Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

age.mpg.de

Post reply on HN
Print view View original

151–160 of 228 posts

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#151

Post by fnordpiglet »

crypticlizard wrote: post #141
jonathan-adly wrote: post #87

Just putting this out there, I am a PharmD and this is totally real and the traditional medical establishment is really behind. It is positive effects are beyond doubt - the argument against it is usually "we don't know what the side effects if 100m+ went on it for 20+ years". (which is also 100% true, but that's where patient autonomy comes in). Also, there are some questions about how much are really the positive e…

Could you comment on if you think there is a natural analogue out there? Even if less effective? For example a quick google search led me to this: https://www.nutraingredients-usa.com/Article/2017/12/01/Ashw... Which is suggesting Ashwagandha might a candidate for Rapamycin and Metformin mimcry.

If you eat dirt from Easter island you’ll get some and it’s totally natural.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#152

Post by gavinmckenzie »

kvetching wrote: post #106

Quoted post unavailable.

A discussion around the numbers of medically-assisted death and what can be done to reduce those numbers through better treatments and services would be a worthy discussion.

But it’s inaccurate and needlessly provocative to say that the government is killing people through euthanasia. The government made it possible for people to seek medical assistance in ending their own lives.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#153

Post by evo_9 »

gadders wrote: post #81
evo_9 wrote: post #63

I'm a month into taking rapa and already I feel like it's having a noticeable effect. I'm curious what others on this threads dosage looks like. If you prefer to keep it private, you can email me directly (my email is on my profile). I'm currently taking 2mg once a week on my rest day; I started with 1mg and after 1 month added another MG. I'll continue each month until I reach 8MG once a week, which is the dosage th…

What's NMN?

Yeah as others appointed out it’s a nad+ precursor.

I feel compelled to comment though because anytime I read about how this stuff is only been tested in worms in mice… That automatically discount it’s worth as something to consider.

I’m gonna sah what I said before - I’ve played high-level hockey my whole life, I’m now 55 and I play against guys that barely washed out of their pro career.

When I stop taking nmn for two months my speed dropped from 20+ Mph to the mid teens.

A week after resuming my NMN supplementation my speeds are back in the 23-24 mph range

There’s just no way to fake it against players of this caliber. And to be clear I don’t know anybody even close to my age competing at this level.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#154

Post by fatuna »

dsign wrote: post #29

When somebody asks about what is the next big thing, I always think on anti-aging. If you think that you don’t want to live forever, imagine that today when you arrive home you find a note saying that you will die exactly 1531[^1] days from today. How would you feel? With that said, I would stay away from miracle drugs, because no two human beings have the same physiology. But that’s not an unsolvable problem. [^1]:…

I think this is a great example of "what's good for the individual, is bad for humanity as a whole". Imagine we'd discovered a drug that adds 100 years to a persons natural life. Now imagine this drug was discovered 100 years ago. J.D. Rockefeller and the likes would still be alive and influencing politics. I can't even begin to think how much humanity would stagnate after such an invention.

See also the Planck principle: "A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die and a new generation grows up that is familiar with it"

https://en.wikipedia.org/wiki/Planck%27s_principle

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#155

Post by SketchySeaBeast »

ipaddr wrote: post #149
SketchySeaBeast wrote: post #120

Earlier quoted context omitted.

I think it's fair to say that we don't have to do something just because there's a plausible mechanism for a benefit. If there are clear and obvious health benefits that are far beyond what you see with a regular calorically restricted diet, I haven't heard them well explained.

https://www.hopkinsmedicine.org/health/wellness-and-preventi... .

The points listed there include heart health and the prevention of diabetes and obesity, which are very clearly things traditional caloric restriction also help with. For the other claims I don't see any comparison with traditional caloric restriction (I can't access the source paper).

