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Enhancing gut-brain communication reversed cognitive decline in aging mice

med.stanford.edu

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Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#141

Post by adaptbrian »

meindnoch wrote: post #131
adaptbrian wrote: post #99

Earlier quoted context omitted.

It certainly anecdotal, but feels like you can positively effect your gut microbiome for example by riding a horse. Ive read research about how other mammals can share their microbiomes with humans, if its not the horses biome then what is it that so satisfingly calming post ride. Would love to be enlightened. Ride a horse if you need to destress, amazing creatures.

It certainly anecdotal, but feels like you can positively effect your gut microbiome for example by riding a bicycle. If its not the bike's biome then what is it that so satisfingly calming post ride. Would love to be enlightened. Ride a bike if you need to destress, amazing machines.

https://www.frontiersin.org/journals/cellular-and-infection-... https://www.cell.com/iscience/fulltext/S2589-0042(25)02209-6 https://www.sciencedirect.com/science/article/pii/S235277142...

im talking about impacting your microbiome through another animal, not the short term effects from aerobic exercise or BDNF and what that feels like. this experience didnt hit quite like other typical metabolic functions.

great to hear you like BDNF. we all could use more of that.

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#142

Post by mhluongo »

meindnoch wrote: post #128
zinkem wrote: post #28

Earlier quoted context omitted.

I believe this research is totally true-- I had a lot of memories come back after 1. I stopped drinking heavily and using other drugs, i.e. marijuana 2. managed my diet to avoid heartburn without medication 3. schedule my meals so it was easier to sleep at night (always eat something for breakfast when I wake up) I did not need any "poo infusion" or anything. I had a gal bladder removal that didn't fix the problems t…

So, you stopped being an alcoholic and pothead, and your memory improved? Wow, it must be those gut microbes!

What unnecessary snark. Is a little civility too much to ask for?

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#143

Post by iammjm »

I believe there is a lot of shame-induced ignorance around this whole subject. Culturally poopin' is in the similar category like sex or death, outlawed from most "civilized" debates. But consider how central digestion is to our existence: basically almost before everything else we must consume -> digest -> expel first. You are not getting that smart brain of yours without that poopy butthole to go along with it

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#144

Post by uxhacker »

Aurornis wrote: post #62
zinkem wrote: post #28

Earlier quoted context omitted.

I believe this research is totally true-- I had a lot of memories come back after 1. I stopped drinking heavily and using other drugs, i.e. marijuana 2. managed my diet to avoid heartburn without medication 3. schedule my meals so it was easier to sleep at night (always eat something for breakfast when I wake up) I did not need any "poo infusion" or anything. I had a gal bladder removal that didn't fix the problems t…

> 1. I stopped drinking heavily and using other drugs, i.e. marijuana Heavy alcohol use and marijuana are both known to impact memory and recall directly. Discontinuing both of those explains changes in memory. Attributing this to microbiome changes does not follow.

This paper actually surveys research on humans and not mice.

The association between gut microbiota and cognitive decline: A systematic review of the literature

https://www.sciencedirect.com/science/article/pii/S027153172...

It shows ”Gut microbiota modulation improves cognition in adults with early impairment. Diet, probiotics, and fecal microbiota transplantation share mechanistic pathways and that evidence clarifies how microbiota-targeted strategies support cognitive health.”

The action could be explained due to an anti inflammatory action by the gut biome.

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#145

Post by FrustratedMonky »

Article doesn't mention any particular foods that would help.

Is it the typical, eat more fiber, more non-processed, Mediterranean? And this is just showing yet another thing that diet impacts? A link exists, but no specific types of diet to help with aging?.

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#146

Post by hattmall »

wafflemaker wrote: post #112
zinkem wrote: post #28

Earlier quoted context omitted.

