Yesterday my goal was to live 150 years. I am expanding it to 250 now :D
We will be able to live to 1,000
151–156 of 156 posts
Re: We will be able to live to 1,000
#152Earlier quoted context omitted.
Before donating you should ask yourself whether Aubrey de Grey is a crackpot or not. I'm not sure myself. Can somebody shed some light on this?
That's complicated. My criticism of Aubrey de Grey is one I have of transhumanism in general, which is that it's mostly CS people taking Moore's law and applying it to biological problems without having any experience in biology. Aubrey de Grey's degrees are not in the life sciences, and to my knowledge he's never been directly engaged in a biological research project. Those of us who have done aging research underst…
In my opinion conquering aging is pretty much the same a beating any other disease albeit aging is a complex issue involving many different processes. What is comes down to is the realization that there is no magic bullet and that it is a case of chipping away at the root causes and making progress incrementally until we have them all brought to a position where they are manageable. Aging is no different to any other process and we are starting to understand the root causes and the changes which arise as the body ages. I agree that Aubrey makes it sound simpler than it actually is by breaking the causes down to seven factors as set out below but that does not mean that it is not a realistic proposition to render aging a treatable although chronic condition within 25 to 30 years! The key is funding and for more on that check out http://www.methuselahfoundation.org/
As Aubrey points out we have already discovered the seven biochemical processes which are the root cause of aging. The first was discovered in the mid 1950s, the last almost 30 years ago in 1981. The importance of the amount of time that has elapsed since the discovery of the last of the seven is that it took less time to discover the entire list than has passed since and nothing else has been found. Now factor in the massive increase in our knowledge of biology that has taken place over that time and it seems virtually certain that these seven causes are all there are - cure those and you cure aging! The following is the list with potential solutions some of which are either confirmed or where progress is already at an advanced stage.
1. Cell death and atrophy: Treatable with exercise, stem cells, and chemicals which stimulate cell division.
2. Cancerous cells: Theoretically treatable with a type of gene therapy being developed, called Whole Body Interdiction of Lengthening of Telomeres (WILT).
3. Mutant mitochondria: Mutated DNA in the mitochondria causes a number of diseases. These can be prevented by moving the mitochondrial DNA into the cell nucleus, where the rest of the DNA resides.
4. Cell senescence (unwanted cells): Fat cells and other unwanted cruft can be removed surgically, or by stimulating the immune system to attack unwanted cells.
5. Extracellular crosslinks (loss of elasticity): Certain proteins, such as those in cells making up the arteries, become too rigid over time because they bond to each other. These bonds can be broken with certain chemicals (some in clinical trials even today).
6 Extracellular junk: “Plaque” which collects between cells can be eliminated by stimulating the immune system, and/or by using peptides called “beta-breakers.”
7. Intracellular junk: Molecular garbage can be prevented from overwhelming certain cells by introducing enzymes which are known to be effective against such molecules.
In my opinion aging is no different to any other disease and like all diseases aging is ultimately treatable given the requisite technology. We cannot afford to sit back and simply accept that because everyone in history has lived and died we must follow the same patch. It is a mistake to view aging as a fact of life set in stone when science has progressed to the level where we have the ability to begin the search for a cure. We might not be there yet but we are within striking distance of adding 20 or 30 years to our life expectancy and as Aubrey himself points out increases in life expectancy will be incremental and there is not going to be a sudden magic pill which you take and live forever. The essence of the engineering approach advocated by Aubrey is to manage aging, what he proposes is not a cure but a case of repairing the damage that occurs as we age at various intervals and not to stop the process but to allow the aging process to continue and repair the damage as it arises in the same way you maintain a house or car. This engineering approach is a case of taking advantage of improvements in technology as they occur and not to attempt to cure aging in its entirety and it is in this area that people fail to grasp what Aubrey de Grey is seeking to achieve. I recommend the two books below as great reading and all will be revealed!
Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime (Aubrey de Grey and Michael Rae) ISBN-10: 0312367066 ISBN-13: 978-0312367060
Transcend: Nine Steps to Living Well Forever (Ray Kurzweil and Terry Grossman MD) ISBN-10: 1605299561
I would also check out the following regarding Aubrey de Grey http://www.citywire.co.uk/personal/-/retirement/news-and-fea...
and also the following about Ray Kurzweil if this lot does not wet your appetite for joining the war on aging nothing will!