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#156

Post by WastingMyTime89 »

deegles wrote: post #127

I'm 35, have been taking 6mg of rapamycin per week for about a year. It's hard to assign the effects directly to it since I've been taking other supplements and also fixing up my diet + exercise. That being said, I am quite sure that it has reduced general aches and pains, reduced visceral fat and I now have less gray hair compared to when I started. It did slightly increase my glucose and lipids, but still within sa…

This comment is quintessential to the issue with HN.

So you are quite young, just had a complete change of lifestyle and your take away is that the beneficial effect comes from the drug you take randomly amongst a cocktail of other things.

Interesting.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#158

Post by DoreenMichele »

deegles wrote: post #127

I'm 35, have been taking 6mg of rapamycin per week for about a year. It's hard to assign the effects directly to it since I've been taking other supplements and also fixing up my diet + exercise. That being said, I am quite sure that it has reduced general aches and pains, reduced visceral fat and I now have less gray hair compared to when I started. It did slightly increase my glucose and lipids, but still within sa…

I now have less gray hair compared to when I started.

I've never taken rapamycin nor even heard of it before today. I have less gray hair than I had twenty years ago.

My understanding is that gray hair suggests a B vitamin deficiency, especially PABA, and a need for adrenal support.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#159

Post by derefr »

BiteCode_dev wrote: post #103
jonathan-adly wrote: post #87

Just putting this out there, I am a PharmD and this is totally real and the traditional medical establishment is really behind. It is positive effects are beyond doubt - the argument against it is usually "we don't know what the side effects if 100m+ went on it for 20+ years". (which is also 100% true, but that's where patient autonomy comes in). Also, there are some questions about how much are really the positive e…

What makes me scared about this is that it's immunosuppressive. The immune system is a very important part of the human body, and I worry that taking it could have terrible health impact after years of acting on your body lines of defense. What can you tell me about it?

If you think about it, there are specific parts of our immune systems that are likely entirely maladaptive given modern civilization, where people are ~never exposed to parasites, animal venoms, etc.

We can turn those parts off, while leaving everything else on, and be better for it (no allergies, psoriatic arthritis, MS, Chron’s, etc.; and so none of the accelerated cellular senescence those conditions provoke in affected tissue.)

A lot of recent pharma is already focused on doing specific forms of this at low levels. Every other drug ad in the US is for an immune-receptor blocker of some kind. And the side effects of these drugs come down mostly to the fact that they’re too low-level — they stop these parts of the immune system from being called into action at affected sites, but they leave it active and “patrolling”, such that it attacks harder any tissues that don’t absorb the receptor-blocker well, and such that you get withdrawal effects of potential inflammatory crisis if/when it wears off.

Just deactivating the relevant parts of the immune system entirely, on the other hand, provides the same benefits these drugs do, but with none of the “now the rowdy enforcers have nothing better to do, so they go looking for trouble” drawbacks.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#160

Post by nico »

jonathan-adly wrote: post #113
BiteCode_dev wrote: post #103

Earlier quoted context omitted.

What makes me scared about this is that it's immunosuppressive. The immune system is a very important part of the human body, and I worry that taking it could have terrible health impact after years of acting on your body lines of defense. What can you tell me about it?

Your concern is correct. Suppressing the immune system is a 2-edged sword - a little suppression in the right setting, is extremely beneficial, but go overboard and it is harmful. That's why in a perfect world, we would have large human trials with different dosages and iterate until we can get the maximum benefit and the least harm. The problem is, no one wants to do those trials because rapamycin is cheap and gener…

> The problem is, no one wants to do those trials because rapamycin is cheap and generic. Why would Pharma spend money on something that they can't patent?

Same issue with psychedelics. However, they are so useful that people in the medical/therapeutic/academic fields are doing tons of research anyway.

Apparently big pharma is also trying to create their own psychedelics (there was an article about it on the front page of HN recently).

So far, the business seems like it will be on the assisted therapy side and everything that it entails. So more like services instead of products.

Post reply on HN