Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

Post by robomartin » Sat, Aug 21, 2021, 10:42 PM UTC

dang wrote: post #149

robomartin wrote: post #146

I don't know how young you are. Great story, but, sorry, no. Every single weight loss program claims exactly what you claim. And they all deliver pretty much exactly the same results. My guess is that about 10 to 20 percent of weight loss program participants achieve sustainable life-long objectives, keep the weight off and change their lifestyle. The rest are in a range between utter failure and yo-yo diet programs…

Please stop posting these rants. Hounding someone like this after you already personally attacked them is crossing into harassment. I already asked you to stop once, and you've responded by doing more of it, not once but twice. Seriously not cool. We detached this comment from https://news.ycombinator.com/item?id=28258175 .

Post by rich-cartwright » Sat, Aug 21, 2021, 10:57 PM UTC

bserge wrote: post #142

jimmaswell wrote: post #37

Earlier quoted context omitted.

> basically the body fights hard against you as you try to lose weight by dieting. I used to weigh 310lbs, now I'm 215lbs. All I did was count calories to maintain a deficit and the results were essentially the same as predicted by the math. I was a bit hungry sometimes at first as I adjusted to it but that's really it. Prioritizing protein and fat over carbs helps with that. What ways does the body tend to fight aga…

Extreme hunger, like others said. I'd class it as a subset of impulsive behavior, which is basically your primitive brain doing it's caveman shit and not listening to you , the conscious mind. Apparently some people don't have this problem, which makes me incredibly envious (or would if I could feel anything). It's this nagging thought of "JESUS CHRIST YOU'RE GONNA DIE IF YOU DON'T EAT A LOT RIGHT NOW!" I've experien…

Post by rubicon33 » Sat, Aug 21, 2021, 11:02 PM UTC

bserge wrote: post #142

jimmaswell wrote: post #37

Earlier quoted context omitted.

> basically the body fights hard against you as you try to lose weight by dieting. I used to weigh 310lbs, now I'm 215lbs. All I did was count calories to maintain a deficit and the results were essentially the same as predicted by the math. I was a bit hungry sometimes at first as I adjusted to it but that's really it. Prioritizing protein and fat over carbs helps with that. What ways does the body tend to fight aga…

Extreme hunger, like others said. I'd class it as a subset of impulsive behavior, which is basically your primitive brain doing it's caveman shit and not listening to you , the conscious mind. Apparently some people don't have this problem, which makes me incredibly envious (or would if I could feel anything). It's this nagging thought of "JESUS CHRIST YOU'RE GONNA DIE IF YOU DON'T EAT A LOT RIGHT NOW!" I've experien…

Post by rich-cartwright » Sat, Aug 21, 2021, 11:06 PM UTC

watwut wrote: post #138

dlevine wrote: post #95

I have done just about everything over the years to lose weight. I tend to exercise a ton naturally, so it has been more about eating less than exercising more. I would say that my natural weight is slightly overweight but not obese. I've tried various brands of keto (Atkins/4 Hour Body), Weight Watchers, eating slowly, cutting out sugar and wheat, juice fasts. Everything has worked for a time, but the weight has eve…

Is it possible that you are at healthy weight for you? Because given lifestyle you described, it is quite possible.

Post by rich-cartwright » Sat, Aug 21, 2021, 11:21 PM UTC

gnicholas wrote: post #132

lharries wrote: post #129

Earlier quoted context omitted.

(Richie's co-founder here) Semaglutide was FDA approved for diabetes in 2018 (3 years ago) and in June this year for weight management. It's part of a class of medication called GLP-1 RAs which operate in a similar way (they all stimulate the same GLP-1 receptor). Liraglutide is another common one that was approved by the FDA in 2010 (11 years ago) for diabetes (by the EU in 2009) and for weight management in 2014. S…

Thanks for your candor. It would be interesting to see what positive effects can be achieved for what types of patients at various different dosing levels. I'm not at a weight where I'd want to add additional cancer risk in order to lose weight, and unfortunately the data on this sort of incremental risk probably takes decades to be fully realized. Perhaps I'd feel comfortable taking a smaller dose if there were a sh…