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USA, what my wife’s OB told her. 20 years ago.
Oh I was hoping for a written down reference from an organisation responsible for giving medical advice rather than an single doctor.
https://health.clevelandclinic.org/pregnancy-safe-medication...
While they do list some medicines, note that they also say check with your doctor first.
Expected in-depth discussions about the topic, but got pseudo-science medical advice instead. I guess HN _is_ a 'social media' after all.
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If I ever had to say anything about Paracetamol, it would be: Remember: Paracetamol is hepatotoxic, very strong for your liver. Never take it if you have been drinking alcohol or have a weak/damaged liver. Paracetamol is the worst thing you can have for hungover: it might reduce your headache but will hurt a liver that it's already under pressure by the alcohol you drank last night. In moderation, as prescribed, shou…
Side note, here's a Scrubs clip from 2001 that shows just how ubiquitous Tylenol was.
https://www.youtube.com/watch?v=EcDWj7kZcRc
I know the anti-vax crowd is full of homeopaths, chiropractors, and tarot readers. But they're not wrong about one thing: drug companies make money by selling drugs. If we can't guarantee real oversight before those drugs hit the market, we're in deep trouble.
I won't take acetaminophen (usually) learning of the liver toxicity and low overdose potential. And I have a friend that destroyed his kidneys with ibuprofen and is on a transplant list. But from what I understand acetaminophen also dulls emotional pain like from being fired or breaking up with a girlfriend which is interesting. I still prefer to take neither if I can avoid it and I'll hurt a little bit instead. Hurt…
> And I have a friend that destroyed his kidneys with ibuprofen Acetaminophen is not ibuprofen. But I also don't like planes because a friend of mine died in a car crash.
There is also the final sentence about preferring to take "neither". Which of course indicates _two_ substances.
But just to be safe, I don't think the liver and the kidneys are the same organ either :)
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Yes, https://www.thisamericanlife.org/505/use-only-as-directed The episode shows how even small overdoses of acetaminophen can cause fatal liver damage, while decades of FDA delays and confusing drug labeling left millions of Americans at risk.
Tylenol is very safe if taken as prescribed. The overdose amount is relatively low, but not uniquely low. The alternatives are worse - ibuprofen destroys your stomach lining if taken at the regular dose for too long.
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I always reach for aspirin for mild pain and people have this weird idea that its way more dangerous than paracetamol because its a blood thinner and "what if you bleed for some reason and it doesnt stop" - How is that worse than guaranteed liver damage if you take paracetamol? It almost seems like there was this big push to get people away from Aspirin to tylenol and thats why people have that idea stuck in their he…
An aspirin here or there is probably fine but multiple day dosing of full dose aspirin for chronic pain has gotten a lot of middle age people to bleed out their GI tract and end up dead.
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Yes, https://www.thisamericanlife.org/505/use-only-as-directed The episode shows how even small overdoses of acetaminophen can cause fatal liver damage, while decades of FDA delays and confusing drug labeling left millions of Americans at risk.
Tylenol is very safe if taken as prescribed. The overdose amount is relatively low, but not uniquely low. The alternatives are worse - ibuprofen destroys your stomach lining if taken at the regular dose for too long.
The issue is that the overdose of Paracetamol is relatively similar to the effective, or safe, dose:
"(overdose) of paracetamol is caused by taking more than the recommended maximum daily dose of paracetamol for healthy adults (three or four grams),[38] and can cause potentially fatal liver damage. A single dose should not exceed 1000 mg ..." [1]
See the problem ? A mere 3x the single dose puts one in "potentially fatal liver damage" territory.
This problem is compounded dramatically in small children where errors in the estimation of the child's weight can put you half way to overdose before you even start. Now add a meniscus error as you fill a clear plastic cup in the middle of the night ... or Mom gives a dose at 5am without knowing that Dad already gave a dose at 2am ... ugh.
Compare this to Aspirin where the overdose is as high as 15-30x the effective dose.
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Sure but it’s pretty easy overdose on paracetamol. Since it’s a mild and really common painkiller, sometimes seen as not dangerous, someone uneducated about it who is really suffering could easily take 3 or 4 times the dose. Unlike a lot of drugs, you are not going to have a lot of immediate side effects if you overdose on paracetamol. You’ll just horribly die some days after,
How can you reach adulthood and think it's ok to take 3 or 4x the specific dose of any medication? If you're in that much pain you go to a doctor. Which makes me think maybe the issue is the private health system and not the drug.
She would take a dose for a headache, ten minutes later she'd forgotten so she'd take another dose, ten minutes later, she had forgotten, take another dose, rinse and repeat until it's time for a trip to the hospital.
Maybe it wasn't ten minutes between, probably fewer given how much she'd ended up taking. This happened thirty or so years ago.
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Unsure if this is related, but I’ve heard that taking painkillers for delayed onset muscle soreness will reduce muscle gains.
Painkillers like ibuprofen are NSAIDs which inhibit the enzyme COX1/2, reducing prostaglandin production. Prostaglandins are an inflammatory hormone that do a variety of things, but specifically PGE2 plays a role in muscle stem cell activation to divide and produce more muscle fibers. The effect is probably realistically small, but you will leave gains on the table by taking ibuprofen after hard workouts.