141–150 of 553 posts
Interesting article, but I do have a nit: > Nike is shifting from "Just Do It" impulse messaging to long-term wellness partnerships My read of "just do it" is actually the opposite. It's a message to dedicated athletes about not making excuses end executing.
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What does this even mean? The results of GLP-1 meds are well studied and widely understood to be game changing and likely revolutionary. The other claims might be hyperbolic but results of the medication on individuals is not really a question at this point.
The short term results are known, but we have very little data about the long term effects as of yet.
Is there a term for this style of writing? It's like a longform linkedin post. I don't mean this as a criticism, it just seems like written language is evolving to better capture our diminishing attention spans.
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As opposed to the good long term effects of being obese?
As it happens, in the elderly, a BMI at the lower range of "obesity" is better than having higher or lower weight. Of course, with the shortage of geriatricians, most seniors are unlikely to find this out.
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Yes well your PCP / pharmacist should not have prescribed you an appetite suppressant when you have below average body fat %. The effects are very worth it for people weighing them against heart disease and mobility issues. It's not a Faustian bargain, it's all right on the tin. When you stop taking it the effects go away. If you want to be indulgent and it fits your lifestyle you can reversibly make that decision. T…
After using them, I think GLP-1’s will eventually be rebranded as a weight management / weight maintenance drug rather than a weight loss drug in order to appeal to the masses. It’s a very interesting feeling to feel like you’re in full control of what you eat, not influenced by random cravings or hunger. In my case I’m planning to only stay on it another month or 2 to drop 10lbs. I can easily see people cycling on/o…
I recommend that you listen to the most recent Peter Attia podcast, which is a 2+ hour interview with Ralph DeFronzo (diabetes expert) where he goes deep into the effects of GLP-1 agonists on insulin response and other metabolic pathways. I came away with the impression that we're being too casual with how these drugs are being used -- if you're overweight these impacts are probably all for the good, but if you're not, it's more questionable.
I would point out that it isn't unforeseen, given that genz don't drink, go out or do drugs to anywhere near the extent that millennials did at the same age. ( https://www.statista.com/chart/30783/alcohol-consumption-by-... ) I would also gently point out the evidence for tempering alcohol only seems to be evident with people who have high BMI https://www.pulsetoday.co.uk/news/clinical-areas/mental-heal... So yes, it…
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It is a bit of a silly proposition, considering that 40% of Americans are obese, and many of that population cannot afford $800-$2000 prescriptions.
It's not silly at all. In 15-20 years this stuff will be <$100 for weeks of use. For many people $800 dollars is less than the they spend on food in the same time
The current retail cost in Canada is ~$160 USD per syringe for Ozempic.
I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…
> That late night trip to McDonalds will have you feeling like shit the next day I've never had this reaction to fast food before. I only eat mcdonalds every few months and yea it's not the highest quality food, but I don't think there's anything in it to make you sick any more than other burger places have. I imagine you'd have to have restricted fast-food nutrition for quite some time before you feel a difference.…
> I've never had this reaction to fast food before.
I do. Because of it, I eat fastfood when I'm willing to pay that price, ~5x/decade.
> I'd like to see a study comparing people who ate mcs who thought of it like slop vs those who saw it as a treat. I'm curious how much of this is psychosomatic.
The notion that our psychology could be holding us back from fastfood completeness is one that never occurred to me. I like how novel it is.
I suspect his projections on the impacts these drugs will have on crime rates and alcohol consumption are probably also overblown. I could be wrong, but I would think that the sorts of people who seek out prescription drugs for impulse control aren't likely to overlap with people who drive drunk in the first place.
The anecdote about the lost muffin revenue was still quite interesting.
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> That late night trip to McDonalds will have you feeling like shit the next day I've never had this reaction to fast food before. I only eat mcdonalds every few months and yea it's not the highest quality food, but I don't think there's anything in it to make you sick any more than other burger places have. I imagine you'd have to have restricted fast-food nutrition for quite some time before you feel a difference.…
>> That late night trip to Mcs will have you feeling like crap the next day > I've never had this reaction to fast food before. I do. Because of it, I eat fastfood when I'm willing to pay that price, ~5x/decade. > I'd like to see a study comparing people who ate mcs who thought of it like slop vs those who saw it as a treat. I'm curious how much of this is psychosomatic. The notion that our psychology could be holdin…