151–160 of 170 posts
They're conducting a Phase II trial now with 85 participants, the completion date is set to November 2022. https://clinicaltrials.gov/ct2/show/NCT04375657
Epigenetics is fascinating. I just came back from a project meeting, where i work with people who discovered that HRT (hormone replacement therapy) slows down epithelial cell aging. Epithelial cells are the cells that cover all your vital organs, so they are important for aging. Now, there are even commercial companies that measure Epigenetic age of cells with a technique called DNA methylation. References: https://i…
DNA methylation is not a technique that can be applied. It is a biological system present in your cells silencing expression of genes that are not useful for a cells current behavior. Differently differentiated cells have different "genes methylated" and thus inactivated which govern their behavior and potential for further sub-differentiation. Indiscriminately "reversing methylation" would probably lead to a lot of…
What are the 3 ingredients? HGH, possibly metformin and what else? The article does not clearly state.
DHEA, Metformin and HGH. My personal preference is to replace Metformin with Berberine since I can get it online or grow it in a greenhouse and it is less likely to induce lactic acidosis. One can fast for 72+ hours to get a massive spike in HGH. I am not a doctor and this is not medical advice. I also consume desiccated Thymus in capsule form following the "like improves like" theories. Here is a video discussing th…
Are you seeing results? And does it improve healing (skin and knee injuries here) ?
Earlier quoted context omitted.
DNA methylation is not a technique that can be applied. It is a biological system present in your cells silencing expression of genes that are not useful for a cells current behavior. Differently differentiated cells have different "genes methylated" and thus inactivated which govern their behavior and potential for further sub-differentiation. Indiscriminately "reversing methylation" would probably lead to a lot of…
You don't apply DNA methylation - it is the basis for measuring epigenetic age. I mentioned HRT as one way of reducing epigenetic age for epithelial cells.
The reference you gave measure blood or urine samples which would probably not be representative of epithelial cells. Also i like non-descriptive but professional looking stock photos of multi-pipettes and the ubiquitus vortex genie 2. Extra points for consecutive photos of the same tip-rack in obviously proffessional use.
Earlier quoted context omitted.
DHEA, Metformin and HGH. My personal preference is to replace Metformin with Berberine since I can get it online or grow it in a greenhouse and it is less likely to induce lactic acidosis. One can fast for 72+ hours to get a massive spike in HGH. I am not a doctor and this is not medical advice. I also consume desiccated Thymus in capsule form following the "like improves like" theories. Here is a video discussing th…
Thank you. Are you seeing results? And does it improve healing (skin and knee injuries here) ?
I'll be happy if two things happen: 1. I can have "better years" in the same lifespan. Lots of energy at 90 for instance. 2. I can increase the lifespan of my dog by 50 years :)
Earlier quoted context omitted.
I think both approaches are amazing advancement for humanity, and I wish Greg Fahy would get more funding as well. Before Jeff Bezos came in, the money was really really missing from the longevity field that I have been following for the last 10 years since I've got a serious rare, but not deadly cronic illness. Maybe I've got a bit sad when you refered money as not the most important thing, because Gregory Fahy said…
It is not just money, but liberation of creative people from the bureaucracy and limitations that come with the public grant system. AFAIK the professors in Altos Labs get a million dollars yearly salary and they are free to dig into whatever matter they find interesting, as long as it is somehow related to biology of aging, rejuvenation, regeneration etc. No need to stay within relatively narrow limits of an approve…
I'd love them to be more public about their plans. mRNA / viral delivery needs to be optimized of course, but there are lots of other parallel experiments they can start, and we probably have to wait for the publications.
For anyone interested in the topic, I'd encourage reading "Lifespan" by David A. Sinclair. As someone with little to no-knowledge about aging (other than feeling the effects of aging on myself) I found it very instructive on how our aging clock works and what are some of the ongoing studies to slow down or revert aging.