I believe this research is totally true-- I had a lot of memories come back after 1. I stopped drinking heavily and using other drugs, i.e. marijuana 2. managed my diet to avoid heartburn without medication 3. schedule my meals so it was easier to sleep at night (always eat something for breakfast when I wake up) I did not need any "poo infusion" or anything. I had a gal bladder removal that didn't fix the problems t…

The really crazy thing that happened to me when I changed diet to a more gut-biome friendly* is that (like I craved sweets before) I started craving vegetables and oatmeal. Like there was a regime change in my gut and the new guys pushed the buttons to get more of their food. (less/no simple sugars, much more vegetables and starches/fibers, regularly eating 4 corn/20 plant oatmeal few times a week)

> 4 corn/20 plant oatmeal

What does this mean?

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#147

Post by DaedalusII »

Mistletoe wrote: post #50
theshrike79 wrote: post #44

"You" don't crave stuff, the microbiome in your intestine craves stuff. There are microbes in there that specialize in eating, say, sugar. You don't give them sugar, they send signals to your brain saying "yo, more sugar" This is why if you go on a sugar-free diet (just stop eating candy and sweets) the cravings just go away eventually. The microbes who keep shouting for more sugar either die away or go dormant.

You’ve heard of The Selfish Gene theory from Richard Dawkins but I’ve started talking about The Sefish Tube. If you think about us another way, we are a tube of GI tract that does everything in its life and with its power to simply be full.

Heraclitus — 'For the best men choose one thing above all—immortal glory among mortals; but the masses stuff themselves like cattle.'

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#148

Post by iammjm »

Aurornis wrote: post #72
theshrike79 wrote: post #44

"You" don't crave stuff, the microbiome in your intestine craves stuff. There are microbes in there that specialize in eating, say, sugar. You don't give them sugar, they send signals to your brain saying "yo, more sugar" This is why if you go on a sugar-free diet (just stop eating candy and sweets) the cravings just go away eventually. The microbes who keep shouting for more sugar either die away or go dormant.

If this was true, sugar cravings would disappear when taking antibiotics that kill those microbes. The fact that this doesn’t happen should give you pause about this woo-woo theory of cravings. The reason you crave sugar and fat and other tasty things is that they taste good. You evolved in a world where feeling rewarded and driven to consume more of these was beneficial to survival when food was scarce.

Clearly "tasting good" is not the primary driver behind all of this. Good taste is an incentive to satisfy something more primary, similar like sex feels good in order to satisfy procreation

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#149

Post by hattmall »

virtue3 wrote: post #97
WarmWash wrote: post #91

Earlier quoted context omitted.

I stopped taking esomeprazole after being on it for 4 years, and frequently had to supplement with famotidine and tums anyway. I had an infection and was prescribed antibiotics, and needed to pause the esomeprazole. I asked gemini about it and it suggested I take two probiotics while on the antibiotics, Saccharomyces boulardii and Lactobacillus rhamnosus GG. I noticed after a few days that I wasn't getting heartburn,…

thank you going to try this. I noticed my heartburn got a lot worse after having to take a few courses of antibiotics.

Some good notes on heartburn, a fiber regime, some combination of wheat dextrin, psyllium husk, inulin. All 3 are different and serve a somewhat different function.

Foods to eat, oatmeal, lentils.

Ginger tea, activated charcoal tabs.

Most all of that works very well to support gut bacteria so throwing some probiotics in as well can help. The gummy kind available in generic or Digestive Advantage work well!

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#150

Post by papyrus9244 »

meindnoch wrote: post #134
papyrus9244 wrote: post #130

Earlier quoted context omitted.

> you should not eat it all day How sure are we about this? How certain are we that those specific species of mold have a net negative effect, rather than a net positive (like for example mushrooms)? Penicillium grows on stale foods and I doubt eating it would have a net negative effect.

>I doubt eating it would have a net negative effect. Feel free to eat it. "Penicillium Species and Their Associated Mycotoxins" - https://pubmed.ncbi.nlm.nih.gov/27924532/

Muchrooms have mycotoxins too. And red meat is a carcinogen. And predator fish have plenty of heavy metals. And the list goes on and on. Yet we eat all those things. Hence the "net positive".
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