Antiplatelet and anticoagulant therapy resolves long covid in 24 patients • Hacker News Board

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#151

Post by aarongray » Wed, Jan 05, 2022, 7:26 PM UTC

myoldohiohome wrote: post #50

jokethrowaway wrote: post #37

Sounds exactly like chronic fatigue syndrome, I don't know why we keep calling it Long COVID while we have a name for it. https://www.nhs.uk/conditions/chronic-fatigue-syndrome-cfs/ > Suggested causes or triggers for ME/CFS include: > viral infections, such as glandular fever > bacterial infections, such as pneumonia > problems with the immune system > a hormone imbalance > your genes – ME/CFS seems to be more common…

I hope so too. I recognized the symptoms (in myself) as soon as I started reading the abstract. --- from the link cdrini posted above, which is a Guardian article by one of the authors of the study in the original post.[0] "Even those without long Covid could benefit from such research, as symptoms noted in long Covid patients show many similarities to those seen in chronic and viral-related illnesses including myalg…

If you're interested in Biomarkers for Long Covid and ME/CFS, look up Chronic Inflammatory Response Syndrome (CIRS). MMP-9, MSH, ACTH, TGF-beta 1, Cortisol, Glutathione, and Vasoactive Intestinal Peptide are a few of them. Lots of research here that was started by illnesses triggered by mold mycotoxins and lyme disease - the initial trigger is different than Covid - but the end result in terms of biomarkers and dysregulation in the body is the same. Doctors have been using these protocols to successfully treat patients for a few years now, but it just hasn't trickled down to the mainstream medical community or the medical schools yet.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#152

Post by swader999 » Wed, Jan 05, 2022, 7:27 PM UTC

manwe150 wrote: post #145

swader999 wrote: post #94

Earlier quoted context omitted.

Yes! And I think it's fair to assume that the vaccine spike can distribute widely throughout your body. Long covid and a subset of vaccine injury cases are very hard to distinguish. They present the same symptoms.

Why? We can hypothesize anything, but we shouldn’t just assume everything. The manufacturers made changes to the RNA sequence to reduce the ability to leave the cell, and then tested it in animal studies to confirm.

As OP indicates, it can still bind to ACE-2 and that changes the way these cells behave. Peristalsis in your veins is changed when the endothelial cells which have ACE2 are hit with spike (vaccine origin or covid origin) for instance.

I think there's enough evidence out there that spike from vaccines circulate widely. I can dig it up if you want?

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#153

Post by ciphol » Wed, Jan 05, 2022, 7:31 PM UTC

nradov wrote: post #65

imnotreallynew wrote: post #58

It was my understanding that the existence of “long covid” is still debated as there hasn’t been any real evidence for it other than patient anecdotes.

Most any serious viral infection can potentially cause post-viral fatigue syndrome. We've known that for decades and COVID-19 is nothing special in that regard. https://pubmed.ncbi.nlm.nih.gov/3063394/ But many cases of "long covid" appear to be psychosomatic. https://jamanetwork.com/journals/jamainternalmedicine/fullar...

And that's why this result is exciting - not only is it promising for long covid, but also for post-viral fatigue syndrome and chronic fatigue syndrome.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#154

Post by [deleted] » Wed, Jan 05, 2022, 7:32 PM UTC

swader999 wrote: post #105

yuubi wrote: post #98

Earlier quoted context omitted.

Is this the FLCCC that pushes ivermectin (a fine worm killer, but no panacea) for covid?

Ivermectin has many modes of action. It's been recognized as a potent anti viral long before covid. For instance, see Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus. Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug. A screen of FDA-approved drugs for i…

[deleted]

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#155

Post by swader999 » Wed, Jan 05, 2022, 7:32 PM UTC

jrussino wrote: post #150

hammock wrote: post #120

Earlier quoted context omitted.

If anyone is interested in the data available on ivermectin for COVID, and whether it works, you can find a lot of it here: https://c19ivermectin.com/

I found Scott Alexander's review to be very informative: https://astralcodexten.substack.com/p/ivermectin-much-more-t...

I read all that a while back. It is good and about all you can get out of it is to conclude that ivermectin needs more study. Unfortunately its off patent and won't get much $$$ thrown at it. Its getting hard to ignore the growing mass of people that have just said, hey, this is obviously safe and I'll just try it. And holy sh-t it worked! (that's my story...).

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#156

Post by ciphol » Wed, Jan 05, 2022, 7:32 PM UTC

swayvil wrote: post #25

Could covid not actually be just a disease? Maybe it's a disease + chronic unhealth. Due to age, pollution, obesity, bad diet, sitting on yr butt too much and/or etc

Nearly all diseases are worse if you're in bad health to begin with. That doesn't make them "not just diseases".

