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Evaluating necessity of Covid-19 vaccination in previously infected individuals

medrxiv.org

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Re: Evaluating necessity of Covid-19 vaccination in previously infected individuals

#151

Post by ardomation »

waterside81 wrote: post #70
stavros wrote: post #28

Earlier quoted context omitted.

That's encouraging! I got COVID a few months ago and got vaccinated recently, seems like I should be unstoppable now.

Hey I'm curious, if you don't mind sharing, how do you think you got it? Throughout this whole pandemic, I'm still kind of amazed how people are getting it

My wife got it either at the grocery store or Home Depot early in. She’s a nurse and worked with covid patients but hadn’t been to work for over two weeks. Those were the only places we had gone otherwise. I got it from her a few days after she showed symptoms.

Re: Evaluating necessity of Covid-19 vaccination in previously infected individuals

#152

Post by sickcodebruh »

waterside81 wrote: post #70
stavros wrote: post #28

Earlier quoted context omitted.

That's encouraging! I got COVID a few months ago and got vaccinated recently, seems like I should be unstoppable now.

Hey I'm curious, if you don't mind sharing, how do you think you got it? Throughout this whole pandemic, I'm still kind of amazed how people are getting it

My wife and I think we got it from movers in NYC. We had become too comfortable around others and overly confident that we wouldn’t get it. I was diagnosed two weeks before my vaccine appointment, it was so frustrating to fail so close to the finish line!

Re: Evaluating necessity of Covid-19 vaccination in previously infected individuals

#153

Post by rayiner »

waterside81 wrote: post #70
stavros wrote: post #28

Earlier quoted context omitted.

That's encouraging! I got COVID a few months ago and got vaccinated recently, seems like I should be unstoppable now.

Hey I'm curious, if you don't mind sharing, how do you think you got it? Throughout this whole pandemic, I'm still kind of amazed how people are getting it

Yeah it’s great to be one of the minority of people who are able to work from home and do Amazon delivery for their meals!

Re: Evaluating necessity of Covid-19 vaccination in previously infected individuals

#154

Post by rayiner »

hn_throwaway_99 wrote: post #150
briefcomment wrote: post #96

Earlier quoted context omitted.

Most authorities are downplaying natural immunity, despite evidence like this. The more widely this spreads, the more people will realize it's ok to rely on natural immunity, and to not blanket demonize those who are unvaccinated.

> Most authorities are downplaying natural immunity, despite evidence like this. OK, I think I can agree with this, I've seen lots of "getting the vaccine provides much better immunity than getting Covid"-type statements that seemed more like conjecture. > The more widely this spreads, the more people will realize it's ok to rely on natural immunity, and to not blanket demonize those who are unvaccinated. Is this a s…

It rarely results in death. Even men 65-75 have a only a 3% chance of dying if they get covid. To put that into perspective, according to the mortality tables, those people have a 1.5-3.5% chance of dying in a given year even under normal circumstances.

Re: Evaluating necessity of Covid-19 vaccination in previously infected individuals

#155

Post by josephcsible »

starfallg wrote: post #80
variaga wrote: post #17

Earlier quoted context omitted.

The rough theory - as I understand it - is that the virus is composed of other things as well as the spike protein e.g. the proteins in the viral shell. The immune system can learn to attack _whatever_ foreign materials it encounters. So a person that clears the infection might have a strong immune response to the spike protein, but the response could also be focused on some other part of the virus (or a mixture of d…

A 2-dose vaccination regime (separated by 8-12 weeks) also gives our immune system time to build up the spike protein. An actual infection doesn't last as long and hence our immune system doesn't process it in the same way.

> separated by 8-12 weeks

Who's doing that? Isn't the separation 3 weeks for Pfizer and 4 for Moderna?

Re: Evaluating necessity of Covid-19 vaccination in previously infected individuals

#156

Post by cstejerean »

bobthechef wrote: post #140
SkyPuncher wrote: post #127

Earlier quoted context omitted.