Re: We will be able to live to 1,000
#153Earlier quoted context omitted.
Aging certainly is a natural process. So is Aids. I always assumed that a disease can be both and most of time is both. I don’t even know whether it makes sense to define disease with the help of a term like “natural”. I would define a disease as something which harms people (i.e. curtailing their cognitive or physical abilities) or kills them. Then I exclude a bunch of stuff which has traditionally not been called d…
Well, unless you exclude it, and it's pretty biased not to. I think you need a better definition. 1913 Webster has: 1. Lack of ease 2. An alteration in the state of the body or of some of its organs, interrupting or disturbing the performance of the vital functions, and causing or threatening pain and weakness Now that does fit aging.
Yeah, my definition is not that great, should have thought more about that.
Re: We will be able to live to 1,000
#154Earlier quoted context omitted.
I understand you might not want to live that long, but why would you want to take that away from others?
Because the world is already overpopulated and we don't currently have any means to spread our virus to a different planet.
So your solution to alleviate potential suffering is to induce immediate suffering?
Re: We will be able to live to 1,000
#155Re: We will be able to live to 1,000
#156Earlier quoted context omitted.
Before donating you should ask yourself whether Aubrey de Grey is a crackpot or not. I'm not sure myself. Can somebody shed some light on this?
He's looking for cures to issues that are real problems. If you fix any of the problems, even partially, they show great promise for helping older people to be decrepit, even if they don't actually extend lifespan. His hope is curing these types of damage will cause humans to functionally stop aging, but curing these types of damage are useful in and of themselves : Cell loss, tissue atrophy Nuclear [epi]mutations Mu…
In some areas we are making rapid progress on some rather less but solutions are know to all 7 causes of aging as outlined below.
1. Cell death and atrophy: Treatable with exercise, stem cells, and chemicals which stimulate cell division.
2. Cancerous cells: Theoretically treatable with a type of gene therapy being developed, called Whole Body Interdiction of Lengthening of Telomeres (WILT).
3. Mutant mitochondria: Mutated DNA in the mitochondria causes a number of diseases. These can be prevented by moving the mitochondrial DNA into the cell nucleus, where the rest of the DNA resides.
4. Death Resistant Cells or Cell senescence (unwanted cells): Fat cells and other unwanted cruft can be removed surgically, or by stimulating the immune system to attack unwanted cells.
5. Tissue stiffening or Extracellular crosslinks (loss of elasticity): Certain proteins, such as those in cells making up the arteries, become too rigid over time because they bond to each other. These bonds can be broken with certain chemicals (some in clinical trials even today).
6 Extracellular aggregates or junk: “Plaque” which collects between cells can be eliminated by stimulating the immune system, and/or by using peptides called “beta-breakers.”
7. Intracellular aggregates or junk: Molecular garbage can be prevented from overwhelming certain cells by introducing enzymes which are known to be effective against such molecules.
In my opinion aging is no different to any other disease and like all diseases aging is ultimately treatable given the requisite technology. We cannot afford to sit back and simply accept that because everyone in history has lived and died we must follow the same path. It is a mistake to view aging as a fact of life set in stone when science has progressed to the level where we have the ability to begin the search for a cure. We might not be there yet but we are within striking distance of adding 20 or 30 years to our life expectancy and as Aubrey himself points out increases in life expectancy will be incremental and there is not going to be a sudden magic pill which you take and live forever. The essence of the engineering approach advocated by Aubrey is to manage aging, what he proposes is not a cure but a case of repairing the damage that occurs as we age at various intervals and not to stop the process but to allow the aging process to continue and repair the damage as it arises in the same way you maintain a house or car. This engineering approach is a case of taking advantage of improvements in technology as they occur and not to attempt to cure aging in its entirety and it is in this area that people fail to grasp what Aubrey de Grey is seeking to achieve. I recommend the two books below as great reading and all will be revealed!
Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime (Aubrey de Grey and Michael Rae) ISBN-10: 0312367066 ISBN-13: 978-0312367060
Transcend: Nine Steps to Living Well Forever (Ray Kurzweil and Terry Grossman MD) ISBN-10: 1605299561
I would also check out the following regarding Aubrey de Grey http://www.citywire.co.uk/personal/-/retirement/news-and-fea...
and also the following about Ray Kurzweil if this lot does not wet your appetite for joining the war on aging nothing will!