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Semaglutide linked to lower predicted dementia risk

alz-journals.onlinelibrary.wiley.com

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Re: Semaglutide linked to lower predicted dementia risk

#141

Post by mathgeek »

loeg wrote: post #121
kccqzy wrote: post #92

Earlier quoted context omitted.

I’m also active and fat. And to me being active is more important than losing weight; I’d rather continue to do those long 2000kcal bike rides on weekends than having a healthier BMI. I’ve heard stories of my own friends bonking during a ride and I decided that I wanted to err on the side of overeating. So semaglutide doesn’t interest me. You aren’t the only one I’ve heard who started to have no energy after being on…

I'm on tirzepatide, a competitive athlete, and have no idea what GP is talking about.

People who eat well below their maintenance calories tend to have lower energy levels. That's the most likely explanation.

Re: Semaglutide linked to lower predicted dementia risk

#142

Post by overgard »

Some researchers have (informally) taken to calling certain forms of dementia "type-3 diabetes", so I think this sounds at least plausible. It's far from a foregone conclusion or anything, but there's at least some evidence that dementia might be a metabolic issue, so it would make sense that something that improves metabolic health would also improve brain health.

Re: Semaglutide linked to lower predicted dementia risk

#144

Post by paulpauper »

fkdupman wrote: post #131

Reading about GLP-1 medications reminds me of the movie Limitless. Being on them sounds great, getting off of them not so much.

not really. these drugs only merely make you not overweight or obese, which was normal until around 1980 or so.

Re: Semaglutide linked to lower predicted dementia risk

#145

Post by paulpauper »

kccqzy wrote: post #92
01100011 wrote: post #38

I'm a big semaglutide proponent after being on it for a year. I know research says it helps with inflammation, arthritis (separately from weight reduction), and all sorts of magical things. I lost 40 pounds in a year(230 to 190) at age 50. Great! I also went from being active and fat(weightlifting with some cardio) to basically having no energy. In the last year I've had arthritis appear in several joints. I'm awake…

I’m also active and fat. And to me being active is more important than losing weight; I’d rather continue to do those long 2000kcal bike rides on weekends than having a healthier BMI. I’ve heard stories of my own friends bonking during a ride and I decided that I wanted to err on the side of overeating. So semaglutide doesn’t interest me. You aren’t the only one I’ve heard who started to have no energy after being on…

There are so many active overweight or obese guys, whether it's cycling, swimming or hiking .This myth that inactivity = obesity or that activity fixes obesity or being overweight, need to die. It's not that simple. Hunger signals and how the body partitions/uses food is only orthogonal to activity.

Re: Semaglutide linked to lower predicted dementia risk

#146

Post by pessimizer »

This is one of those fake stats, where

if among people not taking it you would see 4 out of 100 get dementia within 5 years of when you started measuring,

if they were taking it you'd instead see 3 out of 100 get dementia within 5 years,

and the number is either a projection ("predicted risk") because they didn't actually study it for 5 years,

or the number is a p-hack because they checked every possible thing they could with the 5-year data they had and this was the only interesting thing that they found ("post hoc analysis"),

or both (the projection of a p-hack), which I suspect because they also tell you about the 20-year risk,

and it is a study sponsored by the manufacturers of the drug,

being suggested to cure a disease diagnosed by checklist (rather than any physical test.)

Will that keep it out of the headlines? No, it was written to become a "free" ad that will be published by the people they send enormous amounts of money to, but by their "news" departments.

The best thing we can do for the progress of medicine in the US is to make direct-to-consumer advertising of prescription drugs illegal again. There would be no use for this if the media hadn't been bribed to become cheerleaders for any old shit. It's illegal everywhere in the world other than the US and New Zealand.

Re: Semaglutide linked to lower predicted dementia risk

#147

Post by tacon »

brokensegue wrote: post #103
to11mtm wrote: post #97

Earlier quoted context omitted.

And have a real conversation around Corn syrup. Even today, a Soda with 'real sugar', at least for me, is far more satiating for thirst or a 'quick sweet treat' than the same brand/'flavor' using corn syrup, that includes both the big chains as well as the local names. If I drink a soda with sugar in it, I usually wind up wanting water after. If I drink something with corn syrup, I usually just want more of whatever…

Is there evidence supporting the idea that sugar is more satiating? My understanding was that they were equally unhealthy

No, the evidence is that there is no significant difference in satiety. HFCS is 55% fructose / 45% glucose, while sucrose is 50% fructose / 50% glucose.

Re: Semaglutide linked to lower predicted dementia risk

#149

Post by paulpauper »

londons_explore wrote: post #23

So has anyone managed to separate the effects of semaglutide from the effects of weight loss? If this is caused by the weight loss, it is a little disappointing that public health didn't act quicker - lots of people have been overweight for a century now, so literally 10's of millions of people could have been saved from dementia had action been taken 100 years ago.

it is a little disappointing that public health didn't act quicker - lots of people have been overweight for a century now, so literally 10's of millions of people could have been saved from dementia had action been taken 100 years ago

Given that the drug did not exist until only recently and it took decades to develop with the latest of technology, I don't see how this could have been possible. Stomach surgery has been around for 50 years though, but it's a bigger undertaking than an injectable drug.

Re: Semaglutide linked to lower predicted dementia risk

#150

Post by object-a »

wackget wrote: post #120
object-a wrote: post #106

Earlier quoted context omitted.

What is junk food? For example — are cheeseburgers and French fries junk food? What about when you make them at home, or at a fancy restaurant without artificial ingredients? Is it certain additives? If McDonalds makes a happy meal without additives, is it no longer junk food? What does treat them like cigarettes mean? Tax them? Ban them within 15 feet of a building entrance? Put warning labels? Is giving or selling…

Most of the time when people try to define healthy food vs. junk food in a fair and unbiased way, the line gets drawn at "whole foods" vs "processed foods". A typical burger meal is definitely processed food because the meat is processed mechanically and mixed from different sources (usually with added fat); the bun is made from refined flour and refined oils; and the fries are thinly-cut potatoes blanched and fried…

Why does grinding the meat at home make a huge difference vs grinding it in a factory? Depending on the cut you choose, the condiments you add, and the portion size, a hamburger at home could be Lot less healthy than a McDonald’s burger. McDonald’s patties don’t have any fillers afaict.

The point is that “junk food” is a pretty amorphous and vague category. If you want to enforce portion or calorie restrictions you can do that, but it would have to be way more encompassing of a regulation than targeting “junk food”

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