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Sleep research led to a new sleep apnea drug

temertymedicine.utoronto.ca

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Re: Sleep research led to a new sleep apnea drug

#141

Post by justinator »

UberFly wrote: post #76
justinator wrote: post #47

Earlier quoted context omitted.

> what I believe in many cases is a structural issue Many cases it is not. I'm not trying to be a contrarian but I don't want to plant hope in some people who suffer from sleep apnea thinking it's something they can just do breathing exercises for. https://www.mayoclinic.org/diseases-conditions/central-sleep...

In MOST cases it actually is a structural issue. The brain anomaly that causes paused and intermittent breathing is much more rare.

Maybe? I didn't write "most", I wrote "many". What do you have a problem with syaing "many" instead of "all"

I suffer from obstructive sleep apnea, but I would never, ever tell people that their sleep apnea HAS to be obstructive too.

It's like telling a Type 1 Diabetic that they had a friend with diabetes that "cured" themselves with diet. We're talking about two different problems, and we don't discount the Type 1 Diabetic because there are Type 2 Diabetics.

Re: Sleep research led to a new sleep apnea drug

#142

Post by justinator »

ajkjk wrote: post #135
JoeyJoJoJr wrote: post #79

Earlier quoted context omitted.

I don’t think it’s an outlandish take at all. You can possibly also put orthotics and spectacles in the list of interventions as solutions to problems largely induced by unnatural adaptations to an unnatural environment.

yeah... mostly I said it that way because this take upsets some people. The full list (which I think are 80+% fixable by lifestyle) is something like: sleep apnea, obesity, back pain, most things that require physical therapy outside of injuries, probably orthotics and myopia, depression, ADHD, anxiety... probably there are others I'm not thinking of also. I would like to also include cancers since we cause most of t…

Which physical therapies are "interventions as solutions to problems largely induced by unnatural adaptations to an unnatural environment"?

As a math and physics expert, you also claim to be proficient at body movement. Go off king, I'll wait. And AHDH huh? Cancer, uhuh. You're a pyschoholigist and doctor too.

Keep going Dunning-Kruger.

F'n hell yn.

Re: Sleep research led to a new sleep apnea drug

#143

Post by an0malous »

justinator wrote: post #47
an0malous wrote: post #29

I went through the whole process of seeing an ENT, using the machine for the at-home sleep study so insurance would give me a CPAP, then not being able to sleep with a CPAP, and over the course of a couple years I fixed my sleep apnea by fixing my posture and breathing. If you have forward head posture or are not used to breathing through your nose, you might also benefit from this. I think it’s kind of crazy that we…

> what I believe in many cases is a structural issue Many cases it is not. I'm not trying to be a contrarian but I don't want to plant hope in some people who suffer from sleep apnea thinking it's something they can just do breathing exercises for. https://www.mayoclinic.org/diseases-conditions/central-sleep...

Sure, and I wouldn’t tell someone to not see an ENT, and maybe a CPAP, surgery, or this pill are the right solution for you. I’m just throwing out another option to consider with different tradeoffs.

Re: Sleep research led to a new sleep apnea drug

#144

Post by kotaKat »

antisthenes wrote: post #114
Shadowmist wrote: post #58

Earlier quoted context omitted.

Better to outright buy the machine online, then open it up and disable the modem.

Why in the world does a CPAP machine need a modem?

Many patients starting out CPAP therapy go noncompliant because they have various issues or concerns with the machine, mask comfort, etc.

Insurance companies are tired of paying thousands of dollars in machines and supplies that don't go used, so they instead 'rent' the machines from medical equipment suppliers, and use the machine's usage data to determine that you are still using it (and thus continue to pay for treatment). Typically after a year or so of usage they get 'paid for' but there's still ongoing compliance monitoring to get insurance to pay for supplies.

The sleep lab and sleep doctors can also remotely review the usage and make adjustments as needed. One example is using the humidity sensors in ResMed units to adjust the humidification settings remotely. I was with a doctor that showed usage logs together and noted the bedroom was severely dry and thus we needed to adjust the humidifier to run hotter to compensate.

Re: Sleep research led to a new sleep apnea drug

#145

Post by an0malous »

deepspace wrote: post #72
procone wrote: post #49

Earlier quoted context omitted.

What a ridiculous post. Please leave the Reddit pseudoscience at the door. There are researchers actively working and studying people with sleep apnea. They're not suffering from "forward head posture" or "breathing wrong". I have severe sleep apnea and no amount of "breathing exercises" are going to cause my soft palate to uncollapse itself while I'm trying to get REM sleep.

Yes! It is a shame that this kind of nonsense gets upvoted. Pure snake oil.

I’m not selling anything, you can learn any of these exercises online for free and there’s no risk. The guy in the article is the one trying to make billions of dollars selling you a pill that alters your brain chemistry and you’ll need to buy monthly for the rest of your life.

Re: Sleep research led to a new sleep apnea drug

#146

Post by toast0 »

petesergeant wrote: post #109
toast0 wrote: post #87

Earlier quoted context omitted.

