Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Improvement in advanced Alzheimer’s disease following high-dose psilocybin

frontiersin.org

Post reply on HN
Print view View original

141–150 of 166 posts

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#141

Post by globalise83 »

agumonkey wrote: post #98
sowbug wrote: post #66

I was recently reading about a phenomenon called terminal lucidity, where a person suffering from mental decline such as Alzheimer's spontaneously improves, recognizing loved ones, retrieving memories, and being able to carry on conversations. It's called "terminal" because the person usually dies within hours or days. If this is a real phenomenon, then it's amazing to think that at least some of the people who suffe…

Same thing happens for other disease. Some kind of last honey moon period where your health improves and often followed by a catastrophic relapse. I'm nobody but it makes me feels there's an economic system issue, the body gradually degrades but has the ability one last time to inject a final wave of change to try restore a proper state but the resources are too short and so the attempt cannot sustain itself. I wonde…

Well documented in Acute Radiation Syndrome, and features in the excellent show Chernobyl.

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#142

Post by eigencoder »

new-treatment wrote: post #87
trumpdong wrote: post #16

Psilocybin is one of those things we don't even know the full effects of because the government had a hysterical fit and completely banned it because people who took it were more likely to oppose the Vietnam War.

>>the government had a hysterical fit and completely banned it because people who took it were more likely to oppose the Vietnam War. If you are to believe the Brave New World ( https://en.wikipedia.org/wiki/Brave_New_World ) worldview of Huxley (who topically was on loads of LSD himself), you'd think the government would want to flood the public with psychedelics -- low to zero toxicity, allows people to zone out, n…

I thought the Soma in BNW was more like a type of depressant, like an opioid.

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#143

Post by markdown »

shepardrtc wrote: post #90
whimsicalism wrote: post #69

Earlier quoted context omitted.

i’m skeptical how much of a real thing this is vs particularly type of appealing story to the human psyche

It happened to my father, who was suffering a severe mental decline because of hydrocephalus. After weeks of trying to figure out what happened, one day he was sitting in the hospital perfectly fine, talking normally. I remember being so relieved. But then the next day he was back to not knowing anything and being half aware. He died a few weeks later.

I'm sorry but it didn't happen to him.

The phenomenon being discussed here is terminal lucidity. Hours or a day or two before passing.

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#144

Post by embedding-shape »

malfist wrote: post #137
tasty_freeze wrote: post #130

How is this ethical? The ethics section of the summary simply asserts it was OK, but I don't see how this being done in a private practice excuses them from normal strictures. They say this wasn't an experimental protocol, nor research, so I guess they dosed grandma for shits and giggles? Ethics statement Ethical approval was not required for this single case report conducted in routine private clinical practice, in…

> Written informed consent was obtained from the patient’s legal guardian They didn't even get consent from the person being drugged. That is absolutely insane.

They did, legal guardians, for all intents and purposes, "are the person", otherwise the concept in itself wouldn't really work.

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#146

Post by ChoGGi »

WhyNotHugo wrote: post #111
UnfitFootprint wrote: post #3

Good riddance - this kind of thing needs to be experimented with more. But 5 grams! This reads like witch doctor science; I’m surprised it passed ethics

5 grams isn't a high dose though, I'm not sure why it's described as such. Shops sell doses starting at 15g, although they recommend newbies take only half of that. Example of a shop which describes 5g as a "light dose": https://www.sirius.nl/atlantis/

5 grams is what most people especially those new to mushrooms would call an intense experience.

.5 grams to 1.5 grams is a mild experience.

For a personal example; I accidently did 9 grams of golden teacher, tripped balls, and woke up in the hospital with bruises and a cracked rib. It was not an enjoyable experience.

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#148

Post by 40four »

Marciplan wrote: post #122
40four wrote: post #9

This exact case study came up on a recent Rogan episode with Dean Radin, PhD. While the result is very interesting and perhaps illuminating about the unexpected biological mechanisms, apparently the effects were very short lived. Even more interesting, Dr. Radin discussed one of his companies is working on a new drug that uses the same brain receptors as psilocybin, that has the potential to induce similar effects (w…

please go find better resources over Rogan come on

I think the Rogan hate has gone too far. I don’t really get it. I’m mean I do, I just disagree. It’s just entertainment. I learned about an interesting person I’d never heard of before, and had fun listening a conversation about unusual topics I’d likely have never found anywhere else. Now I can read that guys books and look more into what he’s doing because I’m curious and find what he’s doing fascinating. It’s really nothing more than that

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#149

Post by Pxtl »

the_doctah wrote: post #73
Pxtl wrote: post #54

Earlier quoted context omitted.

Yup. Not sure which particular stopped-clock struck right within the generally anti-science MAHA movement but I think everybody is happy to take the win.

[flagged]

Do persons not birth?

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#150

Post by tonyarkles »

_whiteCaps_ wrote: post #93
asveikau wrote: post #58

Earlier quoted context omitted.

Ironically enough, the psychedelic field sort of defies some scientific analysis, so could be construed as "anti-science". I've seen some commentary that it's difficult to test. As an example, you can't really do a double blind study with a placebo because it's obvious to everybody who got the drug.

Niacin works well as an 'active placebo'.

I’ve seen studies use methylphenidate as well for the “control” group. Relatively harmless, will have some effects and side effects on naive subjects.
Post reply on HN