelerate measuring the impact.

It’s very plausible in 10-20 years or so. Studies found a massive increase in acting out of dreams amongst those who had Covid. This acting out of dreams is a very strong precursor to Parkinson’s. According to this, 80% of people with it get Parkinson’s within 20 years. https://www.salon.com/2023/04/24/long-parkinsons/

Well that certainly puts a dark twist on the phrase "living the dream".

Re: Significant breakthrough in search for Parkinson's biomarker

#159
post #138

For those living in the bay area, you should know that the groundwater in many areas is contaminated with TCE due to computer manufacturing industry which used it as a solvent. Dry cleaners are another common culprit of contamination to the groundwater. These groundwater plumes can extend for quite a large distance from the original site of contamination and seep into the first story of residences and buildings throu…

What can I do if I live near one of the red spots? Do air and water filters help?

Re: Significant breakthrough in search for Parkinson's biomarker

#160

Earlier quoted context omitted.

> Parkinson's has many forms and many causes. A lot of my family were farmers. I've had close relatives die with severe Parkinsons, primarily those that farmed their whole life. Their theory was that it was really exposure to a lot of toxic farm chemicals. I can imagine Parkinsons turning out to be several different conditions with similar symptoms.

In The Netherlands we have A LOT of farmers with parkinsons. Most, if not all cases seem to be related to Roundup/Glyphosate.

Roundup/Glyphosate is such a nasty chemical. Farmers use it in practice regularly for crop desiccation [1] in order to yield more harvest cycles. Why do we still allow it knowing what we know?

[1] https://en.wikipedia.org/wiki/Crop_desiccation

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