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Ozempic shows anti-aging effects in trial

trial.medpath.com

141–150 of 868 posts

Re: Ozempic shows anti-aging effects in trial

#141

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

Naturally skinny people hate Ozempic for the same reason I know many talented engineers who hate AI coding.

Thank you for your service

Re: Ozempic shows anti-aging effects in trial

#142
post #54

Earlier quoted context omitted.

I was kind of scared of these when Ozempic starting picking of steam for weight loss. I was worried that this would be having more negative effects. Turns out, generally speaking, if used with you doctor, these things are pretty safe, especially comparatively to some of the negatives of being overweight. And then I saw some of the stories on HN about how it's changed peoples lives for the better. And then people in m…

It's great because we had no other way to address this problem at a population level. Not any realistic ones, anyway. Like, I figured we were just never going to solve it, given the two possibilities were "radically re-engineer US culture such that moving to the US doesn't make previously-skinny people fatter" (with other countries heading the same direction as us needing to make similar moves, one supposes) or "find…

I helped my dad lose 50 lbs by finally, after 10 years, getting him to give up bread, sugar, potatoes. It took buying him 2 months of a bluetooth glucose monitor. Once he saw what certain foods do, he believed me finally. At 65 years old, healthier than I remember since he was 40 and I was a teen. It doesn't require some weird injection.

Re: Ozempic shows anti-aging effects in trial

#143

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

I'm not a fan because it's expensive and once you go off of the drug the weight comes back on (at least from what I've read). That's not a trade-off I want to take lightly. There's also something to be said for gaining the discipline to do it yourself along the way, which may lead to keeping more of the weight off in the long run. We also don't know what the long term side effects of it will be, if any. I don't find…

[deleted]

Re: Ozempic shows anti-aging effects in trial

#144
In a recent podcast[0], Ben Bikman explained some of background and pitfalls of GLP-1 drugs. When the drugs were first prescribed, dosages were much smaller than the dosages now prescribed for weight loss. Microdosing might be a better and safer strategy.

The podcast is only 3 hours long! The GLP-1 discussion starts at 2:09:53.

[0] https://www.foundmyfitness.com/episodes/ben-bikman

EDIT: ycopilotFYT version https://www.cofyt.app/search/dr-ben-bikman-how-to-reverse-in...

Re: Ozempic shows anti-aging effects in trial

#145
post #83

Earlier quoted context omitted.

I tried it. I started down about 80 lbs from my heaviest, but a good 40 lbs from ideal/20 lb from healthy weight. The first time I tried it I followed dosing guidelines for ramp up; side effects were horrible, didn’t lose much weight, and it just kept getting worse. Second time, after a few months off, I started at lowest dose and stayed there. Side effects were better to start but ramped up again. Eventually my dige…

Try Zepbound. You lose more weight with far fewer side effects. Although, you may still have issues. It does just sound like there's something unique about your chemistry. I don't think that many of those side effects are even in the ballpark of normal.

I would like to try it, but I don’t think it is available from shady internet doctors and insurance won’t cover it because I’m not diabetic. Shady internet ozempic passes the cost-benefit test (barely, considering I can successfully lose weight without it it’s just hard). Full cost out of pocket it does not. Maybe in a few years.

I would worry that the side effects I care about are not the side effects that others report being improved on zepbound.

Re: Ozempic shows anti-aging effects in trial

#146

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. (From that perspective:)a miracle cure that allows someone to stop being fat is like an indulgence (in the Roman Catholic sense). It’s a cheat, a shortcut that allows the unworthy to reach a state they do not deserve. My opinion is to wait long enough to validate there are no lon…

You can be gluttonous and still thin. I eat 2 lbs of ground beef a day, with tons of cheese on it. For breakfast I have 6-8 eggs, with cheese. I have my morning coffee with heavy whipping cream. For desert, I whip up some of the heaving whipping cream and have it with frozen berries thawed out. It drives gfs nuts but they're too anti fat to try it.

Re: Ozempic shows anti-aging effects in trial

#147
post #57

Earlier quoted context omitted.

And also the idea that it is "easy" to lose weight is completely out of touch. If it was there wouldn't be millions of people trying hard, spending money on trying and failing for decades, and entire businesses addressing that. RFK Jr's "let them eat less" is paradoxically the modern version of "let them eat cake"!

> And also the idea that it is "easy" to lose weight is completely out of touch. If it was there wouldn't be millions of people trying hard, spending money on trying and failing for decades, and entire businesses addressing that. This is a touchy topic, but I would like to point out that you're missing the obvious confirmation bias that comes with this observation. There are many people who modulate their weight by c…

and there are people who don't get fat no matter what they eat. Not sure what difference it makes to the millions of people I am refering to. Not even sure what is your point.

Re: Ozempic shows anti-aging effects in trial

#148
post #47

Earlier quoted context omitted.

Haven’t these types of drugs been in use for ~15 years?

> Haven’t these types of drugs been in use for ~15 years? The predecessor of semaglutide, liraglutide has been sold since 1998. GLP-1 has been studied since the 70s. The first human was injected with GLP-1 agonists in 1993 IIRC.

Further, Ozempic itself is nearly 10 now and some people have been on Exenatide for 20+ years continuously now.

These drugs are not novel, or new and we absolutely know the long term health impact.

Re: Ozempic shows anti-aging effects in trial

#149
post #68

Earlier quoted context omitted.

And not just weight loss, but the people I know on GLP-1's have also significantly cut back on alcohol. I think there are ongoing trials around GLP-1's and general addiction.

I find my compulsion towards videogames is decreased. Not eliminated, but I feel much less compelled to be playing all the time.

I'm curious if this affects smartphone usage. E.g., "compulsive" feed-checking and doom scrolling.

Re: Ozempic shows anti-aging effects in trial

#150
post #145

Earlier quoted context omitted.

Try Zepbound. You lose more weight with far fewer side effects. Although, you may still have issues. It does just sound like there's something unique about your chemistry. I don't think that many of those side effects are even in the ballpark of normal.

I would like to try it, but I don’t think it is available from shady internet doctors and insurance won’t cover it because I’m not diabetic. Shady internet ozempic passes the cost-benefit test (barely, considering I can successfully lose weight without it it’s just hard). Full cost out of pocket it does not. Maybe in a few years. I would worry that the side effects I care about are not the side effects that others re…

Protip: Get an ultrasound on your liver. Almost every obese person has (what used to be called) fatty liver, and that's usually enough to justify the prescription to your insurance company.
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