> to not blanket demonize those who are unvaccinated. Well, I'm currently in quarantine from my 4 month old and wife because an acquaintance refused to get vaccinated. "young people don't die from COVID" type mentality. I attended my brother's bachelor party - of which we all thought everyone was vaccinated. Turns out this person, not only refused to get vaccinated - but had COVID exposure and still decided to attend…

> "young people don't die from COVID" type mentality. What mentality is this? It is well known that young people are at extremely low risk of dying, even more so than the average person. > He told us the day after being in close contact for 3 days, that he tested positive and had symptoms during our contact with him. The problem wasn't that your acquaintance refused the vaccine. The problem is that he didn't stay hom…

> There's also evidence that asymptomatic people don't spread COVID. This would mean that if they don't have symptoms, you won't get it, and if they do and they're like most people, they'll stay home which means no transmission.

We wouldn’t be in the middle of a pandemic if this were true.

Re: Evaluating necessity of Covid-19 vaccination in previously infected individuals

#157

Post by JeremyNT »

hn_throwaway_99 wrote: post #150
briefcomment wrote: post #96

Earlier quoted context omitted.

Most authorities are downplaying natural immunity, despite evidence like this. The more widely this spreads, the more people will realize it's ok to rely on natural immunity, and to not blanket demonize those who are unvaccinated.

> Most authorities are downplaying natural immunity, despite evidence like this. OK, I think I can agree with this, I've seen lots of "getting the vaccine provides much better immunity than getting Covid"-type statements that seemed more like conjecture. > The more widely this spreads, the more people will realize it's ok to rely on natural immunity, and to not blanket demonize those who are unvaccinated. Is this a s…

> > The more widely this spreads, the more people will realize it's ok to rely on natural immunity, and to not blanket demonize those who are unvaccinated.

> Is this a serious statement? The problem isn't that natural immunity doesn't keep make you immune, the problem is that "acquiring natural immunity" often results in death, especially for vulnerable populations.

It's a real policy question: how much to worry about vaccinating people who already had COVID. The confusion (or propaganda?) downplaying natural immunity means that many people would needlessly get the vaccine while already possessing immunity from prior infection.

In the US, this no longer matters, as we already have more vaccine supply than we have people willing to receive it. Elsewhere, though, where supplies remain scarce, we absolutely should be focusing efforts around vaccinating people who have not yet gotten the disease.

Re: Evaluating necessity of Covid-19 vaccination in previously infected individuals

#158

Post by briefcomment »

hn_throwaway_99 wrote: post #150
briefcomment wrote: post #96

Earlier quoted context omitted.

Most authorities are downplaying natural immunity, despite evidence like this. The more widely this spreads, the more people will realize it's ok to rely on natural immunity, and to not blanket demonize those who are unvaccinated.

> Most authorities are downplaying natural immunity, despite evidence like this. OK, I think I can agree with this, I've seen lots of "getting the vaccine provides much better immunity than getting Covid"-type statements that seemed more like conjecture. > The more widely this spreads, the more people will realize it's ok to rely on natural immunity, and to not blanket demonize those who are unvaccinated. Is this a s…

> the problem is that "acquiring natural immunity" often results in death, especially for vulnerable populations

You're reading beyond what I'm saying. My point is that there is no need to push those who have already gotten Covid to also get the vaccine. I'm not saying anything about getting sick as an alternative to getting the vaccine.

Re: Evaluating necessity of Covid-19 vaccination in previously infected individuals

#159

Post by kbutler »

waterside81 wrote: post #70
stavros wrote: post #28

Earlier quoted context omitted.

That's encouraging! I got COVID a few months ago and got vaccinated recently, seems like I should be unstoppable now.

Hey I'm curious, if you don't mind sharing, how do you think you got it? Throughout this whole pandemic, I'm still kind of amazed how people are getting it

Son presumably got it at school (high mask compliance). Wife presumably got it from son. 5 days before other son's wedding...

Re: Evaluating necessity of Covid-19 vaccination in previously infected individuals

#160

Post by mlyle »

josephcsible wrote: post #155
starfallg wrote: post #80

Earlier quoted context omitted.

A 2-dose vaccination regime (separated by 8-12 weeks) also gives our immune system time to build up the spike protein. An actual infection doesn't last as long and hence our immune system doesn't process it in the same way.

> separated by 8-12 weeks Who's doing that? Isn't the separation 3 weeks for Pfizer and 4 for Moderna?

Canada/the UK have been doing that.

Odds are it does make things more effective rather than less, based on our experience with other vaccines. But IMO it's not wise, because it wasn't studied.

Still, 2 huge peaks separated by 3-4 weeks provokes really big immune responses.

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