Also worth a try... B1 (thiamine) seems to help for me. I don't have objective numbers, but I disturb my spouse with my snoring and breathing troubles far less. I believe I have (undiagnosed) central sleep apnea rathee than OSA though, it's been a long time since I had a sleep study, but I had only one event over a few recorded nights... But some nights it's pretty bad.

Thanks, ordered some, will give it a shot

Awesome, I hope it's helpful for you!

My experience is that it has a noticable effect about 30 minutes after ingesting. I'm currently taking 100 mg tablets. I had done a liquid suspension, but tablets are easier and more consistent.

If you don't notice a difference in the first few nights, it probably doesn't work for you, but b1 seems pretty inexpensive to try.

It doesn't seem to be like some things where you have to use it for two weeks before you notice a difference; but also there's not much (if any?) residual effect. Maybe I can forget to take it one night, but on the second morning, my spouse will ask me if I've been taking my B1. But, sometimes I do have episodes when I have been consistent, so not a silver bullet.

Re: Sleep research led to a new sleep apnea drug

#147

Post by 4gotunameagain »

connicpu wrote: post #122
chasebank wrote: post #53

Earlier quoted context omitted.

Have you tried losing weight and if so, did that help?

The fatigue from sleep apnea makes it more difficult to have productive workouts.

It is well known that weight loss has more to do with caloric intake management than workout intensity

Re: Sleep research led to a new sleep apnea drug

#148

Post by luxuryballs »

tickerticker wrote: post #133
luxuryballs wrote: post #44

I always thought as a stomach sleeper why not get one of those massage table head rest things, face down symmetrical and wouldn’t gravity help keep things open then? Just have to build it into a cozy bed, not sure if that would be comfortable though.

I also thought of this idea and wanted to try it. Gemini said not to do it bc when we sleep, we naturally want to change positions. Thus, maintaining one position all night would cause muscle cramps?

yeah true, maybe it could be good for a power nap “table” if we can make it comfy enough, I did see a massage table head/face cushion adapter that hooks into a normal bed so might be inexpensive to try it out

Re: Sleep research led to a new sleep apnea drug

#149

Post by ajkjk »

justinator wrote: post #142
ajkjk wrote: post #135

Earlier quoted context omitted.

yeah... mostly I said it that way because this take upsets some people. The full list (which I think are 80+% fixable by lifestyle) is something like: sleep apnea, obesity, back pain, most things that require physical therapy outside of injuries, probably orthotics and myopia, depression, ADHD, anxiety... probably there are others I'm not thinking of also. I would like to also include cancers since we cause most of t…

Which physical therapies are "interventions as solutions to problems largely induced by unnatural adaptations to an unnatural environment"? As a math and physics expert, you also claim to be proficient at body movement. Go off king, I'll wait. And AHDH huh? Cancer, uhuh. You're a pyschoholigist and doctor too. Keep going Dunning-Kruger. F'n hell yn.

huh? I said nothing of the sort. They're hunches.

Like: for example, it seems fairly obvious that some societal-level change happened around the 70s or 80s that triggered our modern obesity epidemics. My personal best guess is that it was the rise of processed foods messing up people's gut bacteria, but I have no actual idea. Nonetheless: you can spend as much time and energy (as a society) as you want curing obesity, but if ultimately the cause is in our food quality, then the "right" fix is obviously to fix that. The same claim applies to skin cancer and dietary connections: if the Mediterranean diet or general food quality is responsible for lower incidence of cancers in those places, then ... food quality should be fixed, right? (and sun exposure, of course, is another variable that you can just do things about).

You don't have to be an expert to think that has some validity. It's obvious. I am just quoting the expert theories, anyway.

The point really is: interventions like 'change the quality of food in America' are not things doctors can, like, prescribe to people. But they are things we can aspire to do. They will just take social movements instead of medical treatments to pull off.

Re: Sleep research led to a new sleep apnea drug

#150

Post by array_key_first »

jfengel wrote: post #43
an0malous wrote: post #29

I went through the whole process of seeing an ENT, using the machine for the at-home sleep study so insurance would give me a CPAP, then not being able to sleep with a CPAP, and over the course of a couple years I fixed my sleep apnea by fixing my posture and breathing. If you have forward head posture or are not used to breathing through your nose, you might also benefit from this. I think it’s kind of crazy that we…

Nestor's book didn't feel right. I don't think he's a crank, or that he's entirely wrong, but the idea that we're breathing wrong feels really unlikely. You don't have to be taught to breathe. I'm sure that many of the lessons in the book are applicable and there is much to learn. But a lot of it felt like woo, even though I know full well that the author is a well-respected journalist. I'd really like to hear a soun…

You can generally see who has sleep apnea just by looking at their face - there's a particular anatomy that comes with heavy mouth breathing and obstructive sleep apnea. If you speak to people who have obstructive sleep apnea, virtually all of them report mouth breathing and mouth dryness.

I think, probably, there's some structural elements that can make mouth breathing more attractive or easier. But, mouth breathing doesn't actually work well for the breathing part. So, for those people, they experience obstructive sleep apnea. For others, they don't. I have spoken to sprinters who have told me that even sprinting is easier to do with nose breathing. But, for others, they cannot even sleep while nose breathing.

So, I definitely believe there are structural elements at play with breathing.

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