Live data from Hacker News

Fentanyl vaccine tested in rats

uh.edu

151–160 of 378 posts

Re: Fentanyl vaccine tested in rats

#151
post #8

Earlier quoted context omitted.

Yeah but my understanding is that most of the overdosing are from people seeking something else. In some cases it’s akin to a contamination problem.

We are at the point in the fentanyl epidemic where most users are specifically seeking out fentanyl or fentanyl laced drugs.

I suspect most people looking for cocaine or methamphetamine or mdma are not looking for fentanyl.

Re: Fentanyl vaccine tested in rats

#152

The real issue here that people don't seem to want to face is the WHY. Why do so many people want to check out of life completely by abusing medicine? If we don't address that nothing is going to stop the drug abuse let alone the relapse and overdose. I'm not talking about "more 12 step" here but more of a Frommian psychoanalytic approach. You are broken because society is broken. You have the ability to change yours…

They’re adding Fentanyl to everything now. I have Burning Man-adjacent friends who take ecstasy once a year at festivals, and they’re terrified of getting a tainted dose. This affects many more people than just those addicted to opiates.

I think this highlights the importance of addressing the _why_ even more. Most people are terrified of accidental fentanyl exposure. Some people seek it out. Why is that?

Re: Fentanyl vaccine tested in rats

#153

The real issue here that people don't seem to want to face is the WHY. Why do so many people want to check out of life completely by abusing medicine? If we don't address that nothing is going to stop the drug abuse let alone the relapse and overdose. I'm not talking about "more 12 step" here but more of a Frommian psychoanalytic approach. You are broken because society is broken. You have the ability to change yours…

I think you presume that human behavior must seem to have a cognitive reason for the "why", when it's entirely possible that the "why" is simply physiological/neurological. In the case of intense opiates, which have a profound effect on human neurology, it would be bizarre to not consider that in the "why".

Re: Fentanyl vaccine tested in rats

#154
post #53

Oh boy, the pharmaceutical companies can sell a new product to help solve the mess that one of their previous products created. An opioid that's more potent, more addictive, and more deadly than heroin should never have gone to market in the first place. It speaks of enormous corruption and a complete lack of ethics when regulators didn't see an issue with fentanyl and let it move forward. The "but people are in pain…

If I fall off a ladder and break my leg, I want the good stuff. I’ve found old bottles of expired Vicodin and such around that I was prescribed but never finished. I have zero interest in recreationally using opiates. I also have zero interest in bravely tolerating agonizing pain if I don’t have to.

It's easy to say this when you already know that you, personally, can resist the temptation of abusing drugs like Vicodin.

Personally, I refuse all pain killers except OTC and local anesthetics like novocaine. I rather risk biting through my tongue than getting addicted to that shit.

Re: Fentanyl vaccine tested in rats

#155
post #139

Earlier quoted context omitted.

They’re adding Fentanyl to everything now. I have Burning Man-adjacent friends who take ecstasy once a year at festivals, and they’re terrified of getting a tainted dose. This affects many more people than just those addicted to opiates.

Legalize everything and produce it pharmaceutically, and this problems pretty much disappears.

MDMA became dangerous after it was made illegal.

When it was legal, it was made by chemists in labs who cared.

The problem with legalizing drugs is ensuring the greedpigs don't take over the industry and actually dealing with the root causes of addiction.

Re: Fentanyl vaccine tested in rats

#156

The real issue here that people don't seem to want to face is the WHY. Why do so many people want to check out of life completely by abusing medicine? If we don't address that nothing is going to stop the drug abuse let alone the relapse and overdose. I'm not talking about "more 12 step" here but more of a Frommian psychoanalytic approach. You are broken because society is broken. You have the ability to change yours…

I think this undermines the issue a bit. A lot of people get addicted to these substances completely by accident and aren't initially seeking to "check out of life." But once you are hooked, it can be a devastatingly difficult road to get off. For sure there are plenty of people who go out looking for escapes and I do agree it is something that needs to be addressed.

Re: Fentanyl vaccine tested in rats

#157
post #42

[flagged]

You are correct, and I'm surprised at the backlash. Nearly all of the illegal fentanyl in the country has an origin in China, when captured and traced. Personally, it doesn't surprise me, as I imagine it's China getting back at the West over the Opium Wars. As horrible as it is, there is a certain amount of logic to the act, especially if considered from the perspective of societal scale destabilization.

The US has done similar things in the past, including against our own citizens. The CIA helped cartels traffick cocaine and started the crack epidemic amongst black communities in the US. It shouldn't surprise anyone that a state actor is involved in driving and deepening the opioid epidemic.

Re: Fentanyl vaccine tested in rats

#158
post #133

Does this prevent death or just the perceived effects of the drug? This could be very dangerous for users who relapse. There is a known pattern of users who get off opioids then relapse and die because their bodies can no longer tolerate the doses that they were used to taking before they quit. This could have a similar effect where users take the drug, don't feel it, and then increase their dose to lethal levels hop…

Can you elaborate on your point of confusion? The mechanism of action was explained in the article.

That's strange that they describe the selling point as being that you can't get high anymore. If it's really attacking and neutralizing the chemical per se, and if it's truly neutralized in every way, that would mean it would stop overdoses. That seems like a much bigger selling point.

Re: Fentanyl vaccine tested in rats

#159

Earlier quoted context omitted.

Yeah, and a whole host of other problems show up…

can you elaborate?

- The black market is always cheaper.

- Even in a legal market how many people are always buying their own?

- If everything is legal then it's even easier for people to spike drinks and the like.

- Purdue Pharma marketing issue writ large.

- Patients pressuring their doctors to prescribe, or alternatively feeling pressured by their doctors to use a particular drug.

- If it's legal it's easier to purposefully or accidentally overdose (e.g. alcohol today). Especially if it's also cheaper.

Off the top of my head.

Re: Fentanyl vaccine tested in rats

#160

The real issue here that people don't seem to want to face is the WHY. Why do so many people want to check out of life completely by abusing medicine? If we don't address that nothing is going to stop the drug abuse let alone the relapse and overdose. I'm not talking about "more 12 step" here but more of a Frommian psychoanalytic approach. You are broken because society is broken. You have the ability to change yours…

> The real issue here that people don't seem to want to face is the WHY. Why do so many people want to check out of life completely by abusing medicine

People start using drugs for different reasons. It's not correct to say that everyone starts abusing drugs as a form of pure escapism. A lot of drug users start because they're simply seeking recreation and someone is nearby to make drugs available to them. It's as simple as that.

> You are broken because society is broken.

Variations of this concept are frequently used by drug addicts to justify continued behavior. "It's not my fault, it's society's fault!". Taking ownership of actions and consequences is one of the key pivot points in helping people get control.

Post reply on HN