Do you mean interested in
something or interested in
a specific topic?
If you’re not curious about the world in general, then I’m not sure anything can change that trajectory, although I could be wrong.
For a specific topic, I recommend learning about that topic from someone who is passionate about it and who is a good teacher.
Sometimes this can be as easy as reading books by a good author. When I was in high school, I despised history. It turns out that I despised it because I had never been exposed to compelling history. I ended up becoming friends with someone who was a passionate historian, and he pointed me to compelling resources that totally changed my mind about history.
In college, I had no interest in art or art classes. A friend of mine took a drawing class that she said “blew her mind”. I couldn’t believe it, but she just told me to trust her and take the class. I asked a few other people, and they all said the same thing. I took the class, and they were all correct. While the topic was technically drawing, the professor pushed us to explore what our drawing told us about ourselves, how we could expand our minds through drawing, and how our drawing related to our interactions with the world. Just re-reading that, it sounds like hippy-dippy bullshit, but to experience it was something else, and it is something most participants in that class took away in a positive way.
I ended up minoring in art, and I worked with another professor who really stretched my mind.
While these are my personal experiences (and there are many more that I didn’t mention), I think I have seen this pattern amongst my friends and acquaintances as well. As such, I recommend finding a good, highly recommended, talented teacher if you want to get interested in a new topic. Note that they are not always easy to find.