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#157

Post by henrikschroder » Wed, Jan 05, 2022, 7:33 PM UTC

nradov wrote: post #65

imnotreallynew wrote: post #58

It was my understanding that the existence of “long covid” is still debated as there hasn’t been any real evidence for it other than patient anecdotes.

Most any serious viral infection can potentially cause post-viral fatigue syndrome. We've known that for decades and COVID-19 is nothing special in that regard. https://pubmed.ncbi.nlm.nih.gov/3063394/ But many cases of "long covid" appear to be psychosomatic. https://jamanetwork.com/journals/jamainternalmedicine/fullar...

An old friend of mine has long covid, the real deal, but she was also sick in covid for months in 2020. What she has matches post-viral fatigue syndrome perfectly, and she's getting care for it, from realistic doctors who've been saying that recovery is gonna be slow but steady. She's better now, a year later.

And then, just as you say, there's "long covid", which is a large number of people who have very generic ailments, and if you start digging into the numbers, you realize it's all self-reported bullshit, where a good chunk of the sufferers haven't even been diagnosed with covid in the first place! Their symptoms match depression very well, though.

It's extremely frustrating watching people like my friend getting ridiculed for having an imaginary disease. She doesn't. And at the same time it's even more frustrating watching a relatively huge number of psychosomatic hypochondriacs getting all the attention and using up the wrong kind of healthcare resources, just because a lot of people are using long covid for generating fear porn and want it to be worse than it is.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#158

Post by mikeyouse » Wed, Jan 05, 2022, 7:37 PM UTC

TechBro8615 wrote: post #142

mikeyouse wrote: post #114

Earlier quoted context omitted.

You'd be more informed (less uninformed in reality) reading a tabloid about bigfoot on the moon than whatever the hell that is.

Do you have any substantive critique to offer of the various lemmas established throughout the piece, which refers to itself as “an argument and petition for plurality under Ockham’s Razor?” Or do you rely solely on appeals to authority when filtering signal from noise? I’ve noticed throughout this pandemic that many arguments supported on such a weak basis have later been disproven or severely undercut by further ev…

Are there any conspiracy theories you don't believe or do you just assume they're all equally plausible?

It's a workday and I'm busy but I'll grant you one substantive critique; the OP heavily relies on "mutations per year" as a metric to derive how plausible it is that something like Omicron could have mutated in the timeframe necessary.

Does it strike you as a bit suspect to rely on a mutations/time period, and completely ignore the number of infections? It should. The rate of mutations/year is a useful metric for determining the average mutation rate between two different viruses given certainty of their dates -- it's not at all useful for "aging" a specific variant because the calculation is independent of the number of infections.

We're in the midst of a pandemic with hundreds of millions of infections, so the selection pressure for more "fit" viruses is immense. OP tries to get around this by claiming that the rate of mutation that we've actually measured (which is an order of magnitude higher than his assumption!) is suspect and would "extinguish SARS COV2 within a season" but that's just gibberish.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#159

Post by kadoban » Wed, Jan 05, 2022, 7:43 PM UTC

yamrzou wrote: post #110

nradov wrote: post #88

Earlier quoted context omitted.

That's not strictly true. Consider our complete set of medical knowledge today. What percentage of that knowledge came from studies with control groups?

When experimenting with new treatments, a control group is very important. Otherwise the study could be biased in favor or against the treatment. Even when a control group is present, a poorly-designed experiment could later turn out to be problematic, such as the Diethylstilbestrol (DES) medical tragedy ( https://en.wikipedia.org/wiki/Diethylstilbestrol ). In that case, studies that were in favor of the treatment we…

I suspect nobody would argue that lack of a control group is better, but this should still be a good lead for something to look at more deeply. It's not like it gives you no information.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#160

Post by randcraw » Wed, Jan 05, 2022, 7:58 PM UTC

JohnJamesRambo wrote: post #5

I think I’m going to start taking aspirin. Oddly enough I took that a few times because I didn’t have ibuprofen and I do feel like it helped a lot with the weird long symptoms I am experiencing. I’m triple vaccinated before anyone asks. I haven’t tested positive for Covid on rapid tests but a lot of people seem to be in the boat I’m in right now.

80 mg/day aspirin generally has been shown to be safe long term, though it does increase irritation of the stomach. Maybe taking it with food will help that.

I would absolutely NOT do the same with ibuprofen or any other NSAID. All other NSAIDs but aspirin have been shown to reduce blood vessel elasticity after habitual use. Adopting any med for regular use is not something to take lightly.

"Ibuprofen, aspirin, and COX-2s all belong to the class of medicines called nonsteroidal anti-inflammatory drugs (NSAIDs). Most of them boost blood pressure and can counteract the effect of some blood-pressure drugs. They can also impair blood vessels' ability to relax and may stimulate the growth of smooth muscle cells inside arteries. All these changes can contribute to the artery-clogging process known as atherosclerosis."

https://www.health.harvard.edu/press_releases/nsaid-side-eff...